BEVACIZUMAB EFFECT ON TOPOTECAN PHARMACOKINETICS ...

Table 5.
Population PK parameters of TPT estimated after SDBT
Groups # T 1D BT 3D BT 7D BT
Parameters Mean SD IIV Mean SD IIV Mean SD IIV Mean SD IIV
Ke (1/h) 0.448 0.120 26.7 1.51 0.760 50.3 1.07 0.819 76.6 1.06 0.804 76.0
Vc (L/m 2 ) 14.1 3.71 26.2 12.7 6.66 52.4 13.7 9.33 68.2 12.6 6.93 54.8
Kcp (1/h) 0.627 0.448 71.4 1.59 1.57 99.2 1.32 1.33 100 0.604 0.700 116
Kpc (1/h) 0.588 0.0600 10.2 0.344 0.0987 28.6 0.791 0.631 79.7 0.667 0.0600 9.00
Kct (1/h) 2.11 0.395 18.7 1.48 0.288 19.5 1.83 0.706 38.6 1.42 0.194 13.6
Kte (1/h) 4.61 1.04 22.5 16.3 7.07 43.4 6.03 3.56 59.1 6.45 0.500 7.74
Vt (L/m 2 ) 2.12 0.239 11.3 0.307 0.173 56.4 1.78 1.36 76.6 1.50 0.399 26.6
MLEM program was used in this population modeling for each individual group. Mean and SD refer to population mean and
population standard deviation; IIV refers to inter-individual variability as of %CV.
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