Santosh K. Katiyar, Ph.D. - University of Alabama at Birmingham
Santosh K. Katiyar, Ph.D. - University of Alabama at Birmingham
Santosh K. Katiyar, Ph.D. - University of Alabama at Birmingham
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Risk Factors<br />
• Risk factors are well defined for nonmelanoma skin cancer.<br />
Over-exposure to UV Radi<strong>at</strong>ion and fair skin type<br />
susceptible to sunburns are the predominant risk factors.<br />
Increasing frequency <strong>of</strong> exposure, age, and male gender also<br />
contribute to increased risk.<br />
• The incidence <strong>of</strong> skin cancers, especially SCCs, is also<br />
increased among organ transplant recipients. Kidney and<br />
heart transplant recipients showed a 66-fold increased risk<br />
<strong>of</strong> SCC compared with the general popul<strong>at</strong>ion.<br />
• A comprehensive study <strong>of</strong> 5,356 transplant recipients in<br />
Sweden showed a 100-fold increased rel<strong>at</strong>ive risk <strong>of</strong><br />
nonmelanoma skin cancer, almost exclusively in sunexposed<br />
areas. The increased frequency <strong>of</strong> SCC in these<br />
p<strong>at</strong>ients presumably <strong>at</strong>tributable to long-term<br />
immunosuppressive therapy, although non-immune<br />
mechanisms may also play a role.
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