Strychnos 1990 - 2004 - Crops for the Future
Strychnos 1990 - 2004 - Crops for the Future
Strychnos 1990 - 2004 - Crops for the Future
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Author<br />
Title<br />
Year<br />
Source title<br />
Reference<br />
Mitaine-Offer, A. C., M. Sauvain, A. Valentin, J. Callapa, M. Mallie and M. Zech<br />
Antiplasmodial activity of aspidosperma indole alkaloids<br />
2002<br />
Phytomedicine<br />
9(2): 142-145<br />
Abstract<br />
The antiplasmodial activity of twelve alkaloids with an aspidospermane skeleton was estimated in<br />
vitro on chloroquine-resistant and sensitive strains of Plasmodium falciparum. Seven tetracyclic<br />
alkaloids possessing a free ethyl chain such aspidospermine, showed IC50 after incubation <strong>for</strong> 72 h<br />
between 3.2 and 15.4 muM. Moreover, four pentacyclic alkaloids with ethyl chain included in a<br />
tetrahydrofuran, such haplocine, showed a reduced activity, with IC50, after 72 h, between 22.6 and<br />
52.6 muM. According to <strong>the</strong>se results, a chloroquine-potentiating experiment was also per<strong>for</strong>med<br />
with two of <strong>the</strong> most active compounds. Isobolograms were obtained and demonstrated a synergic<br />
effect of N-<strong>for</strong>myl-aspidospermidine and aspidospermine when associated with chloroquine. The<br />
cytotoxicity and <strong>the</strong> selectivity index of some alkaloids were also estimated.<br />
Author<br />
Title<br />
Year<br />
Source title<br />
Reference<br />
Abstract<br />
Ohshima, T., J. Y. Xu, R. Takita, S. Shimizu, D. F. Zhong and M. Shibasaki<br />
Enantioselective total syn<strong>the</strong>sis of (-)-strychnine using <strong>the</strong> catalytic asymmetric m<br />
2002<br />
Journal of <strong>the</strong> American Chemical Society<br />
124(49): 14546-14547<br />
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