Strychnos 1990 - 2004 - Crops for the Future
Strychnos 1990 - 2004 - Crops for the Future
Strychnos 1990 - 2004 - Crops for the Future
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Author<br />
Title<br />
Year<br />
Source title<br />
Reference<br />
Oliveira, E. J., I. A. Medeiros and R. Mukherjee<br />
Hypotensive and spasmolytic effects of normacusine b from <strong>Strychnos</strong> atlantica ro<br />
1996<br />
Phytomedicine<br />
3(1): 45-49<br />
Abstract<br />
Normacusine B, a tertiary indole alkaloid, was isolated in pure <strong>for</strong>m from <strong>the</strong> root bark of <strong>Strychnos</strong><br />
atlantica Krukoff & Barneby. In conscious unrestrained rats, normacusine B (1 mg/kg) decreased <strong>the</strong><br />
mean arterial blood pressure (27.6 +/- 8.4 mmHg, n = 6), followed by a significant increase in heart<br />
rate (115.0 +/- 12.7 bpm, n = 6). The alkaloid failed to induce tachycardia directly in isolated<br />
perfused rat heart. In isolated rat aortic rings, normacusine B antagonized phenylephrine and<br />
serotonin-induced contractions. Schild plot analysis of individual cumulative concentration-response<br />
curves was compatible with a competitive type of antagonism against phenylephrine (pA(2) = 7.05<br />
+/- 0.11) and of a non-competitive nature against 5-hydroxytryptamine (apparent pA(2) = 7.02 -<br />
0.08). Normacusine B was found inactive against KCl and PGF(2 alpha) induced contractions.<br />
Author<br />
Title<br />
Year<br />
Source title<br />
Reference<br />
Abstract<br />
Passarella, D., S. Sathyanarayana, M. Amat and J. Bosch<br />
Studies on <strong>the</strong> syn<strong>the</strong>sis of <strong>Strychnos</strong> alkaloids<br />
1996<br />
Natural Product Letters<br />
8(1): 75-82<br />
-<br />
Author<br />
Title<br />
Year<br />
Source title<br />
Reference<br />
Abstract<br />
Patir, S., P. Rosenmund and P. H. Goetz<br />
A new syn<strong>the</strong>tic route to <strong>the</strong> tetracyclic framework of strychnos alkaloids via intra<br />
1996<br />
Heterocycles<br />
43(1): 15-22<br />
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