Hirsutism & Virilization

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2. Degree to which hair follicles are sensitive to androgens and able to convert vellus hairs to terminal hairs. 3. Degree of 5 ɑ-reductase activity in the skin, which determines local androgen activity. 4. Ratio of growth to resting phases in affected hair follicles. 5. Thickness and degree to which individual hairs are pigmented.
Pathophysiology of <strong>Hirsutism</strong> • A combination of the following factors results in hirsutism: 1. Increased concentration of serum androgens, especially free testosterone. 2. Decreased levels of SHBG, resulting in increased bioavailable androgen. 3. Increased activity of 5 ɑ-reductase.
Page 2 and 3: By Prof.Dr. Nabil Lymon Head of Int
Page 4 and 5: Virilization: • Is hirsutism asso
Page 6 and 7: Types of Hair 1. Lanugo hair: It is
Page 10 and 11: Sources of androgens in females:
Page 12 and 13: I- Testosterone • Total testoster
Page 14 and 15: II- Sex Hormone-Binding Globulin (S
Page 16 and 17: III- 5 α-Reductase • 5 α-Reduct
Page 18 and 19: Diagnosis of Hirsutism
Page 20 and 21: 2) Presence or absence of virilizat
Page 22 and 23: Differential Diagnosis of Hirsutism
Page 24 and 25: a) The fundamental pathophysiologic
Page 26 and 27: 2- Idiopathic hirsutism: • This c
Page 28 and 29: 4- Cushing syndrome: • Adrenocort
Page 30 and 31: 6- Disorders of pituitary origin
Page 32 and 33: Laboratory Evaluation of Hirsutism
Page 34 and 35: 2) Serum DHEAS (a marker of adrenal
Page 36 and 37: 5) Oestrogen levels. Estradiol is u
Page 38 and 39: Treatment
Page 40 and 41: • Suppression of androgen synthes
Page 42 and 43: • Androgen-receptor blockers: •

Hirsutism & Virilization

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