Hirsutism & Virilization
Hirsutism & Virilization
Hirsutism & Virilization
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3- Non classical (adult-onset) adrenal<br />
hyperplasia:<br />
• This condition is present in approximately 1%<br />
of hyperandrogenic women.<br />
• There is deficiency in activity of adrenal<br />
enzymes and thus formation of excess cortisol<br />
precursors (e.g., 17-hydoxyprogesterone and<br />
androstenedione) which leads to increased<br />
production of androgens. The most common<br />
enzyme deficiency is 21-hydroxylase.<br />
• Inheritance is autosomal recessive, and<br />
occurrence is increased in Ashkenazi Jews.