Strychnos 1990 - 2004 - Crops for the Future

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Author Title Year Source title Reference Xu, Y., K. Ohori, T. Ohshima and M. Shibasaki A practical large-scale synthesis of enantiomerically pure 3-[bis(methoxycarbonyl 2002 Tetrahedron 58(13): 2585-2588 Abstract A highly practical and efficient procedure for the large-scale (up to 6 mol) synthesis of enantiomerically pure (R)-3-[bis(methoxycarbonyl)methyl]cyclohexanone using an (R)- AlLibis(binaphthoxide) complex ((R)-ALB)-catalyzed asymmetric Michael reaction was developed. The reaction was successfully accelerated under highly concentrated conditions without lowering chemical yield or the high enantiomeric excess. Under these conditions, only 0.05 mol% of the catalyst forced the reaction to completion in 48 h. The work-up procedure was also improved and the enantiomerically pure compound was obtained as a white crystal in up to 95% yield without chromatographic separation. Finally, pre-manufacturing scale synthesis was performed. Using 0.1 mol% of the catalyst with 0.09 mol% of KO-t-Bu and MS 4 Angstrom, the Michael reaction of 2- cyclohexenone (6.0 mol, 581 mL) with dimethyl malonate (6.0 mol, 686 mL) was completed in 24 h at ambient temperature to afford more than a kilogram of the enantiomerically pure product in 91% yield after three successive crystallizations. The described method renders the enantiomerically pure Michael adduct readily available on greater than kilo scale. (C) 2002 Elsevier Science Ltd. All rights r e s e r v e d . Author Title Year Source title Reference Zhao, S., X. B. Liao and J. M. Cook Enantiospecific, stereospecific total synthesis of (+)-majvinine, (+)-10-methoxyaff 2002 Organic Letters 4(5): 687-690 Abstract [GRAPHICS] - The enantiospecific stereospecific total synthesis of majvinine la, 10- methoxyaffinisine 1b, and N-a-methylsarpagine 1c are reported; this method has also resulted in the total synthesis of the Alstonia bisindole macralstonidine 2.
Author Title Year Source title Reference Biswas, S., T. Murugesan, K. Maiti, L. Ghosh, M. Pal and B. P. Saha Study on the diuretic activity of Strychnos potatorum linn. Seed extract in albino r 2001 Phytomedicine 8(6): 469-471 Abstract Methanol extract of Strychnos potatorum Linn. seeds (SPSE) was evaluated for its diuretic activity in Wistar albino rats. The SPSE was administered at the graded doses of 200, 400, and 600 mg/kg body weight. The parameters which were taken into account during the experimental on each rat were: total urine volume (corrected for water intake during the test period), body weight before and after the experiment, and the concentration of sodium, potassium, and chloride ions in urine. The total urine volumes of the SPSE (600 mg/kg)-treated rats were evaluated nearly two and half fold then compared with the control (saline treated) group. Excretion of cations (sodium and potassium ions) and anions (chloride ions) also increased significantly with respect to the control group. The diuretic effect was comparable with that of the standard drug Furosemide. The increase of cations in the urine on treatment with Strychnos potatorum seed extract (SPSE) was dose-dependent. This effect supports the use of the Strychnos potatorum seeds as a diuretic in folk remedies. Author Title Year Source title Reference Brandt, V., M. Tits, J. Penelle, M. Frederich and L. Angenot Main glucosidase conversion products of the gluco-alkaloids dolichantoside and p 2001 Phytochemistry 57(5): 653-659 Abstract The enzymatic glucose cleavage of palicoside revealed the biosynthetic pathway to akagerine, whereas the conversion of dolichantoside led to a new quaternary heteroyohimbine alkaloid named N-b-methyl-21-beta -hydroxy-mayumbine. The hypothetical models of reactions occurring after the conversion of both substrates are proposed. Dolichantoside and palicoside, as well as Strychnos mellodora a stem bark crude ethanol extract, exhibit significant antimycotic activity against human pathogens in presence of specific glucosidase. (C) 2001 Elsevier Science Ltd. All rights reserved.
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Strychnos 1990 - 2004 - Crops for the Future

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