Strychnos 1990 - 2004 - Crops for the Future

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Author Title Year Source title Reference Caira, M. R. and P. Rasoanaivo Structure of malagashanine, a new alkaloid with chloroquine-potentiating action 1995 Journal of Chemical Crystallography 25(11): 725-729 Abstract The molecular structure of malagashanine (C23H30N2O4), a new alkaloid occurring in Madagascan Strychnos species and showing chloroquine-potentiating action, has been determined by single crystal X-ray diffraction. The crystals, in the form of a 1:1 acetone solvate, are monoclinic, space group P2(1), with a = 10.328(2), b = 10.554(6), c = 11.490(5)Angstrom, beta = 96.67(2)degrees, Z = 2. Refinement based on 3650 reflections measured at 294K yielded R = 0.045. The X-ray analysis shows that the ring system in malagashanine differs from that in alkaloids of the strychnobrasiline type in containing only five- and six-membered rings. Thermal analysis of the solvate indicates that the acetone molecules are firmly held in the crystal and the X-ray analysis reveals that they are trapped in crystal voids. Only van der Waals forces and C-H ... O hydrogen bonds stabilize the c r y s t a l s t r u c t u r e . Author Title Year Source title Reference Corsaro, M. M., I. Giudicianni, R. Lanzetta, C. E. Marciano, P. Monaco and M. P Polysaccharides from seeds of Strychnos species 1995 Phytochemistry 39(6): 1377-1380 Abstract The chemical composition of polysaccharide fractions from Strychnos nux-vomica and S. innocua seeds and comparison with those from S. potatorum seeds are reported. The structural features of the galactomannans from the three Strychnos species are also discussed. Author Title Year Source title Reference Abstract Delaude, C., P. Thepenier, M. J. Jacquier, J. M. Nuzillard, G. Massiot and L. Le Alcaloides de Strychnos angolensis 1995 Bulletin Societe Royale Des Sciences De Liege 64(4/5): 243-246 -
Author Title Year Source title Reference Hattori, M., T. Nakabayashi, Y. A. Lim, H. Miyashiro, M. Kurokawa, K. Shiraki, Inhibitory effects of various ayurvedic and panamanian medicinal-plants on the in 1995 Phytotherapy Research 9(4): 270-276 Abstract Extracts of 40 Ayurvedic medicines and 39 Panamanian medicinal plants were screened for their inhibitory activity on the plaque formation of herpes simplex virus type I (HSV-1) in cultured cells, The extracts of II plant species showed potent inhibitory activity at a concentration of 100 mu g/mL, while those of ten species showed moderate activities, Repeated oral administration of each extract of Rhus acuminata (galls), Saraca indica (bark), Strychnos potatrum (seeds) appreciably suppressed the development of typical skin lesions induced by infection of HSV-1 in BALB/c mice, The extract of S. potatrum prolonged both development of skin lesion and mean survival time. This indicates that S. potatrum is a possible candidate for therapeutic application for HSV-1 infection. Author Title Year Source title Reference Abstract He, Y. and et al. Influence of different processing methods on four alkaloid contents in Strychnos n 1995 China Journal of Chinese Materia Medica 20(2): 84 - Author Title Year Source title Reference Kizil, M. and J. A. Murphy Stereoselective preparation of the abce tetracycle of aspidospermidine and related 1995 Journal of the Chemical Society-Chemical Communications (14): 1409-1410 Abstract Tandem radical cyclisation affords stereoselective access to the ABCE tetracyclic substructure of a s p i d o s p e r m i d i n e a n d r e l a t e d a l k a l o i d s .
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