Catherine M Roe WU CV 032212 - Institute for Public Health

Curriculum Vitae
Catherine M. Roe, PhD
Date: March 22, 2012
1. Personal Information: (optional)
2. Citizenship:
USA _X_____ Other ______
Visa Status / Type
3. Address and Telephone Numbers:
a. Office
Knight Alzheimer’s Disease Research Center
Department of Neurology
Washington University School of Medicine
4488 Forest Park Avenue, Suite 101
St. Louis, Missouri 63108
Phone: (314) 286-2435; Fax: (314) 286-2448
E-mail: cathyr@wubios.wustl.edu
b. Home
629 Landor Court
St. Louis, Missouri 63125
Telephone (314) 544-5832
4. Present Position:
Research Assistant Professor of Neurology
Knight Alzheimer’s Disease Research Center
Department of Neurology
2010-present
5. Education:
a. Undergraduate
BA, Purdue University
Major: Psychology
Minor: Mathematics
Awarded 1986
1

. Graduate
MA, Southern Illinois University
Majors: Clinical Psychology and Experimental Psychology
Awarded 1990
PhD, Southern Illinois University
Majors: Clinical Psychology and Experimental Psychology
Awarded 1992
c. Postgraduate
Postdoctoral Program
Washington University Clinical Research Training Center
Emphasis: Clinical research
Awarded 2010
6. Academic Positions / Employment:
1992 - 1993 Lecturer, Research Methods in Psychology, Psychopathology, and Child
Psychology, Southern Illinois University, Carbondale, Illinois
1993 - 1996 Director of Research, Masters and Johnson Sexual Trauma and Compulsivity
Programs, St. Louis, Missouri
1996 - 1999 Outcomes Researcher, Express Scripts, Inc., St. Louis, Missouri
1999 - 2002 Outcomes Research Manager, Express Scripts, Inc., St. Louis, Missouri
2002 - 2003 Statistical Data Analyst, Division of Biostatistics and Alzheimer’s Disease
Research Center, Washington University School of Medicine, St. Louis, Missouri
2003 – 2007 Research Statistician, Division of Biostatistics and Alzheimer’s Disease Research
Center, Washington University School of Medicine, St. Louis, Missouri
2007 - 2010 Research Instructor, Alzheimer’s Disease Research Center and Memory and
Aging Project, Department of Neurology, Washington University School of
Medicine, St. Louis, Missouri
2010 - Research Assistant Professor, Knight Alzheimer’s Disease Research Center and
Memory and Aging Project, Department of Neurology, Washington University
School of Medicine, St. Louis, Missouri
7. University and Hospital Appointments and Committees:
None
8. Medical Licensure and Board Certification:
None
9. Military Service: (optional)
a. Continuing military obligations
2

None
b. Status as a Vietnam Veteran
Not applicable
10. Honors and Awards:
2005 National Alzheimer’s Coordinating Center Junior Investigator Award
2007 National Institute on Aging 2007 Summer Institute on Aging Research
2009 Dorismae and Harvey A. Friedman Award for Excellence in Patient-Oriented
Care, Education, or Research on Aging or Aging Issues
11. Editorial Responsibilities:
Reviewer:
National Alzheimer’s Coordinating Center Scientific Review Committee (2011 –
present)
Ad Hoc Reviewer:
Journals:
Acta Neuropathologica
Aging Health
Alzheimer’s & Dementia
Alzheimer Disease and Associated Disorders
Archives of General Psychiatry
Archives of Neurology
BBA – Molecular Basis of Disease
Brain
Clinical Pharmacology and Therapeutics
Current Alzheimer Reports
European Journal of Neurology
Hospital Practice
International Journal of Geriatric Psychiatry
International Psychogeriatrics
The Journal of Neuropsychiatry and Clinical Neurosciences
Journal of Alzheimer’s Disease
Journal of Neurology
Journal of the American Geriatrics Society
Journal of the International Neuropsychological Society
Journal of Women’s Health
Neurobiology of Aging
Neurology
Population Studies
Psychiatry Research: Neuroimaging
Rejuvenation Research
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Proposals:
Alzheimer's Association International Research Grant Program
Barnes-Jewish Hospital Foundation/Washington University Institute of
Clinical and Translational Sciences Clinical and Translational
Research Funding Program
Cardiovascular Health Study Publications and Presentations Committee
Washington University Alzheimer’s Disease Research Center Pilot
Project Program
Washington University Center for Aging Pilot Project Program
12. Professional Societies and Organizations:
Academic Women’s Network at Washington University School of Medicine
Alvin J. Siteman Cancer Center
American Academy of Neurology
Association for Clinical Research Training
Alzheimer’s Association, Advocate
Geriatric Section – American Academy of Neurology
International Society to Advance Alzheimer's Research and Treatment
Washington University Institute of Clinical and Translational Sciences (ICTS)
Washington University Peer Group Mentoring Program for Women Faculty (2010-2011)
13. Major Invited Professorships and Lectureships:
Roe CM. Alzheimer’s and Cognitive Reserve: Effects with Amyloid Imaging. International
Neuropsychological Society, Acapulco Mexico, February 2010.
