Strychnos 1990 - 2004 - Crops for the Future
Strychnos 1990 - 2004 - Crops for the Future
Strychnos 1990 - 2004 - Crops for the Future
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Author<br />
Title<br />
Year<br />
Source title<br />
Reference<br />
Demedeiros, C. L. C., G. Thomas and R. Mukherjee<br />
The source of ca2+ <strong>for</strong> <strong>the</strong> spasmolytic actions of longicaudatine, a bisindole alkal<br />
1991<br />
Phyto<strong>the</strong>rapy Research<br />
5(1): 24-28<br />
Abstract<br />
Longicaudatine, a tertiary bisindole alkaloid isolated from <strong>the</strong> root bark of <strong>Strychnos</strong> trinervis (Vell.)<br />
Mart. (Loganiaceae), antagonized in a noncompetitive manner, carbachol and histamine induced<br />
contractions of <strong>the</strong> guinea-pig ileum and bradykinin responses in <strong>the</strong> rat uterus. The respective pD2'<br />
values (mean +/- SE) were 4.61 +/- 0.21, 4.98 +/- 0.04 and 4.49 +/- 0.01. Longicaudatine, unlike<br />
verapamil, had no effect on voltage dependent Ca2+ channels, as it failed to inhibit KCl or CaCl2<br />
induced contractions of guinea-pig ileum and depolarized rat uterus respectively. When compared<br />
with sodium nitroprusside, an antagonist of receptor operated Ca2+ channels, longicaudatine<br />
produced a slower and weaker inhibition of noradrenaline induced sustained contractions of rabbit<br />
aortic strips. However, in <strong>the</strong> aorta, <strong>the</strong> alkaloid antagonized <strong>the</strong> intracellular calcium dependent<br />
transient contractions of noradrenaline and longicaudatine (IC50, 5.01 x 10(-7) M) was<br />
approximately 133 times more potent that procaine (IC50, 6.68 x 10(-5) M), a known inhibitor of <strong>the</strong><br />
release of Ca2+ from intracellular stores. Longicaudatine may exert nonspecific spasmolytic effects<br />
by acting on intracellular Ca2+ stores, ra<strong>the</strong>r than on depolarization dependent or receptor operated<br />
C a 2 + c h a n n e l s .<br />
Author<br />
Title<br />
Year<br />
Source title<br />
Reference<br />
Abstract<br />
Fevig, J. M., R. W. Marquis and L. E. Overman<br />
Syn<strong>the</strong>sis applications of cationic aza-cope rearrangements .22. New approach to<br />
1991<br />
Journal of <strong>the</strong> American Chemical Society<br />
113(13): 5085-5086<br />
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