Hirsutism & Virilization

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a) The fundamental pathophysiologic defect is not known. b) Increased production of androgens may result from: • Increased secretion of luteinizing hormone (LH) from the anterior pituitary, leading to increased ovarian androgne production. • Insulin resistance and compensatory hyperinsulinemia, stimulate ovarian and adrenal androgen production by direct and indirect mechanisms.
c) Gonadotropin regulation of the menstrual cycle is disrupted, leading to oligo-ovulation or anovulation and menstrual irregularity. d) Increased androgen levels inhibit follicular development in the ovary; thus, multiple. Peripheral, small atretic follicles are produced. These “polycystic ovaries” are therefore a reflection of the hormonal environment within the ovary rather than the cause of the disorder. e) Affected patients are at increased risk for endometrial hyperplasia or cancer, glucose intolerance, type 2 diabetes mellitus, hyperlipidemia, and cardiovascular disease.
Page 2 and 3: By Prof.Dr. Nabil Lymon Head of Int
Page 4 and 5: Virilization: • Is hirsutism asso
Page 6 and 7: Types of Hair 1. Lanugo hair: It is
Page 8 and 9: 2. Degree to which hair follicles a
Page 10 and 11: Sources of androgens in females:
Page 12 and 13: I- Testosterone • Total testoster
Page 14 and 15: II- Sex Hormone-Binding Globulin (S
Page 16 and 17: III- 5 α-Reductase • 5 α-Reduct
Page 18 and 19: Diagnosis of Hirsutism
Page 20 and 21: 2) Presence or absence of virilizat
Page 22 and 23: Differential Diagnosis of Hirsutism
Page 26 and 27: 2- Idiopathic hirsutism: • This c
Page 28 and 29: 4- Cushing syndrome: • Adrenocort
Page 30 and 31: 6- Disorders of pituitary origin
Page 32 and 33: Laboratory Evaluation of Hirsutism
Page 34 and 35: 2) Serum DHEAS (a marker of adrenal
Page 36 and 37: 5) Oestrogen levels. Estradiol is u
Page 38 and 39: Treatment
Page 40 and 41: • Suppression of androgen synthes
Page 42 and 43: • Androgen-receptor blockers: •

Hirsutism & Virilization

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