Roe CM. PreMCI, Alzheimer’s Disease, and Cognitive Reserve. Eighth Annual Mild
Cognitive Impairment Symposium, Miami Beach FL, March 2010.
14. Consulting Relationships and Board Memberships:
2011-present, Editorial Board, World Journal of Neurology.
2012-present, Editorial Board, Frontiers in Neurology
15. Research Support:
a. Governmental
P50 AG05681, Morris (PI) 05/01/05 – 04/30/10
Alzheimer’s Disease Research Center (ADRC) - The goal of this project is the
interdisciplinary neurobiological research and clinical analysis of Alzheimer’s disease
and other dementias.
Role: Investigator
P01 AG03991, Morris (PI) 01/01/04 – 12/31/08
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Healthy Aging and Senile Dementia (HASD) – The goal of this program project is the
investigation of the natural history of senile dementia of the Alzheimer type (SDAT)
including neurologic, psychiatric, psychometric and imaging data.
Role: Investigator
P01 AG026276, Morris (PI) 07/01/05 - 6/30/10
Antecedent Biomarkers for AD: The Adult Children Study. This program project will
examine potential antecedent biomarkers (CSF, blood, MRI, PIB PET, attention profile) in
a cohort of middle-aged adults with and without a demented parent.
Role: Investigator.
P50 AG05681-29 – PILOT 29.3, Roe (PI) 5/1/12-4/30/13
Driving Performance in Preclinical Alzheimer’s Disease. This pilot project will test the
feasibility of enrolling and testing novel predictors of driving performance among cognitively
normal adults with biomarker evidence of Alzheimer’s disease.
Role: Principle Investigator.
Completed Research Support
UL1RR024992, Polonsky (PI); K30 RR022251, Evanoff (PI) 7/1/2008-6/30/2010
NIH/NCRR
Washington University Institute of Clinical and Translational Sciences, Polonsky (PI)
Research Education, Training and Career Development, Fraser (Co-PI)
Clinical Research Training Center Postdoctoral Program.
Role: Scholar
U01 AG16976; Morris (Center Director) 7/1/2005-6/30/2006
U. of Washington (NIA)
National Alzheimer’s Coordinating Center Junior Investigator Award; Education, the
Cognitive Reserve Hypothesis, & Alzheimer's Disease without Dementia.
The proposed study will examine the role of education in presymptomatic AD within the
framework of the Cognitive Reserve hypothesis.
Role: Principle Investigator
b. Non-governmental
Longer Life Foundation, Roe (PI) 10/1/2011-9/30/2012
Improving Presymptomatic Detection of Alzheimer’s Disease
The major goal of this project is to determine whether the accuracy of imaging and
cerebrospinal fluid biomarkers for the identification of Alzheimer’s disease can be
improved by in including brain reserve, cognitive reserve, and other variables in
predictive equations.
Role: Principle Investigator
5

Completed Research Support
Goate (PI) 8/1/2004-7/31/2006
Siteman Cancer Center
γ-secretase activity as a modulator of cancer and Alzheimer disease risk.
This study seeks to identify alleles that may influence y-secretase activity and test
whether they influence risk for cancer and AD.
Role: Co-Investigator
Roe (PI) 6/1/2010 - 5/31/2011
BJHF/ICTS Clinical & Translational Research Funding Program
O*NET Occupational Dimension Scales in Alzheimer's Disease Research
Greater occupational complexity has been associated with lower risk of Alzheimer’s
disease and better cognitive functioning. This study examines the use of scales based
on the Occupation Information Network (O*NET) system to reflect occupational
complexity.
Role: Principle Investigator.
16. Patents
Co-inventor of the AD8 (Ascertaining Dementia 8), © 2006 Washington University
17. Clinical Title and Responsibilities:
None.
