Strychnos 1990 - 2004 - Crops for the Future

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Author Title Year Source title Reference Abstract Cao, H., Y. Liu and S. d. Jin Determination of strychnine and brucine in Strychnos nux vomica L. and its prepa 2002 Chinese Journal of Pharmaceutical Analysis 22(4): 279-281 - Author Title Year Source title Reference Chan, T. Y. K. Herbal medicine causing likely strychnine poisoning 2002 Human and Experimental Toxicology 21(8): 467-468 Abstract 'Maqianzi' (the dried ripe seed of Strychnos nux-vomica L.) contains 1.0-1.4% each of strychnine and brucine. After processing to reduce its toxicity, 'maqianzi' was used as a herbal remedy for rheumatism, musculoskeletal injuries and limb paralysis. A 42-year old woman with neck pain was prescribed 15 g of 'maqianzi' to be taken in two doses at 7 hours apart, although the recommended dose was 0.3-0.6 g. She was apparently well after drinking the first of two bowls of 'maqianzi' decoction. One hour after she drank the second bowl of herbal decoction, she suddenly developed tonic contractions of all her limb muscles and carpopedal spasm lasting 5 min, difficulty in breathing, chest discomfort and perioral numbness. The second bowl of decoction probably became more concentrated because of evaporation of water during continued boiling and contained a larger amount of 'maqianzi'. On arrival in the hospital 1 hour later, she complained of muscle pain and tiredness. She was found to have hyperventilation and weakness of four limbs, with muscle power of grade 5(-)/5. All her symptoms gradually subsided over the next few hours. This case illustrated that 'maqianzi' can cause strychnine poisoning even after processing, especially when the recommended dose is greatly exceeded. In any patient with 'unexplained' muscle spasms or convulsions, strychnine poisoning should be included in the differential diagnosis and they should be asked about the use of h e r b a l m e d i c i n e s .
Author Title Year Source title Reference Abstract Ergun, Y., S. Patir and G. Okay Synthesis of the azocino[4,3-b]indole core structure for the synthesis of strychnos 2002 Journal of Heterocyclic Chemistry 39(2): 315-318 - Author Title Year Source title Reference Abstract Frederich, M., M. J. Jacquier, P. Thepenier, P. De Mol, M. Tits, G. Philippe, C. D Antiplasmodial activity of alkaloids from various Strychnos species 2002 Journal of Natural Products 65(10): 1381-1386 - Author Title Year Source title Reference Abstract Hokelek, T., S. Patir, Y. Ergun and G. Okay Ethyl 9h-1,2,3,4-tetrahydrocarbazole-3-carboxylate 2002 Acta Crystallographica Section E Structure Reports Online 58(NOV): O1255-O1257 -
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