Strychnos 1990 - 2004 - Crops for the Future

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Author Title Year Source title Reference Abstract Tits M; Brandt V; Wauters JN; Delaude C; Llabres G; Angenot L Glucoindole alkaloids from stem bark of Strychnos mellodora 1996 Planta Medica 62(1): 73 - Author Title Year Source title Reference Tripathi YB; Chaurasia S Studies on the inhibitory effect of Strychnos nux vomica-alcohol extract on iron in 1996 Phytomedicine 3(2): 175-180 Abstract This report investigates the antioxidant property of Strychnos nux vomica Linn. alcohol extract on FeSO4-induced lipid peroxidation in vitro. The results have been compared to those of vitamin E, parabenzoquinone, Tris, mannitol and EDTA. Tris and mannitol, the standard hydroxyl trappers failed to block this process. Interestingly EDTA, a strong metal chelator, significantly blocks the process of lipid peroxidation. S. nux vomica inhibits the lipid peroxidation in the dose dependent manner. The inhibition of lipid peroxidation was reversed by adding high concentration of Fe2+. This suggests the mechanism of action of S. nux vomica through the chelation of Fe++/Fe+++ ion in the system and not by trapping the hydroxyl radicals. This extract significantly maintains the hepatic glutathione content also in the time and dose dependent manner even in the presence of FeSO4, which is not the case with EDTA. It also inhibits the process of lipid peroxidation once induced. Author Title Year Source title Reference Abstract Tripathi YB; Chaurasia S Effect of Strychnos nux vomica alcohol extract on lipid peroxidation in rat liver 1996 International Journal of Pharmacognosy 344): 295-299 -
Author Title Year Source title Reference Wright CW; Phillipson JD; Awe SO; Kirby GC Warhurst DC; QuetinLeclercq J; Antimalarial activity of cryptolepine and some other anhydronium bases 1996 Phytotherapy Research 10(4): 361-363 Abstract Eight naturally occurring anhydronium bases and the synthetic quaternary compound Nbmethylharmalane were tested against Plasmodium falciparum (strain K1) in vitro. Cryptolepine was found to have similar activity to that of chloroquine but alstonine, 5,6-dihydroflavopereirine, matadine, Nb-methylharmalanae, melinonine F, normelinonine F, strychnoxanthine and serpentine were found to have little activity. Cryptolepine, given orally to mice infected with Plasmodium berghei berghei was found to have moderate antimalarial activity; parasitaemia was suppressed by 8 0 % a t 5 0 m g / k g / d a y . Author Title Year Source title Reference Yamada H; Minematsu Y; Nakamura T; Mise M; Fujisaki H; Oguri K Brucine as a potent inducer of cyp2b3, the third member of the cyp2b subfamily p 1996 Biological and Pharmaceutical Bulletin 19(2): 291-293 Abstract We have indicated that strychnine and brucine induce concurrently an unknown p450 (2B-UP) which cross-reacts with anti-CYP2B1 antibody (Fujisaki et al., J. Pharmacol. Exp. Ther., 268, 1024- 1031, 1994). We purified ZB-UP from brucine-treated rats and characterized it in this study. The purification was achieved by solubilization with sodium cholate followed by successive chromatographic steps with omega-aminoctyl-Sepharose 4B, DEAE-Sephacel and hydroxyapatite. The minimum molecular weight of purified 2B-UP was calculated to be 48000 by sodium dodecyl sulfate-gel electrophoresis. This preparation showed no Soret peak in the ultraviolet absorption spectrum indicating absence of heme. The amino terminal sequence of ZB-UP up to the 10th residue was consistent with the deduced amino acid sequence of CYP2B3 cDNA, but did not agree with the sequences of CYP2B1/2. The result strongly suggests that ZB-UP is CYP2B3. Thus, we indicated here that Strychnos alkaloid, brucine, is a potent inducer of the CYP2B3 or the closely related P450.
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