Strychnos 1990 - 2004 - Crops for the Future
Strychnos 1990 - 2004 - Crops for the Future
Strychnos 1990 - 2004 - Crops for the Future
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Author<br />
Title<br />
Year<br />
Source title<br />
Reference<br />
Wright, C. W., D. H. Bray, M. J. Oneill, D. C. Warhurst, J. D. Phillipson, J. Queti<br />
Antiamoebic and antiplasmodial activities of alkaloids isolated from <strong>Strychnos</strong> us<br />
1991<br />
Planta Medica<br />
57(4): 337-340<br />
Abstract<br />
Seven alkaloids isolated from <strong>Strychnos</strong> usambarensis have been assessed <strong>for</strong> in vitro activities<br />
against Entamoeba histolytica and Plasmodium falciparum and <strong>for</strong> in vivo activity against<br />
Plasmodium berghei in mice. Strychnopentamine and 3',4'-dihydrousambarensine were highly active<br />
against P. falciparum in vitro, but were inactive and non-toxic against P. berghei in vivo.<br />
Usambarensine, usambarine, and 18,19-dihydrousambarine were highly active against E. histolytica<br />
in vitro, but were less active against P. falciparum in vitro. N(b)-Methylusambarensine was less<br />
active against both protozoa than was usambarensine, and akagerine possessed little antiprotozoal<br />
activity. Structure-activity relationships are discussed in <strong>the</strong> context of <strong>the</strong> reported cytotoxic and<br />
p harmacological properties of <strong>the</strong>se alkaloids.<br />
Author<br />
Title<br />
Year<br />
Source title<br />
Reference<br />
Abstract<br />
Alvarez M; Salas M; Deveciana A; Lavilla R; Bosch J<br />
Nucleophilic-addition of indole-2-acetic ester enolates to n-alkylpyridinium salts -<br />
<strong>1990</strong><br />
Tetrahedron Letters<br />
31(35): 5089-5092<br />
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