Strychnos 1990 - 2004 - Crops for the Future

Author
Title
Year
Source title
Reference
Rafatro, H., R. K. Verbeeck, T. Y. R. Gougnard, P. J. M. De Jonghe, P. Rasoanaiv
Isolation from rat urine and human liver microsomes and identification by electros
2000
Journal of Mass Spectrometry
35(9) : 1112-1120
Abstract
Malagashanine has been isolated from indigenous madagasean Strychnos myrtoides alkaloids used
traditionally to treat malaria, This alkaloid was found to enhance the action of chloroquine against
chloroquine-resistant strains of Plasmodium falciparum when combined with classical antimalarial
drugs (chloroquine, quinine), The present study was carried out in order to investigate by
electrospray mass and tandem mass spectrometry and NMR spectroscopy the structure of two new
metabolites isolated from rat urine and human liver microsomes, We were able to demonstrate the
presence of two new metabolites of malagashanine corresponding to a malagashanine N-
demethylated metabolite and to the oxidation of malagashanine in the alpha-position of the N-methyl
group to produce a carbinolamine function. The latter metabolite may be subject to ring and openchain
tautomerism effects and dimeric species were detected in the electrospray mass spectrum.
C o p y r i g h t ( C ) 2 0 0 0 J o h n W i l e y & S o n s , L t d .
Author
Title
Year
Source title
Reference
Rukuni D
Analysis of fruit traits of Strychnos cocculoides: An important indigenous fruit tre
2000
Tree Seed News
2: 5-7
Abstract
An analysis is presented of fruit traits of Strychnos cocculoides collected from 18 provenances in
Zimbabwe. The fruits were characterized for fruit weight and diameter, weight of edible pulp, total
weight of seed, weight and thickness of shell, number of seeds per fruit, the percent total soluble
solids or brix, and 1000-seed weight. The ratio of the edible part of the fruit was also determined
based on measurements of the weight of internal fruit contents and total seed weight.