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The Safety and Tolerability of Atopaxar (E5555) in ... - summitMD.com

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LANCELOT-ACS<br />

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12.0%<br />

10.0%<br />

Incidence <strong>of</strong> CV death, MI, Stroke, or<br />

Recurrent ischemia<br />

10.8%<br />

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P trend = 0.26<br />

9.5%<br />

8.0%<br />

7.8%<br />

8.0%<br />

6.0%<br />

4.0%<br />

3.9%<br />

2.0%<br />

0.0%<br />

Placebo<br />

n=142<br />

Active <strong>com</strong>b<strong>in</strong>ed<br />

atopaxar<br />

n=461<br />

50mg QD 100mg QD 200mg QD<br />

n=156 n=157 n=148<br />

RR (95% CI) vs.<br />

placebo<br />

RR 1.04 (0.55-1.97)<br />

P = 0.93<br />

RR 0.50 (0.16-1.27)<br />

P = 0.18<br />

RR 1.40 (0.68-2.86)<br />

P = 0.37<br />

RR 1.22 (0.58-2.57<br />

P = 0.63

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