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BEVACIZUMAB EFFECT ON TOPOTECAN PHARMACOKINETICS ...

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ACKNOWLEDGEMENTS<br />

I would like to thank my mentor, Dr. Clinton F. Stewart, for the opportunity to<br />

learn from his vast knowledge and work in his laboratory. I also would like to express my<br />

appreciation for his help, guidance, suggestion and encouragement throughout my study,<br />

research and writing of this thesis. He is an incredible good mentor and career guider.<br />

My sincere gratitude is also extended to the other members of my thesis<br />

committee: Drs. John C. Panetta and Bernd Meibohm for serving on my committee and<br />

their excellent suggestion, comments and guidance for this project. Especially, I want to<br />

express my deepest gratitude to Dr. John C. Panetta for helping me with the population<br />

modeling of this project. Without his help, I cannot accomplish this part of the work. I<br />

also would like to thank Dr. Andrew M. Davidoff for providing the Rh30 cell line used in<br />

this study.<br />

In addition, I would like to thank to all the members and friends in the Stewart<br />

laboratory. I would like to acknowledge my supervisor Dr. Stacy Throm and co-worker<br />

Dr. Fan Wang for their patience, guidance and support during the project progress and<br />

writing of the thesis. Thanks to the former post-docs Dr. Michael Tagen, Angel M.<br />

Carcaboso and the former supervisor Laura Miller for their constant support and help.<br />

I’m also grateful to co-workers and friends Dr. Feng Bai, Dr. Fan Zhang, Mohamed<br />

Elmeliegy, Thandranese Owens, Dr. Steven Zatechka, Daniel Groepper, and Dr. Vamshi<br />

Manda for their support and friendship throughout the project.<br />

At last, I also would like to gratefully acknowledge the care and support of my<br />

husband and parents, who always encouraged me on the way along.<br />

iii

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