18. Teaching Title and Responsibilities:
None.
19. Bibliography:
a) Peer-reviewed manuscripts.
1. Roe CM, Motheral BR, Teitelbaum F, Rich MW. ACE inhibitor compliance and dosing
among patients with heart failure. American Heart Journal 1999;138:818-825.
2. Roe CM, Motheral BR, Teitelbaum F, Rich MW. Compliance and dosing of ACE
inhibitors before and after hospitalization. American Journal of Health-System
Pharmacy 2000;57:139-145.
3. Teitelbaum F, Roe CM, Fendrick AM. Pharmacy management trends: A guide for new
physicians. Seminars in Medical Practice 2000;3:29-39.
4. Roe CM, McNamara AM, Motheral BR. Gender- and age-related prescription drug use
patterns. The Annals of Pharmacotherapy 2002;36:30-39.
5. Roe CM, Heinle SM, Cox ER. Design of a three-tier benefit and cost trend. Drug Benefit
Trends 2002;14:21-22,24-26.
6. Roe CM, McNamara AM, Motheral BR. Use of chronic medications among a large,
commercially-insured US population. Pharmacoepidemiology and Drug Safety
2002;11:301-309.
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7. Roe CM, Anderson MJ, Spivack B. How many patients complete an adequate trial of
donepezil? Alzheimer Disease and Associated Disorders 2002;16:49-51.
8. Roe CM, Anderson MJ, Spivack B. Use of anticholinergic medications among older
adults with dementia. Journal of the American Geriatrics Society 2002;50:836-842.
9. Roe CM, Odell KW, Henderson RR. Concomitant use of antipsychotics and drugs that
may prolong the QT interval. Journal of Clinical Psychopharmacology 2003;23:197-200.
10. Roe CM, Anderson MJ, Spivack B. Use of anticholinergic medications among older
adults with dementia. In: Vellas B, Fitten LJ, Winbald B, Feldman H, Grundman M,
Giacobini E, Kurz A. (Eds). Research and Practice in Alzheimer’s Disease and Cognitive
Decline 2003 (Volume 7). New York: Springer Publishing Company, 2003, pp. 132-137.
11. Duchek JM, Carr DB, Hunt L, Roe CM, Xiong C, Shah K, Morris JC. Longitudinal Driving
Performance in Early-Stage Dementia of the Alzheimer Type. Journal of the American
Geriatrics Society 2003; 51:1342-1347.
12. Pastor P, Roe CM, Villegas A, Bedoya G, Chakraverty S, García G, Tirado V, Norton J,
Ríos S, Martínez M, Kosik K, Lopera F, Goate AM. APOE Є4 modifies age of onset in a
large E280A PS1 Alzheimer’s Disease kindred. Annals of Neurology 2003;54:163-169.
13. Shah K, Carr DB, Roe CM, Miller JP, Coats M, Morris JC. Impaired physical
performance and the assessment of Dementia of the Alzheimer’s Type. Alzheimer
Disease and Associated Disorders 2004;18:112-119.
14. Roe CM, Behrens MI, Xiong C, Miller JP, Morris JC. Alzheimer’s disease and cancer.
Neurology 2005;64:895-898.
15. Burns JM, Galvin JE, Roe CM, Morris JC, McKeel DW. The substantia nigra in
Alzheimer’s disease with extrapyramidal signs. Neurology 2005;64:1397-403.
16. Galvin JE, Roe CM, Powlishta KK, Coats MA, Muich SJ, Grant E, Miller JP, Storandt M,
Morris JC. The AD8: A brief informant interview to detect dementia. Neurology
2005;65:559-564.
17. Wilkins CH, Sheline YI, Roe CM, Birge SJ, Morris JC. Vitamin D deficiency associated
with low mood and worse cognitive performance in older adults. Am J Geriatr Psychiatry
2006;14:1032-1040.
18. Galvin JE, Roe CM, Xiong C, Morris JC. The validity and reliability of the AD8.
Neurology 2006;67:1942-1948.
19. Fagan AM, Roe CM, Xiong C, Mintun MA, Morris JC, Holtzman DM. Cerebrospinal fluid
biomarkers of early stage Alzheimer’s disease predict future dementia in cognitively
normal older adults. Archives of Neurology 2007;64:343-349.
