BEVACIZUMAB EFFECT ON TOPOTECAN PHARMACOKINETICS ...

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Figure 5. Representative plasma and tumor disposition of TPT with/without SDBT in mice bearing Rh30 RMS xenograft Representative unbound TPT concentration-time plots in tumor ECF ( ) and plasma ( ) in Rh30 rhabdomyosarcoma xenograft mice were shown above. Compared to the three compartmental PK model, the modified multi-compartmental PK model significantly (p
Figure 6. Representative plasma and tumor disposition of TPT with/without MDBT in mice bearing Rh30 RMS xenograft Representative unbound TPT concentration-time plots in tumor ECF ( ) and plasma ( ) in Rh30 rhabdomyosarcoma xenograft mice were shown above. Compared to the three compartmental PK model, the modified multi-compartmental PK model significantly (p
Page 1 and 2: BEVACIZUMAB EFFECT ON TOPOTECAN PHA
Page 3 and 4: ACKNOWLEDGEMENTS I would like to th
Page 5 and 6: overall effect of BEV on TPT pharma
Page 7 and 8: 2.3.1 The effect of BEV on the phar
Page 9 and 10: LIST OF FIGURES Figure 1. TPT effic
Page 11 and 12: SDBT Single dose of bevacizumab tre
Page 13 and 14: hypertension and the pathologic ext
Page 15 and 16: 1.1.3 Strategies to improve drug pe
Page 17 and 18: 1.2.2 Role of vascular endothelial
Page 19 and 20: enhanced the tumor response to conv
Page 21 and 22: non-favorable sites [109]. So devel
Page 23 and 24: low sensitivity. Additionally, it r
Page 25 and 26: tumor distribution of TMZ in V+ SC
Page 27 and 28: over-pruned microvessel [146, 147].
Page 29 and 30: 1.7 Summary Although the overall su
Page 31 and 32: CHAPTER 2. THE EFFECT OF BEVACIZUMA
Page 33 and 34: 2.2.4 Tumor model and treatment Ort
Page 35 and 36: Table 1. (SDBT) TPT penetration stu
Page 37 and 38: Figure 2. TPT penetration plus effi
Page 39 and 40: Figure 3. A pharmacokinetic model f
Page 41: 2.2.10 Statistical analyses For eac
Page 45 and 46: Figure 7. The effect of BEV on the
Page 47 and 48: Figure 8. The effect of BEV on the
Page 49 and 50: Table 6. Population PK parameters o
Page 51 and 52: variability for Kte decreased from
Page 53 and 54: Figure 11. The effect of different
Page 55 and 56: efflux transporters. TPT is a campt
Page 57 and 58: Furthermore, although the volume of
Page 59 and 60: 19. Sleeman, J., A. Schmid, and W.
Page 61 and 62: 56. ElBayoumi, T.A. and V.P. Torchi
Page 63 and 64: 91. Ma, J. and D.J. Waxman, Combina
Page 65 and 66: 125. Hao, M., et al., Pharmacokinet
Page 67 and 68: 154. Dickson, P.V., et al., Bevaciz
Page 69 and 70: 188. Tian, Q., et al., Topotecan is

BEVACIZUMAB EFFECT ON TOPOTECAN PHARMACOKINETICS ...

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