Strychnos 1990 - 2004 - Crops for the Future
Strychnos 1990 - 2004 - Crops for the Future
Strychnos 1990 - 2004 - Crops for the Future
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Author<br />
Title<br />
Year<br />
Source title<br />
Reference<br />
Dasilva, B. A., A. P. Dearaujo, R. Mukherjee and A. D. Chiappeta<br />
Bisnordihydrotoxiferine and vellosimine from <strong>Strychnos</strong> divaricans root - spasmol<br />
1993<br />
Phyto<strong>the</strong>rapy Research<br />
7(6): 419-424<br />
Abstract<br />
Bisnordihydrotoxiferine and vellosimine, two tertiary indole alkaloids have been isolated from <strong>the</strong><br />
root of <strong>Strychnos</strong> divaricans. Bisnordihydrotoxiferine antagonized in a nonspecific manner, oxytocin<br />
and acetylcholine induced contractions in <strong>the</strong> rat uterus and acetylcholine and histamine responses in<br />
<strong>the</strong> guinea-pig ileum. Bisnordihydrotoxiferine, like verapamil, produced effects on voltage<br />
dependent Ca2+ channels. For example in guinea-pig ileum, bisnordihydrotoxiferine (pD2' 3.92+/-<br />
0.09) and verapamil (pD2' 6.00+/-0.11) inhibited KCl induced contractions. Fur<strong>the</strong>rmore,<br />
bisnordihydrotoxiferine (pD2' 4.37+/-0.02) and verapamil (pD2 6.83+/-0.10) also antagonized CaCl2<br />
induced contractions of K+-depolarized rat uterus. When compared with sodium nitroprusside, an<br />
antagonist of receptor operated Ca2+ channels, bisnordihydrotoxiferine had no effect. However, in<br />
<strong>the</strong> aorta, <strong>the</strong> alkaloid (IC50, 6.10 X 10(-6) M) antagonized <strong>the</strong> intracellular calcium dependent<br />
transient contractions of noradrenaline and it was about four times more potent than procaine (IC50,<br />
2.30 x 10(-5) m), a known inhibitor of <strong>the</strong> release of Ca2+ from intracellular stores.<br />
Bisnordihydrotoxiferine may produce nonspecific spasmolytic actions mainly by inhibiting<br />
intracellular calcium mobilization and to a lesser extent by inhibiting voltage dependent calcium<br />
c h a n n e l s i n s m o o t h m u s c l e s .<br />
Author<br />
Title<br />
Year<br />
Source title<br />
Reference<br />
Diez A; Vila C; Sinibaldi ME; Troin Y; Rubiralta M<br />
Syn<strong>the</strong>tic studies on indole alkaloids .6. Syn<strong>the</strong>sis of tetrahydroakuammicine and<br />
1993<br />
Tetrahedron Letters<br />
34(4): 733-736<br />
Abstract<br />
The syn<strong>the</strong>sis of dihydrocorynan<strong>the</strong>ol (5) and of <strong>the</strong> pentacyclic <strong>Strychnos</strong> alkaloid<br />
tetrahydroakuammicine (4) is reported from 5-ethyl-N-hydroxyethyl-2-(1-phenylsulfonyl-3-indolyl)-<br />
4-piperidineacetates (1) by means of a K(t)OBu/BF3.Et2O intramolecular cyclization.