24. Ulusal Biyokimya Kongresi - TÃ¼rk Biyokimya Dergisi

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XXIV. ULUSAL B‹YOK‹MYA KONGRES‹ 25 - 28 Eylül 2012 Dedeman Otel - Konya 24. Ulusal Biyokimya Kongresi, Konya [24 th National Biochemistry Congress, Konya / TURKEY] İÇİNDEKİLER P231 - D VİTAMİNİ KANSERE KARŞI KORUYUCU MUDUR? 1 Hülya ÇIÇEK, 2 Nesli GÜLEKEN, 3 Serdar ÖZTUZCU, 4 Sibel BAYIL OĞUZKAN, 5 Alper SEVINÇ 1 Gaziantep/Tıp, Tıbbi Biyokimya, Gaziantep 2 Gaziantep, Sağlık Bilimleri Enstitüsü, Gaziantep 3 Gaziantep/Tıp, Tıbbi Biyoloji Genetik, Gaziantep 4 Gaziantep/SHMYO, BİYOKİMYA, Gaziantep 5 Gaziantep/Tıp, onkoloji, Gaziantep P231 - IS VITAMIN D PROTECTOR AGAINST CANCER? 1 Hülya ÇIÇEK, 2 Nesli GÜLEKEN, 3 Serdar ÖZTUZCU, 4 Sibel BAYIL OĞUZKAN, 5 Alper SEVINÇ 1 Tıbbi Biyokimya, Gaziantep/Tıp, Gaziantep 2 Sağlık Bilimleri Enstitüsü, Gaziantep, Gaziantep 3 Tıbbi Biyoloji Genetik, Gaziantep/Tıp, Gaziantep 4 Biyokimya, Gaziantep/SHMYO, Gaziantep 5 Onkoloji, Gaziantep, Gaziantep CONTENTS Kanser ciddi morbidite ve mortalite ile seyreden, sürekli yaygınlaşan bir hastalıktır. D vitamini ise, anti kanser ajanı olduğu düşünülen, kemik mineralizasyonunda önemli rol oynayan, immunomodülatör görevinin yanında, nörotransmitter özelliğine de sahip, hormon özelliği olan bir vitamindir. Bu çalışmamıza Gaziantep Üniversitesi Onkoloji Hastanesinde tedavi görmekte olan 63 akciğer kanseri, 57 kolon kanseri, 53 meme kanseri ve 53 pankreas kanseri tanısı konmuş 226 hasta ile kendilerine ve birinci dereceden akrabalarına kanser teşhisi konulmamış 59 kişiden oluşan kontrol grubu katılmıştır. Serum D vitamini, kalsiyum ve fosfor düzeyleri incelenmiş, kanser hastalarının hem kendi aralarında, hem kontrol grubu ile karşılaştırılması sırasında anlamlı birçok sonuca ulaşılmıştır. Sonuç olarak; D vitamininin bazı kanser türlerinde koruyucu bir rolü vardır ancak bunun daha ileri çalışmalarla pekiştirilmesi gerekmektedir. Cancer is a continuously spreading disease associated with serious morbidity and mortality. Vitamin D is thought to have anti-cancer agent, which plays an important role in bone mineralization, the task of modulating the immune system, as well as have the ability to neurotransmitters, hormones feature a vitamin. In this study, 226 patients diagnosed with 63 lung cancer, 57 colon cancer, 53 breast cancer and 53 pancreatic cancer who had been treated at Oncology Hospital of Gaziantep University and 59 subjects in the control group with first-degree relatives and themselves not diagnosed with cancer were included. Serum vitamin D, calcium and phosphorus levels were examined and compared between cancer patients and the control group and significant results are obtained. In conclusion; vitamin D has a protective role in some cancer types but, it must be strengthen with further studies. Turk J Biochem, 2012; 37 (S1) http://www.TurkJBiochem.com
