Strychnos 1990 - 2004 - Crops for the Future
Strychnos 1990 - 2004 - Crops for the Future
Strychnos 1990 - 2004 - Crops for the Future
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
Author<br />
Title<br />
Year<br />
Source title<br />
Reference<br />
Quetinleclercq, J., C. Coune, C. Delaude, R. Warin, R. Bassleer and L. Angenot<br />
Revision of <strong>the</strong> structure of strychnofluorine, an alkaloid of <strong>Strychnos</strong> gossweileri<br />
1992<br />
Phytochemistry<br />
31(12): 4347-4349<br />
Abstract<br />
The structure of strychnofluorine, an indole alkaloid isolated from <strong>the</strong> root bark of <strong>Strychnos</strong><br />
gossweileri has been revised. Strychnofluorine proved to be identical with 18-<br />
hydroxynorfluorocurarine. Fur<strong>the</strong>rmore, it has a low cytotoxic activity on B16 melanoma cells.<br />
Author<br />
Title<br />
Year<br />
Source title<br />
Reference<br />
Thomas, G., M. D. F. M. Diniz and R. Mukherjee<br />
Fur<strong>the</strong>r-studies on <strong>the</strong> antidiarrheal activity of bisnordihydrotoxiferine, a tertiary i<br />
1992<br />
Phyto<strong>the</strong>rapy Research<br />
6 (2): 84-88<br />
Abstract<br />
The dimeric tertiary indole alkaloid bisnordihydrotoxiferine isolated from <strong>the</strong> root bark of <strong>Strychnos</strong><br />
trinervis (Vell.) Mart. inhibited, on i.p. administration, Escherichia coli-induced diarrhoea and<br />
cholera toxin-stimulated intestinal fluid accumulation in mice. The respective ED50 values were<br />
10.6 and 20.0 mg/kg. The activity of bisnordihydrotoxiferine was unaffected by nalorphine or<br />
yohimbine, suggesting that <strong>the</strong> opioid and alpha-2-adrenoceptors respectively, are not important <strong>for</strong><br />
its antidiarrhoeal action. In smooth muscle studies, bisnordihydrotoxiferine antagonized in a<br />
noncompetitive and reversible manner, <strong>the</strong> contractions produced by histamine, acetylcholine and<br />
substance P in guinea-pig ileum and by 5-hydroxytryptamine and arachidonic acid in rat fundic strip.<br />
The respective pD2' values (mean +/- SEM) were 5.21 +/- 0.29, 5.20 +/- 0.29, 5.35 +/- 0.12, in <strong>the</strong><br />
ileum and 4.95 +/- 0.13 and 3.66 +/- 0.12 in <strong>the</strong> fundic strip. The values of slopes of <strong>the</strong> regression<br />
lines differed significantly from unity in all cases. Bisnor was inactive against PGE2-induced<br />
contractions in <strong>the</strong> ileum. The mechanism of action of <strong>the</strong> alkaloid may be related to nonspecific<br />
antagonism of gastrointestinal smooth muscle stimulant activity of several endogenous substances.