PROCALCITONIN Evaluation & Use In Victoria, BC

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AUTOMATED ASSAYS Brahms Kryptor CL immunoassays All other assays under license from Brahms Calibrated against Brahms standards Licensed by Brahms; patent holder on PCT Roche ECL immunoassay BioMerieux Vidas CL immunoassay Siemens Centaur CL immunoassay Diasorin Liason CL immunoassay
INITIAL EVALUATION Objectives: Evaluate VIDAS & Roche assays Compare PCT to CRP (our prev.marker) Process: Collected 22 suspect sepsis + 2 without SIRS PCT (both assays) & CRP daily for 2-4 days Results compared to culture & clinical information from patients’ charts
Page 1 and 2: PROCALCITONIN Evaluation & Use In V
Page 3 and 4: SIRS & SEPSIS: SIRS Systemic Infla
Page 5 and 6: PHYSIOLOGY-1 PCT is the precursor
Page 7 and 8: THYROID C-CELL
Page 9 and 10: PHYSIOLOGY-2 Stimulated by bacteri
Page 11: CONTENTS SIRS, SEPSIS, PCT HISTORY
Page 15 and 16: 90 80 y = 0.8418x - 0.4055 R² = 0.
Page 17 and 18: CONTENTS SIRS, SEPSIS, PCT HISTORY
Page 19 and 20: INITIAL PCT AND CRP RESULTS CULTURE
Page 21 and 22: PCT v OTHER MKRS SOFA = Sequential
Page 23 and 24: THE VALUE OF PCT Decision to treat
Page 25 and 26: OTHER POSSIBLE VALUE Monitoring pat
Page 27: IMPLEMENTATION 3 month evaluation
Page 30 and 31: ACCEPTANCE OF TEST Generally good
Page 32 and 33: FALSE RESULTS False negatives not
Page 34 and 35: CONTENTS SIRS, SEPSIS, PCT HISTORY
Page 36 and 37: PCT v HRS AFTER BIRTH Brahms’ dat
Page 38 and 39: OTHER USES FOR PCT Prediction of r
Page 40: KEY REFERENCES 1. Mirjam Christ-Cra

PROCALCITONIN Evaluation & Use In Victoria, BC

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