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A Brief History of Microbiology Learning Outcomes

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Slide 19<br />

Slide 20<br />

Koch’s Postulates<br />

• The same pathogen must be<br />

present in every case <strong>of</strong> the<br />

disease<br />

• The pathogen must be isolated<br />

from the diseased host and<br />

grown in pure culture<br />

• The pathogen from the pure<br />

culture must cause the disease<br />

when it is inoculated into a<br />

healthy, susceptible animal<br />

• The pathogen must be isolated<br />

from the inoculated animal and<br />

must be shown to be the<br />

original organism<br />

Biol 240 S06 19<br />

• Observed mortality<br />

rate <strong>of</strong> mothers<br />

higher when attended<br />

by doctors<br />

• puerperal fever<br />

• Hypothesis: docs<br />

transmitting disease<br />

on unwashed hands<br />

Semmelweis<br />

Biol 240 S06 20<br />

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