Santosh K. Katiyar, Ph.D. - University of Alabama at Birmingham

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Type of Skin Cancer/Carcinogenesis: Animal Models • Chemical carcinogenesis: Initiated by exposure to chemical carcinogens like ubiquitous environmental pollutant, benzo(a)pyrene [B(a)P] and/or 7,12- dimethylbenz(a)anthracene (DMBA). Following carcinogen exposure, tumor promoters may be required to speed up the process of carcinogenesis. – Tumor promoters • TPA (12-O-tetradecanoylphorbol-13-acetate) • Mezerein • Benzoylperoxide (BPO) • Photocarcinogenesis: Initiated and/or promoted by ultraviolet (UV) radiation. UV is also a complete carcinogen.
Multi-stage carcinogenesis model showing initiation, promotion and progression stages Sensitive to carcinogen (SENCAR) mouse model for chemical carcinogenesis. SKH-1 hairless mouse model for photocarcinogenesis
Page 1 and 2: September 11, 2006; Botanicals Work
Page 3 and 4: • The skin is one of the largest
Page 5: Causes of Skin Cancer • Following
Page 9 and 10: UV Radiation and Facts • Although
Page 11 and 12: Dietary supplements may have the ab
Page 13 and 14: Topical application of (-)-epigallo
Page 15 and 16: Hypothesis • We hypothesize that
Page 17 and 18: EGCG inhibits UVB-induced tumor mul
Page 19 and 20: EGCG inhibits tumor growth greater
Page 21 and 22: EGCG reduces or repairs UV-induced
Page 23 and 24: UV-induced Sunburn Cells • The fo
Page 25 and 26: EGCG Repairs UVB-induced CPDs in XP
Page 27 and 28: Conclusion • EGCG from green tea
Page 29 and 30: Working Support • Anshu Mittal, P

Santosh K. Katiyar, Ph.D. - University of Alabama at Birmingham

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