Strychnos 1990 - 2004 - Crops for the Future
Strychnos 1990 - 2004 - Crops for the Future
Strychnos 1990 - 2004 - Crops for the Future
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Author<br />
Title<br />
Year<br />
Source title<br />
Reference<br />
Frederich, M., M. Bentires-Ali, M. Tits, L. Angenot, E. Heinen and M. C. De Pau<br />
Apoptosis induction in human cancer cells by sungucine from <strong>Strychnos</strong> icaja root<br />
2003<br />
Naunyn-Schmiedebergs Archives of Pharmacology<br />
367(3): 260-265<br />
Abstract<br />
Sungucine (SG) and isosungucine (ISG) are bisindole alkaloids characterized by a 5'-23 link between<br />
<strong>the</strong> two parts of <strong>the</strong> compounds, which are till now specific to <strong>Strychnos</strong> icaja. In this work, SG and<br />
ISG were submitted to <strong>the</strong> NCI's in vitro 60 human tumor cell line screen, where SG showed<br />
interesting selectivity (6X) against <strong>the</strong> tested leukemia cell lines. In HL60-treated cells, apoptosis<br />
was demonstrated by observation of apoptotic bodies <strong>for</strong>mation, and phosphatidylserine exposition<br />
at cell surface. In HeLa-treated cells, <strong>the</strong> analysis of cellular cycle by flow cytometry showed G1<br />
accumulation and a small sub-G1 peak that could be related to DNA fragmentation characteristic of<br />
apoptosis. The eventual role of p53 was analyzed using wild-type HCT-116 colon cancer cells.<br />
Never<strong>the</strong>less, p53 and Bax expression were not modified in SG-treated cells. The cleavage of PARP<br />
by caspase-3 protease proved that apoptosis was also induced in this line. These results demonstrate<br />
that SG induces apoptosis, but also necrosis, in human cancer cell lines.<br />
Author<br />
Title<br />
Year<br />
Source title<br />
Reference<br />
Abstract<br />
Frederich, M., M. Bentires-Alj, M. Tits, L. Angenot, R. Greimers, J. Gielen, V. B<br />
Isostrychnopentamine, an indolomonoterpenic alkaloid from <strong>Strychnos</strong> usambaren<br />
2003<br />
Journal of Pharmacology and Experimental Therapeutics<br />
304(3): 1103-1119<br />
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