Strychnos 1990 - 2004 - Crops for the Future

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Author Title Year Source title Reference Quetinleclercq, J., M. C. Depauwgillet, L. Angenot and R. Bassleer Effects of strychnopentamine on cells cultured in vitro 1991 Chemico-Biological Interactions 80(2): 203-216 Abstract This paper describes the powerful cytotoxic action exerted by strychnopentamine (SP), a dimeric indole alkaloid extracted from Strychnos usambarensis Gilg, on B16 melanoma cells and on noncancer human fibroblasts cultured in vitro. SP strongly inhibits cell proliferation and induces cell death at a relatively low concentration (< 1-mu-g/ml) after 72 h of treatment in the two lines. Incorporation of [H-3]thymidine and [H-3]leucine by B16 cells significantly decreases after only 1 h of treatment at 0.5-mu-g/ml. SP induces the formation of dense lamellar bodies and vacuolization in the cytoplasm, intense blebbing at the cell surface and various cytological alterations leading to cell d e a t h . Author Title Year Source title Reference Abstract Quetinleclercq, J., M. Tits, L. Angenot and N. G. Bisset Alkaloids of Strychnos usambarensis stem bark 1991 Planta Medica 57(5): 501-501 - Author Title Year Source title Reference Quetinleclercq, J., P. Coucke, C. Delaude, R. Warin, R. Bassleer and L. Angenot Matadine, a cytotoxic alkaloid from Strychnos gossweileri 1991 Phytochemistry 30(5): 1697-1700 Abstract Matadine, a new alkaloid, has been isolated from the root bark of Strychnos gossweileri. Elucidation of its structure is mainly based on 1D and 2D NMR studies. Its cytotoxic activity has b een tested in vitro on cancer cells and normal cells.
Author Title Year Source title Reference Rawal VH; Michoud C A general-solution to the synthesis of 2-azabicyclo[3.3.1]nonane unit of Strychnos 1991 Tetrahedron Letters 32(14): 1695-1698 Abstract The characteristic 2-azabicyclo[3.3.1]nonane substructure of Strychnos alkaloids can be constructed rapidly and stereospecifically using an intramolecular Heck reaction. Author Title Year Source title Reference Tits, M., J. Damas, J. Quetinleclercq and L. Angenot From ethnobotanical uses of Strychnos henningsii to antiinflammatories, analgesi 1991 Journal of Ethnopharmacology 34(2-3): 261-267 Abstract Strychnos henningsii Gilg is used in African traditional medicine for the treatment of various ailments, including rheumatism, gastrointestinal complaints and snake bites. Different preliminary pharmacological experiments are described. The results show that some of the reported folk medicinal applications of S. henningsii can be at least partially explained by the presence of retulinelike alkaloids, whose use could lead to new antinociceptive (antiinflammatory and analgesic) and a n t i s p a s m o d i c d r u g s .
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