20. Roe CM, Xiong C, Miller JP, Morris JC. Education and Alzheimer’s disease without
dementia: support for the Cognitive Reserve Hypothesis. Neurology 2007;68:223-228.
21. Galvin JE, Roe CM, Morris JC. Evaluation of cognitive impairment in the older adult:
combining brief informant and performance measures. Archives of Neurology
2007;64:718-724.
22. Galvin JE, Roe CM, Morris JC. Patient's rating of cognitive ability: using the AD8, a brief
informant interview as a self rating tool to detect dementia. Archives of Neurology
2007;64:725-730.
23. Khandelwal A, Chandu D, Roe CM, Kopan R, Quatrano RS. Moonlighting activity of
presenilin in plants is independent of γ-secretase and evolutionarily conserved.
Proceedings of the National Academy of Science USA 2007;104:13337-13342.
24. Fagan AM, Roe CM, Xiong C, Mintun MA, Morris JC, Holtzman DM. Medication use as a
confounding factor in the use of the cerebrospinal fluid tau/-amyloid42 ratio—reply.
Archives of Neurology 2007;64:1357 - 1359.
25. Roe CM, Xiong C, Grant E, Miller JP, Morris JC. Education and reported onset of
symptoms among individuals with Alzheimer’s disease. Archives of Neurology
2008;65:108-111. PMCID: PMC2830808
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26. Roe CM, Xiong C, Miller JP, Cairns NJ, Morris JC. Interaction of neuritic plaques and
education predicts dementia. Alzheimer Disease and Associated Disorders 2008;22:188-
193. PMCID: PMC2770714
27. Roe CM, Mintun MA, D’Angelo G, Xiong C, Grant E, Morris JC. Alzheimer’s and
cognitive reserve: variation of education effect with carbon 11-labled Pittsburgh
Compound B. Archives of Neurology 2008;65:1467-1471. PMCID: PMC2752218
28. Snider BJ, Fagan AM, Roe C, Shah AR, Grant EA, Xiong C, Morris JC, Holtzman DM.
CSF biomarkers predict rate of cognitive decline in very mild dementia of the Alzheimer’s
type. Archives of Neurology 2009;66:638-645. PMCID: PMC2759394
29. Behrens MI, Lendon C, Roe CM. A common biological mechanism in cancer and
Alzheimer’s disease? Current Alzheimer Research 2009:6:196-204. PMCID:
PMC2810550
30. Williams MM, Roe CM, Morris JC. Stability of the Clinical Dementia Rating: 1979-2007.
Archives of Neurology 2009;66:773-777. PMCID: PMC2779108
31. Price JL, McKeel Jr DW, Buckles VD, Roe CM, Xiong C, Grundman M, Hansen LA,
Petersen PC, Parisi JE, Dickson DW, Smith CD, Davis DG, Schmitt FA, Markesbery
WR, Kaye J, Kurlan R, Hulette C, Kurland BF, Higdon R, Kukull W, Morris JC.
Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer
disease. Neurobiol Aging 2009;30:1026-1036. PMCID: PMC2737680
32. Morris JC, Roe CM, Grant EA, Head D, Storandt M, Goate AM, Fagan AM, Holtzman
DM, Mintun MA. PIB Imaging Predicts Progression to Symptomatic Alzheimer’s Disease.
Arch Neurol 2009;66:1469-1475.
33. Fagan AM, Mintun MA, Shah AR, Aldea P, Roe CM, Mach RH, Marcus D, Morris JC,
Holtzman DM. Cerebrospinal fluid tau and ptau 181 increase with cortical amyloid
deposition: implications for future clinical trials of Alzheimer’s disease. EMBO Molecular
Medicine 2009;1:371-380. PMCID: PMC2806678
34. Harper P, Roe CM. Thyroid disease medication and subsequent development of
dementia of the Alzheimer type. J Geriatr Psychiatry Neurol 2010;23:63-69.
35. Wilkins CH, Roe CM, Morris JC. A brief clinical tool to assess physical function in mild
dementia: the Mini-PPT. Archives of Gerontology and Geriatriatrics 2010;50:96-100.
36. Roe CM, Fitzpatrick AL, Xiong C, Sieh W, Kuller L, Miller JP, Williams MM, Kopan R,
Behrens MI, Morris JC. Cancer linked to Alzheimer’s disease but not vascular dementia.