XXIV. ULUSAL B‹YOK‹MYA KONGRES‹ 25 - 28 Eylül 2012 Dedeman Otel - Konya 24. Ulusal Biyokimya Kongresi, Konya [24 th National Biochemistry Congress, Konya / TURKEY] İÇİNDEKİLER P232 - SUBKLİNİK VE KLİNİK HİPOTİROİDİZMLİ HASTALARDA HOMOSİSTEİN, VİTAMİN B12 VE FOLAT DÜZEYLERİ 1 Erkam İLASLAN, 1 Ahmet KAHRAMAN, 2 Serap DEMIR, 1 Tülay KÖKEN 1 Afyon Kocatepe Üniversitesi/ Tıp Fak., Tıbbi Biyokimya A.D., Afyonkarahisar 2 Afyon Kocatepe Üniversitesi/Tıp Fak., İç Hastalıkları A.D., Afyonkarahisar Tiroid hormonları normal büyüme ve iskelet gelişimi için önemli bir role sahiptir. Hipotiroidizmde tiroid hormonlarının eksikliği veya etkisizliği sonucu metabolik yavaşlama görülmektedir. Hipotiroidizm ile, bir kardiovasküler risk faktörü olarak kabul edilen homosistein arasındaki ilişki ilgi çekmiş ve yapılan çalışmalarda farklı sonuçlar alınmıştır. Homosistein, vitamin B12 ve folat metabolizması ise birbiriyle ilişkilidir. Çalışmamızın amacı hem subklinik hem de klinik hipotroidizm ile homosistein, vitamin B12 ve folik asit düzeyleri arasındaki ilişkiyi araştırmaktır. Bu çalışmada ilk defa tanı konulan yetişkin 20 subklinik hipotiroidizm ve 14 klinik hipotiroidizm hastasından alınan kan örnekleri incelendi. Kontrol grubu 17 sağlıklı bireyden oluştu. TSH düzeyleri 4.20 µlU/mL üzerinde olup da serbest T3 (fT3) düzeyleri 1,80 pg/mL ve serbest T4 (fT4) düzeyleri 0,89 ng/dL nin altında olanlar klinik hipotiroidi, fT3 ve fT4 normal olan hastalar ise subklinik hipotiroidi hastası olarak kabul edildi. Sonuç olarak, homosistein, vitamin B12 ve folat düzeylerinde kontrol grubuna göre hem subklinik hem de klinik hipotiroidi grubunda hafif bir düşüklük olmasına rağmen istatistiksel olarak bir fark görülmedi. P232 - LEVELS OF HOMOCYSTEINE, VITAMIN B12 AND FOLIC ACID IN PATIENTS WITH SUBCLINICAL AND CLINICAL HYPOTHYROIDISM 1 Erkam İLASLAN, 1 Ahmet KAHRAMAN, 2 Serap DEMIR, 1 Tülay KÖKEN 1 Medical Biochemistry, Afyon Kocatepe University/ School of Medicine, Afyonkarahisar 2 Internal Medicine, Afyon Kocatepe University/ School of Medicine, Afyonkarahisar Thyroid hormones have an important role on growth and skeletal development. Hypothyroidism is characterized by decreased metabolism resulting from insufficient production or ineffectiveness of thyroid hormones. The relationship between hypothyroidism and homocysteine which is a cardiovascular risk factor attract attention but, various results have been taken in a lot of studies. Homocysteine, vitamin B12 and folate metabolism is interrelated. The aim of our study is to investigate the relationship between both subclinical and clinical hypothyroidism and homocysteine, vitamin B12 and folat levels. In this study, blood samples which were taken from 20 adult patients with clinical hypothyroidism and 14 adult patients with subclinical hypothyroidism who were diagnosed for the first time samples were analyzed. The control group was 17 healthy subjects. If TSH level of patients are higher than 4,20 μlU/mL, but the free T3 (fT3) levels are lower than 1.80 pg/mL and free T4 (fT4) levels are lower than 0.89 ng/dL, they were accepted as the patients with clinical hypothyroidism. If TSH level of patients are higher than 4,20 μlU/mL, but the free T3 (fT3) and free T4 (fT4) levels are normal, they were accepted as the patients with subclinical hypothyroidism. As a result, homocysteine, vitamin B12 and folate levels in both subclinical and clinical hypothyroidism group were not different than the control group statistically, in spite of a slight decrease was noted. CONTENTS Turk J Biochem, 2012; 37 (S1) http://www.TurkJBiochem.com
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24. Ulusal Biyokimya Kongresi - TÃ¼rk Biyokimya Dergisi

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