Strychnos 1990 - 2004 - Crops for the Future

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Author Title Year Source title Reference Oliveira, E. J., I. A. Medeiros and R. Mukherjee Hypotensive and spasmolytic effects of normacusine b from Strychnos atlantica ro 1996 Phytomedicine 3(1): 45-49 Abstract Normacusine B, a tertiary indole alkaloid, was isolated in pure form from the root bark of Strychnos atlantica Krukoff & Barneby. In conscious unrestrained rats, normacusine B (1 mg/kg) decreased the mean arterial blood pressure (27.6 +/- 8.4 mmHg, n = 6), followed by a significant increase in heart rate (115.0 +/- 12.7 bpm, n = 6). The alkaloid failed to induce tachycardia directly in isolated perfused rat heart. In isolated rat aortic rings, normacusine B antagonized phenylephrine and serotonin-induced contractions. Schild plot analysis of individual cumulative concentration-response curves was compatible with a competitive type of antagonism against phenylephrine (pA(2) = 7.05 +/- 0.11) and of a non-competitive nature against 5-hydroxytryptamine (apparent pA(2) = 7.02 - 0.08). Normacusine B was found inactive against KCl and PGF(2 alpha) induced contractions. Author Title Year Source title Reference Abstract Passarella, D., S. Sathyanarayana, M. Amat and J. Bosch Studies on the synthesis of Strychnos alkaloids 1996 Natural Product Letters 8(1): 75-82 - Author Title Year Source title Reference Abstract Patir, S., P. Rosenmund and P. H. Goetz A new synthetic route to the tetracyclic framework of strychnos alkaloids via intra 1996 Heterocycles 43(1): 15-22 -
Author Title Year Source title Reference Rasoanaivo, P., C. Galeffi, G. Palazzino and M. Nicoletti Revised structure of malagashanine: A new series of n-b,c(21)-secocuran alkaloid 1996 Gazzetta Chimica Italiana 126(8) 517-519 Abstract The structure of malagashanine previously assigned as a N-b,C(3)-secocuran alkaloid is indeed a new type of N-b,C(21)-secocuran alkaloid. The structure of a minor related alkaloid, 12- h y d r o x y m a l a g a s h a n i n e , i s a l s o r e p o r t e d . Author Title Year Source title Reference Abstract Rasoanaivo, P., S. Ratsimamanga-Urverg and F. Frappier Recent results on the pharmacodynamics of alkaloids from strychnos in madagasc 1996 Cahiers Sante 6(4): 249-253 - Author Title Year Source title Reference Abstract Saxton, J. E. Recent progress in the chemistry of the monoterpenoid indole alkaloids 1996 Natural Product Reports 13(4) 327-363 -
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