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EEG and Brain Connectivity: A Tutorial - Bio-Medical Instruments, Inc.

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it requires essentially zero energy to change the phase relationship between<br />

coupled oscillators <strong>and</strong> by this process rapidly create synchronized clusters<br />

of neural activity. In addition to phase reset without any change in<br />

frequency or amplitude of the <strong>EEG</strong> spectrum is that it can also be<br />

independent of phase history. That is, phase reset occurs independent of<br />

magnitude <strong>and</strong> direction of the phase difference that existed before the onset<br />

of the reset pulse (Kazantsev et al, 2004). What is important in the<br />

computation of the first derivative of the time series of phase is the rate of<br />

change of phase over time <strong>and</strong> not the absolute magnitude of phase.<br />

Figure 11 shows the relationship between phase differences using Cz<br />

as a reference <strong>and</strong> phase reset as measured by the 1 st derivative of the phase<br />

difference time series.<br />

Fig. 11 – Example of phase difference time series with Cz as the reference (Top) <strong>and</strong> the<br />

1 st derivative of the phase difference time series (Bottom) or phase reset. Analyses were<br />

produced using the NeuroGuide Lexicor demo from the download at<br />

www.appliedneuroscience.com<br />

Figure 12 shows examples of phase synchrony or phase locking when<br />

the first derivative of the phase difference time series ≈ 0 <strong>and</strong> phase reset

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