Hirsutism & Virilization

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II- Sex Hormone-Binding Globulin (SHBG) A. Factors that decrease plasma SHBG 1. Obesity. 2. Increased androgen production. 3. Hyperinsulinemia. 4. Hyperprolactinaemia. 5. Corticosteroid therapy. 6. Hypothyroidism. 7. Acromegaly.
B. Factors that increase plasma SHBG 1. Estrogen therapy. 2. Pregnancy. 3. Hyperthyroidism. 4. Liver cirrhosis. • In general, hirsute women have reduced serum concentrations of SHBG.
Page 2 and 3: By Prof.Dr. Nabil Lymon Head of Int
Page 4 and 5: Virilization: • Is hirsutism asso
Page 6 and 7: Types of Hair 1. Lanugo hair: It is
Page 8 and 9: 2. Degree to which hair follicles a
Page 10 and 11: Sources of androgens in females:
Page 12 and 13: I- Testosterone • Total testoster
Page 16 and 17: III- 5 α-Reductase • 5 α-Reduct
Page 18 and 19: Diagnosis of Hirsutism
Page 20 and 21: 2) Presence or absence of virilizat
Page 22 and 23: Differential Diagnosis of Hirsutism
Page 24 and 25: a) The fundamental pathophysiologic
Page 26 and 27: 2- Idiopathic hirsutism: • This c
Page 28 and 29: 4- Cushing syndrome: • Adrenocort
Page 30 and 31: 6- Disorders of pituitary origin
Page 32 and 33: Laboratory Evaluation of Hirsutism
Page 34 and 35: 2) Serum DHEAS (a marker of adrenal
Page 36 and 37: 5) Oestrogen levels. Estradiol is u
Page 38 and 39: Treatment
Page 40 and 41: • Suppression of androgen synthes
Page 42 and 43: • Androgen-receptor blockers: •

Hirsutism & Virilization

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