Santosh K. Katiyar, Ph.D. - University of Alabama at Birmingham
Santosh K. Katiyar, Ph.D. - University of Alabama at Birmingham
Santosh K. Katiyar, Ph.D. - University of Alabama at Birmingham
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Type <strong>of</strong> Skin Cancer/Carcinogenesis:<br />
Animal Models<br />
• Chemical carcinogenesis: Initi<strong>at</strong>ed by exposure to<br />
chemical carcinogens like ubiquitous environmental<br />
pollutant, benzo(a)pyrene [B(a)P] and/or 7,12-<br />
dimethylbenz(a)anthracene (DMBA). Following<br />
carcinogen exposure, tumor promoters may be<br />
required to speed up the process <strong>of</strong> carcinogenesis.<br />
– Tumor promoters<br />
• TPA (12-O-tetradecanoylphorbol-13-acet<strong>at</strong>e)<br />
• Mezerein<br />
• Benzoylperoxide (BPO)<br />
• <strong>Ph</strong>otocarcinogenesis: Initi<strong>at</strong>ed and/or promoted by<br />
ultraviolet (UV) radi<strong>at</strong>ion. UV is also a complete<br />
carcinogen.
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