Strychnos 1990 - 2004 - Crops for the Future
Strychnos 1990 - 2004 - Crops for the Future
Strychnos 1990 - 2004 - Crops for the Future
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Author<br />
Title<br />
Year<br />
Source title<br />
Reference<br />
Parsons, R. L., J. D. Berk and M. E. Kuehne<br />
Total syn<strong>the</strong>ses of strychnan-type and aspidospermatan-type alkaloids .2. Generati<br />
1993<br />
Journal of Organic Chemistry<br />
58(26): 7482-7489<br />
Abstract<br />
The syn<strong>the</strong>sis of N(b)-benzyl-2-(dimethyl 2-malonyl)- and 2-(methyl 2-acetyl)tryptamines (21, 25)<br />
provides access to methyl 4-(3-furanyl)-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole-5-carboxylate<br />
(12) and methyl 3-benzyl-5-(3-furanyl)-2,3,3a,4,5,7-hexahydro-1H-pyrrolo[2,3-d]carbazole-6-<br />
carboxylate (9), potential intermediates <strong>for</strong> <strong>the</strong> syn<strong>the</strong>ses of strychnos alkaloids. A new condensationsigmatropic<br />
rearrangement reaction gives <strong>the</strong> tetracyclic product 9 directly from <strong>the</strong> tryptamine 25.<br />
Author<br />
Title<br />
Year<br />
Source title<br />
Reference<br />
Abstract<br />
Parsons, R. L., J. D. Berk and M. E. Kuehne<br />
Intermediates <strong>for</strong> <strong>Strychnos</strong> alkaloids<br />
1993<br />
Abstracts of Papers of <strong>the</strong> American Chemical Society<br />
205(Mar): 186<br />
-<br />
Author<br />
Title<br />
Year<br />
Source title<br />
Reference<br />
Quetinleclercq, J., B. Bouzahzah, A. Pons, R. Greimers, L. Angenot, R. Bassleer a<br />
Strychnopentamine, a potential anticancer agent.<br />
1993<br />
Planta Medica<br />
59(1): 59-62<br />
Abstract<br />
We analysed <strong>the</strong> effects of strychnopentamine, an alkaloid isolated from <strong>Strychnos</strong> usambarensis, on<br />
an Ehrlich ascites tumor growing in <strong>the</strong> mouse after inoculation. Four subcutaneous injections of 1. 5<br />
mg strychnopentamine (1 per day) induce a significant decrease of <strong>the</strong> number of tumor cells and a<br />
significant increase of <strong>the</strong> survival of <strong>the</strong> treated mice. Observed side effects are partial haemolysis<br />
a n d s o m e l i v e r d a m a g e .
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