Allureâ¢ Acidix HPLC Column - Chromtech.com.au

More documents

Recommendations

Info

RAS[TM] -- Allure[TM] Basix HPLC Column NEW Allure Basix HPLC Column ● ● ● ● Maximum retention of basic (amino-containing) compounds Increased LC/MS sensitivity Excellent general purpose column Highly reproducible and stable HPLC Columns High Performance Liquid Chromatography/Mass Spectrometry (LC/MS) has developed into one of the most powerful analytical techniques available. Although the mass spectrometer can, in itself, provide enhanced selectivity, quality chromatographic separations are essential in order to garner the full advantages of the technique. Among the advantages of LC/MS technology is an increased level of sensitivity compared to that provided by traditional ultraviolet (UV) detection. The sensitivity achieved in the LC/MS system is related to the efficiency of the ionization/evaporation process. A greater percentage of organic modifier in the mobile phase improves the ionization/evaporation efficiency and thus provides increased sensitivity. The Allure family of HPLC columns has been designed to provide the retention and resolution required for successful LC/MS method development. Specifically, the Allure Basix phase has been engineered to produce maximum retention of basic (amino-containing) compounds using mobile phases with high organic percentages. For LC/MS applications, this unique ability translates into increased sensitivity for the target analytes. Therefore, the Allure Basix phase is an excellent column choice for pharmaceutical applications ranging from raw material analysis to metabolic studies. APPLICATIONS Figure 1 depicts the increased retention of the basic analyte amitriptyline at high organic percentages, as compared to the Allure C18 phase. At lower percentages of organic, hydrophobic interactions prevail and the C18 phase provides greater retention. As shown in Figure 2, the increase in retention at high organic content invokes polar interactions as the dominant separation mechanism, and produces significantly enhanced signal-to-noise (S/N) in the mass spectrometer -- nearly a 250% increase! Figure 1: Allure Basix Column Provides Increased Retention of Basic Compounds at http://www.restekcorp.com/basix/basix.htm (1 of 3) [12/7/01 8:56:47 PM]
RAS[TM] -- Allure[TM] Basix HPLC Column High Organic Mobile Phase Figure 3 demonstrates that the Allure Basix column is also an excellent choice for difficult as well as routine analyses. The series of tricyclic antidepressants exhibit excellent peak shape and are well resolved using a simple mobile phase. Application: Corticosteroids on Allure Basix SUMMARY The Allure Basix column is an ideal LC/MS column for the analysis of basic analytes. The column is reproducible, stable, and an excellent choice for routine analysis of basic compounds. Allure Basix HPLC Column Specialized for Basic Compounds Allure Basix Columns, 5µm, 60Å 2.1mm ID 3.2mm ID 4.6mm ID http://www.restekcorp.com/basix/basix.htm (2 of 3) [12/7/01 8:56:47 PM]
Page 1 and 2: Restek Advantage, Summer 1999: Allu
Page 3 and 4: Restek Advantage, Summer 1999: Inte
Page 5 and 6: Restek -- LC/MS Columns Restek HPLC
Page 7 and 8: Restek -- Ultra IBD Intrinsically B
Page 9 and 10: Restek -- Ultra IBD Intrinsically B
Page 11: Restek -- LC/MS Columns
Page 21 and 22: Restek Advantage, Fall 2000: Ultra
Page 23 and 24: Restek Advantage, Fall 2000: Ultra
Page 25 and 26: Restek -- HPLC Methods Development
Page 27 and 28: Restek -- HPLC Applications (PDF) H
Page 29 and 30: Restek -- HPLC Applications (PDF) C
Page 31 and 32: Ascorbic Acid on Allure Acidix (LC
Page 33 and 34: Adenine Nucleotides on Allure Acid
Page 35 and 36: Acetaminophen on Allure Acidix Pea
Page 37 and 38: Ibuprofen and Naproxin on Allure A
Page 39 and 40: Tricyclic Antidepressants on Allure
Page 41 and 42: Ibuprofen and 1 Application Note:00
Page 43 and 44: Timolol Maleate on Allure Basix Pe
Page 45 and 46: Metoprolol on Allure Basix Peak Li
Page 47 and 48: Cyclobenzaprine on Allure Basix Pe
Page 49 and 50: Norethindrone and 1 Application Not
Page 51 and 52: Sertraline HCI on Allure Basix Pea
Page 53 and 54: Verapamil HCL on Allure Basix Peak
Page 55 and 56: Atenolol on Allure Basix Peak List
Page 57 and 58: Trycyclic Antidepressants Applicati
Page 59 and 60: Norgestrel and Application Note: LC
Page 61 and 62: Norgestrel and Ethynyl Estradiol on
Page 63 and 64:
EPA Method 8330 Application Note:00
Page 65 and 66:
Benzaldehyde, Hydrocortisone, and P
Page 67 and 68:
Carbamates on Ultra IBD Peak List:
Page 69 and 70:
Thymine, Thymidine, TTP, TDP, and T
Page 71 and 72:
Cytosine, Cytidine, CTP, CDP, and C
Page 73 and 74:
11 Component Mixture of Nucleotides
Page 75 and 76:
LC/MS of Cephradine on Ultra IBD Ap
Page 77 and 78:
Cephaloridine by Normal Phase on Ul
Page 79 and 80:
Cephalexin and Cephradine on Ultra
Page 81 and 82:
Digoxin on Ultra IBD Peak List: 1.
Page 83 and 84:
Furosemide on Ultra IBD Peak List:
Page 85 and 86:
Acids and Bases @ pH3 Application N
Page 87 and 88:
Levothyroxine on Ultra PFP Peak Lis
Page 89 and 90:
EPA 8330 on Ultra Cyano Peak List:
Page 91 and 92:
Calcium Channel Blockers Applicatio
Page 93 and 94:
Organic Acids on Application Note:
Page 95 and 96:
Carbonyls Application Note:0036 1 2
Page 97 and 98:
Beclomethasone and des-chlorobeclom
Page 99 and 100:
β-Estradiol, Norethindrone and Eth
Page 101 and 102:
Restek Corporation -- Product Infor
show all

Allureâ¢ Acidix HPLC Column - Chromtech.com.au

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?

Allureâ¢ Acidix HPLC Column - Chromtech.com.au