ANNUAL REVIEW master Final3a - St Vincent's University Hospital

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St. Vincent’s Healthcare Group Limited - Annual Review 2007 Education & Research Joesph Marry. A Case of Reversible Cortical Blindness. Irish Society of Medical Oncology Education Meeting, Dublin, Feb 2007. Joesph Marry: Assessing the effects of monoclonal antibody therapies and telomerase inhibition on proangiogenic growth factor secretions in individual human colorectal cancer explants. Irish Society of Gastroenterology Winter Meeting Plenary Session, Dublin, December 2007 and at the Irish Society of Medical Oncology Education Meeting, Dublin, December 2007 Alan Coss. Overexpression of topoisomerase II alpha in CRC is associated with resistance to etoposide and irinotecan. Irish Society of Gastroenterology Winter meeting, Dublin, November 2007 Alan Coss. Medical management of inflammatory bowel disease. School of Nursing, Midwifery & Health Systems, University College Dublin, January 2007. Students Graduated in 2007 Edward Fox, Ph.D. Thesis Title: Molecular analysis of colorectal cancer and its role in detecting familial cancer. Julie Gorman, MSc. Thesis title: The effect of telomerase inhibition in regulating treatment response in colorectal cancer cell lines. Current National & International Research Collaborators Prof. Peter Rabinovitch, University of Washington, Seattle, Prof. Larry Loeb, University of Washington, Seattle, Prof. Martin Tenniswood, Notre Dame, Indiana, Dr Oliver Zierau, Dresden, Dr. Cal Harley, Geron Co. Califormia, Dr. Walter Kloch, Glasgow, Dr Orla Howe, Dr. Fiona Lyng, DIT, Kevin Street, Dr. Cormac Taylor, Dr. Katrina Comerford, Amanda Mc Cann, Conway Institute, UCD, Prof. Kevin Malone, Dr. Douglas Veale, Dr. Ursula Fearon, St Vincents University Hospital, Dublin, Dr. Dermot Leahy, Conway Institute, UCD, Dr. Elizabeth Ryan and Prof. Cliona O’Farrelly, Trinity College Dublin, Prof. Alan Baird, Vet School, UCD, Dr. Paul Walsh, National Cancer Registry for Ireland, Cork. Our current translational research projects Role of genomic instability and hypoxia in governing response to therapies using in vitro and ex vivo explant models (Joe Marry & Miriam Tosetto) Role of oxidative stress and DNA damage in CRC (Juliette Sheridan). Molecular classification of familial colorectal cancer (Maciej Milewski &Dermot Leahy). Bystanders effects and tumour recurrence in colorectal cancer (Sheeona Gorman) Analysis of chromosomal instability patterns in non-metastatic and metastatic CRC using array comparative genomic hybridization, and validation of novel gene alterations using fluorescent in situ hybridisation (Alan Coss). Timing and rates of random nuclear and mitochondrial spontaneous mutations in colorectal cancer: implications for early detection and chemotherapy resistance (Edward Fox). Examination of prognostic gene signature in Stage II good and poor survivors (Dave Kevans). Cigarette smoking and genomic instability: factors controlling disease progression and treatment sensitivity in inflammatory bowel disease patients (Garret Cullen) Examination of Immune modulators involved in laproscopic and open colorectal cancer surgery (Chin Hong Lim) Return to Contents 50
St. Vincent’s Healthcare Group Limited - Annual Review 2007 Education & Research Breast Cancer Research Principal Investigator: Professor Joe Duffy Researchers: Patricia McGowan, Dr Aisling Pierce, Dr Eadaoin McKiernan, Dr Brid Ryan, Dr Neil O’Brien (currently visiting scientist in the lab of Drs Denis Slamon, University of California at Los Angeles) Collaborators (Local): Professor John Crown, Mr Enda McDermott, Mr Denis Evoy, Dr Liam Gallagher, Professor Steve Pennington, Professor F Martin (UCD), Dr Norma O’Donovan (DCU) Collaborators (International): Drs Denis Slamon/Gottfried Konecny, University of California at Los Angeles; Dr Stan Krajewski, Burnham Institute, La Jolla; Prof Fred Sweep, Nijmegen; Prof Nils Brunner, Copenhagen, Prof Manfred Schmitt, Munich. Research Focus The overall aim of the Breast Cancer Research Group is to develop new molecular markers to aid the early diagnosis of breast cancer, help with prognosis and predict likely response or resistance to specific therapies. Patricia McGowan is working on TACE (ADAM17), a multidomain protein possessing both a protease and an adhesion domain. Using both breast cancer cell lines and human tumors, Patricia has shown that TACE is involved in the progression of breast cancer. TACE is thus a potential new target for the treatment of breast cancer. During 2007, Patricia also carried out research on a new breast cancer biochip Aisling Pierce is involved in using proteomics and glycomics for the early detection of breast cancer. She is also investigating the potential role of the breast-specific gene, mammaglobin, in the formation of breast cancer. Eadaoin McKiernan is attempting to identify new markers for predicting the metastatic potential of newly diagnosed breast cancers. This work is being carried out as part of a HRB-funded Programme Grant Recognition of Work In 2007, the American Society of Clinical Oncology recommended clinical use of uPA for determining prognosis in patients with newly diagnosed breast cancer. The first demonstration of the clinical value and indeed much of the early work on this biomarker was carried out in the Education and Research by researchers working under the supervision of Professor Duffy. These researchers included Pauline O’Grady, David Reilly and Catherine Duggan Higher Degrees/Fellowships Patricia McGowan received her PhD in 2007 for her research on “ADAM17 in Breast Cancer”. During the year, Brid Ryan began a Health Research Board/National Cancer Institute (USA) Fellowship in Preventative Oncology. This Fellowship will allow Brid to work at the world famous National Cancer Institute in the US. Return to Contents 51
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Department of Cardiology The demand
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Papers Published & Accepted Ponikow
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Cancer remains a significant focus
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St. Vincent’s University Hospital
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ANNUAL REVIEW master Final3a - St Vincent's University Hospital

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