Strychnos 1990 - 2004 - Crops for the Future

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Author Title Year Source title Reference Massiot, G., P. Thepenier, M. J. Jacouier, L. Lemenolivier and C. Delaude Alkaloids from roots of Strychnos potatorum 1992 Phytochemistry 31(8): 2873-2876 Abstract Twenty-four compounds have been isolated and identified in the root bark of Strychnos potatorum. They are: Harmane carboxamide, cantleyine, 18,19-dihydrousambarensine, polyneuridine, norharmane, akuammidine, nor-C-flurorocurarine, ochrolifuanine A, bisnordihydrotoxiferine, ochrolifuanine E, normacusine B, normavacurine, henningsamine, 11-methoxyhenningsamine, dihydrolongicaudatine, dihydrolongicaudatine Y, antirhine, (20R)- and (20S)-dihydroantirhine, 11- methoxy-12-hydroxydiaboline, diaboline, 11-methoxydiaboline, desacetylretuline and diaboline N- o x i d e . T h e a l k a l o i d s i n i t a l i c a r e n o v e l . Author Title Year Source title Reference Abstract Mukherjee R Indole alkaloids of Strychnos from the northeast of Brazil 1992 Traditional medicine, Calcutta; India New Delhi, 229-234 pp - Author Title Year Source title Reference Abstract Pan, S. K. A study of anti-timira (anticataract) activity of katak (Strychnos potatorum) 1992 International Ayurveda conference; Musing ayurved, Pune, India Delhi, 129-138 pp -
Author Title Year Source title Reference Quetinleclercq, J., C. Coune, C. Delaude, R. Warin, R. Bassleer and L. Angenot Revision of the structure of strychnofluorine, an alkaloid of Strychnos gossweileri 1992 Phytochemistry 31(12): 4347-4349 Abstract The structure of strychnofluorine, an indole alkaloid isolated from the root bark of Strychnos gossweileri has been revised. Strychnofluorine proved to be identical with 18- hydroxynorfluorocurarine. Furthermore, it has a low cytotoxic activity on B16 melanoma cells. Author Title Year Source title Reference Thomas, G., M. D. F. M. Diniz and R. Mukherjee Further-studies on the antidiarrheal activity of bisnordihydrotoxiferine, a tertiary i 1992 Phytotherapy Research 6 (2): 84-88 Abstract The dimeric tertiary indole alkaloid bisnordihydrotoxiferine isolated from the root bark of Strychnos trinervis (Vell.) Mart. inhibited, on i.p. administration, Escherichia coli-induced diarrhoea and cholera toxin-stimulated intestinal fluid accumulation in mice. The respective ED50 values were 10.6 and 20.0 mg/kg. The activity of bisnordihydrotoxiferine was unaffected by nalorphine or yohimbine, suggesting that the opioid and alpha-2-adrenoceptors respectively, are not important for its antidiarrhoeal action. In smooth muscle studies, bisnordihydrotoxiferine antagonized in a noncompetitive and reversible manner, the contractions produced by histamine, acetylcholine and substance P in guinea-pig ileum and by 5-hydroxytryptamine and arachidonic acid in rat fundic strip. The respective pD2' values (mean +/- SEM) were 5.21 +/- 0.29, 5.20 +/- 0.29, 5.35 +/- 0.12, in the ileum and 4.95 +/- 0.13 and 3.66 +/- 0.12 in the fundic strip. The values of slopes of the regression lines differed significantly from unity in all cases. Bisnor was inactive against PGE2-induced contractions in the ileum. The mechanism of action of the alkaloid may be related to nonspecific antagonism of gastrointestinal smooth muscle stimulant activity of several endogenous substances.
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