Strychnos 1990 - 2004 - Crops for the Future

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Author Title Year Source title Reference Parsons, R. L., J. D. Berk and M. E. Kuehne Total syntheses of strychnan-type and aspidospermatan-type alkaloids .2. Generati 1993 Journal of Organic Chemistry 58(26): 7482-7489 Abstract The synthesis of N(b)-benzyl-2-(dimethyl 2-malonyl)- and 2-(methyl 2-acetyl)tryptamines (21, 25) provides access to methyl 4-(3-furanyl)-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole-5-carboxylate (12) and methyl 3-benzyl-5-(3-furanyl)-2,3,3a,4,5,7-hexahydro-1H-pyrrolo[2,3-d]carbazole-6- carboxylate (9), potential intermediates for the syntheses of strychnos alkaloids. A new condensationsigmatropic rearrangement reaction gives the tetracyclic product 9 directly from the tryptamine 25. Author Title Year Source title Reference Abstract Parsons, R. L., J. D. Berk and M. E. Kuehne Intermediates for Strychnos alkaloids 1993 Abstracts of Papers of the American Chemical Society 205(Mar): 186 - Author Title Year Source title Reference Quetinleclercq, J., B. Bouzahzah, A. Pons, R. Greimers, L. Angenot, R. Bassleer a Strychnopentamine, a potential anticancer agent. 1993 Planta Medica 59(1): 59-62 Abstract We analysed the effects of strychnopentamine, an alkaloid isolated from Strychnos usambarensis, on an Ehrlich ascites tumor growing in the mouse after inoculation. Four subcutaneous injections of 1. 5 mg strychnopentamine (1 per day) induce a significant decrease of the number of tumor cells and a significant increase of the survival of the treated mice. Observed side effects are partial haemolysis a n d s o m e l i v e r d a m a g e .
Author Title Year Source title Reference Abstract Rawal, V. H., C. Michoud and R. F. Monestel General strategy for the stereocontrolled synthesis of strychnos alkaloids - a conci 1993 Journal of the American Chemical Society 115(7): 3030-3031 - Author Title Year Source title Reference Solis, P. N., C. W. Wright, M. P. Gupta and J. D. Phillipson Alkaloids from Cephaelis dichroa 1993 Phytochemistry 33(5): 1117-1119 Abstract A new indole alkaloid, vallesiachotamine lactone, and four known compounds strictosidine, strictosamide, vallesiachotamine and angustine were isolated from the aerial parts of Cephaelis dichroa. Structures were established by spectroscopic methods (UV, IR, mass spectrometry, H-1 and C-13 NMR, including COSY 45 and H-1-C-13 heterocorrelation). Isovallesiachotamine was detected as a degradation product of vallesiachotamine.
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