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EEG and Brain Connectivity: A Tutorial - Bio-Medical Instruments, Inc.

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phase reset are that minimal energy is required to reset phase between<br />

weakly coupled oscillators <strong>and</strong> phase reset occurs independent of amplitude.<br />

In weakly coupled chaotic systems amplitude can vary r<strong>and</strong>omly while<br />

phase locking is stable.<br />

Phase reset is defined as a significant positive or negative first<br />

derivative of the time series of phase difference between two channels, i.e.,<br />

d( ϕ<br />

t<br />

− ϕ′<br />

t<br />

_/t > 0 or < 0. Phase locked or phase synchrony is defined as that<br />

period of time where there is a stable near zero first derivative of the<br />

instantaneous phase difference between d( ϕ<br />

t<br />

− ϕ′<br />

t<br />

_/t ≈ 0. A high coherence<br />

value is related to extended periods of phase locking. A significant positive<br />

first derivative of the time series of coherence marks the onset of phase<br />

locking <strong>and</strong> a significant negative first derivative of the time series of<br />

coherence marks the onset of phase dispersion over an interval of time. The<br />

significance level can be determined by computing the means <strong>and</strong> st<strong>and</strong>ard<br />

deviations of the first derivative for each time series <strong>and</strong> then computing a Z<br />

u − x<br />

score for each time point with alpha at P < .05 or Z = where u = mean<br />

SD<br />

<strong>and</strong> x = the instantaneous first derivative at t <strong>and</strong> SD = st<strong>and</strong>ard deviation.<br />

For example, depending on the method of computation, values near zero st.<br />

dev. or < 1 st. dev may define the state of “Phase Locking”. Values > 2 st.<br />

dev. may define the state of “Phase Transition” or “Phase Reset” (the alpha<br />

threshold is a matter of observation <strong>and</strong> test).<br />

Figure ten illustrates the concept of phase reset. Coherence is a<br />

measure of phase consistency or phase clustering on the unit circle as<br />

measured by the length of the unit vector r. The illustration in figure 10<br />

shows that the resultant vector r 1 = r 2 <strong>and</strong> therefore coherence when<br />

averaged over time is constant even though there can be a shift in the phase

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