Strychnos 1990 - 2004 - Crops for the Future

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Author Title Year Source title Reference Abstract Cheng, M. J., I. L. Tsai and I. S. Chen Chemical constituents from Strychnos cathayensis 2001 Journal of the Chinese Chemical Society Taipei 48(2): 235-240 - Author Title Year Source title Reference Abstract Frederich, M., M. C. De Pauw, C. Prosperi, M. Tits, V. Brandt, J. Penelle, M. P. Strychnogucines a' and b, two new antiplasmodial bisindole alkaloids from Strych 2001 Journal of Natural Products 64(1): 12-16 - Author Title Year Source title Reference Frederich, M., M. P. Hayette, M. Tits, P. De Mol and L. Angenot Reversal of chloroquine and mefloquine resistance in Plasmodium falciparum by t 2001 Planta Medica 67(6): 523-527 Abstract Eight naturally occurring monoindole alkaloids were evaluated in vitro for their ability to inhibit Plasmodium falciparum growth and, in drug combination, to reverse the resistance of a chloroquineresistant strain of Plasmodium falciparum. None of these indole alkaloids has significant intrinsic antiplasmodial activity (IC50 > 10 muM or 5 mug/ml). Nevertheless, three alkaloids (icajine, isoretuline and strychnobrasiline) did reverse chloroquine resistance at concentrations between 2.5 and 25.4 g/ml (IF of 12.82 for isoretuline on W2 strain). The Interaction Factor (IF) equals 2, < 2, or > 2 for additive, antagonistic or synergistic effects of alkaloids on chloroquine inhibition, respectively. Icajine and isoretuline were also assessed in vitro for their mefloquine potentiating activity on a mefloquine-resistant strain of Plasmodium falciparum. Only icajine proved to be s y n e r g i s t i c w i t h m e f l o q u i n e ( I F = 1 5 . 3 8 ) .
Author Title Year Source title Reference Abstract Hilton, S. T., T. C. T. Ho, G. Pljevaljcic, M. Schulte and K. Jones A tandem radical approach to the abce-rings of the aspidosperma and strychnos al 2001 Chemical Communications- Royal Society of Chemistry (2): 209-210 - Author Title Year Source title Reference Abstract Ito, M., C. W. Clark, M. Mortimore, J. B. Goh and S. F. Martin Biogenetically inspired approach to the strychnos alkaloids. Concise syntheses of 2001 Journal of the American Chemical Society 123(33): 8003-8010 - Author Title Year Source title Reference Abstract Lambert, J. E. Red-tailed guenons (Cercopithecus ascanius) and Strychnos mitis: Evidence for pl 2001 International Journal of Primatology 22(2): 189-202 -
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