Neurology 2010;74:106-112. PMCID: PMC2809029
37. Morris JC, Roe CM, Xiong C, Fagan AM, Goate AM, Holtzman DM, Mintun MA. APOE
genotype predicts Aβ but not tau pathology in cognitively normal aging: amyloid imaging
and CSF biomarkers in preclinical Alzheimer’s disease. Annals of Neurology
2010;67:122-131. PMCID: PMC2830375
38. Palmer JL, Coats M, Roe CM, Xiong C, Hanko SM, Morris JC. Advance Practice Nurse
and Neurologist Agreement on the United Parkinson's Disease Rating Scale and
Physical/ Neurological Exam. Journal of Advanced Nursing 2010;66:1382-1387. PMCID:
PMC2903978.
39. Dreyfus DM, Roe CM, Morris JC. Autobiographical memory task in assessing dementia.
Arch Neurol 2010;67:862-866.
40. Behrens MI, Roe CM, Quest FG, Morris JC. Is there a link between dementia and
cancer? Aging Health 2010;6:361-364.
41. Roe CM, Mintun MA, Ghoshal N, Williams MM, Grant EA, Marcus DS, Morris JC.
Enhanced identification of Alzheimer’s disease using amyloid imaging: proof of concept.
Neurology 2010;75:42-48. PMCID: PMC2906402.
42. Kinnunen PJ, Tavares AR, de Melo AC, Sternberg C, Burke WJ, Roe CM, Morris JC,
Fitzpatrick AL, Behrens MI, Bennett DA. Cancer linked to Alzheimer disease but not
vascular dementia. Neurology 2010;75:1215-1217. PMC Journal - In Process.
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43. Craig-Schapiro R, Perrin RJ, Roe CM, Xiong C, Grant EA, Carter D, Cairns NJ, Mintun
MA, Peskind ER, Li G, Galasko DR, Clark CM, Quinn JF, D’Angelo G, Malone JP,
Townsend RR, Morris JC, Fagan AM, Holtzman DM. YKL-40: A Novel Diagnostic and
Prognostic Fluid Biomarker for Preclinical and Early Alzheimer’s Disease. Biological
Psychiatry 2010;68(10):903-912.
44. Perrin RJ, Craig-Shapiro R, Malone JP, Shah AR, Gilmore P, Davis AE, Roe CM,
Peskind ER, Li G, Galasko DR, Clark CM, Quinn JF, Kaye JA, Morris JC, Holtzman DM,
Townsend RR, Fagan AM. Identification and validation of novel cerebrospinal fluid
biomarkers of staging early Alzheimer’s disease. PLoS ONE 2011; 6:e16032 PMCID:
PMC3020224
45. Roe CM, Fagan AM, Williams MM, Ghoshal N, Aeschleman M, Grant EA, Marcus DS,
Mintun MA, Holtzman DM, Morris JC. Improving CSF Biomarker Accuracy in Predicting
Prevalent and Incident Alzheimer’s Disease. Neurology 2011;76(6):501-510. PMCID:
PMC3053181.
46. Roe CM, Fagan AM, Grant EA, Marcus DS, Benzinger TLS, Mintun MA, Holtzman DM,
Morris JC. Cerebrospinal fluid biomarkers, education, brain volume, and future cognition.
Archives of Neurology 2011;68:1145-1152. PMCID: PMC3203689.
47. Xiong C, Roe CM, Buckles V, Fagan AM, Holtzman D, Balota D, Duchek J, Storandt M,
Mintun M, Grant E, Head D, Benzinger T, Csernansky J, Morris J. Family history of
Alzheimer disease influences biomarker abnormalities in the Adult Children Study.
Archives of Neurology Arch Neurol. 2011 Oct; 68(10):1313-9. NIHMS 333549.
48. Yang YH, Roe CM, Morris JC. Relationships between late-life hypertension, blood
pressure, and Alzheimer’s disease. American Journal of Alzheimers Disease & Other
Dementias. (In press).
49. Behrens MI, Silva M, Salech F, Merino D, Ponce DP, Sinning M, Xiong C, Roe CM,
Quest AFG. Differential H2O2 –induced death of lymphocytes in patients with Alzheimer
and skin cancer. Journal of Gerontology: Biological Sciences. (In press).
50. Williams MM, Storandt M, Roe CM, Morris JC. Progression of Alzheimer Dementia as
Measured by Clinical Dementia Rating Sum of Boxes Scores. Alzheimer’s & Dementia
(In press).
b) Invited publications (e.g., reviews, book chapters, etc)
None
c) Movies, videotapes, etc.
None.
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