ANNUAL REVIEW master Final3a - St Vincent's University Hospital

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In collaboration with Prof. Kingston Mills, TCD; Dr Jean Fletcher, TCD 7. The effects of IFN-‚ on Toll-Like Receptor (TLR) induced cytokine production by dendritic cells IFNα‚ is currently the most commonly used immunomodulatory treatment for MS; however the mechanism by which it mediates these effects is still not well understood. Dendritic cells play a pivotal role in directing immune responses via their production of of cytokines, usually in response to infection via stimulation of TLRs. We are therefore investigating the ability of IFN-β to modulate the cytokine profile of dendritic cells stimulated with different TLR agonists. Treatment of DCs with IFN beta suppressed production of the pro-inflammatory cytokines IL-12p40 and IL-23, following TLR2 activation, but not in response to agonists for other TLRs. We are currently investigating whether this effect is due to induction of IL-10. These data suggest that IFN-beta may exert its protective effect in MS patients by modulating production of innate inflammatory cytokines that promote the induction of pathogenic autoreactive T cells In collaboration with Prof. Kingston Mills, TCD; Cheryl Sweeney TCD; Dr Jean Fletcher TCD 8. An examination of the response shift phenomenon in relation to quality of life assessment in Multiple Sclerosis. L. Costelloe, K.O’Rourke, C. McGuigan, C Walsh, N Tubridy, M Hutchinson ‘Response shift’ describes a change in the patient’s measure of self-evaluation in relation to a target construct (e.g. quality-of-life measures). It may be a source of bias in self-report studies. This paper describes the occurrence of a ‘response shift’ in patients with MS of varying severity. From this cohort we plan to re-assess a group of 100 patients with significant disability, observing for further evidence of the ‘response shift’ phenomenon, comparing clinical findings with patient perception of the impact of MS on their physical and psychological well-being (MSIS-29 scale). Meetings attended ABN London 2007 ECTRIMS – Prague, October 11th-14th 2007 AAN Boston 2007 Return to Contents 46
St. Vincent’s Healthcare Group Limited - Annual Review 2007 Education & Research Centre for Colorectal Disease Personnel: Consultant Gastroenterologist Diarmuid O’Donoghue (Director of Centre for Colorectal Disease) Consultant Surgeon John Hyland Des Winter Consultant Pathologists Kieran Sheahan Consultant Gastroenterologists Hugh Mulcahy Consultant Oncologist David Fennelly Senior Research Scientist Jacintha O’Sullivan Consultant Pathologist David Gibbons Consultant Radiation Oncologists John Armstrong Michael Moriarty Genetic Nurse Specialist Denise Keegan Cancer Nurse Co-ordinator Anne White Nurse Specialists Nikki Smith Grace McEvoy Senior Medical Scientists Robert Geragthy Research Nurse Blathnaid Nolan Senior Scientists Dermot Leahy Research Assistant Miriam Tosetto Postdoctoral Fellow (joint fellow with Rheumatology) Monica Biniecka Postdoctoral Fellow (NCI/HRB fellow) Edward Fox MD research fellow Alan Coss Dave Kevans Garret Cullen Joe Marry Ph.D students Sheeona Gorman Juliette Sheridan Maciej Milewski MSc. Students Julie Gorman MCh fellow Chin Hong Lim Changes to our research team in 2007: In 2007, Maciej Milewski joined our group as a Ph.D student and is analysing the molecular features associated with familial colorectal cancer. Maciej is funded by a HRB project grant. Monika Biniecka has embarked on postdoctoral studies in collaboration between our group and the Department of Rheumatology, St Vincents Hospital. Monika is investigating how genomic instability events may be altered in the hypoxic joint and how this in turn may control disease progression and treatment sensitivity in rheumatoid arthritis patients. Monika is funded for 3 years by a HRB Translational research grant (PI: D. Veale, co-applicants: J O’Sullivan, U Fearon and C Taylor). Also in 2007, Edward Fox a postdoctoral fellow was awarded a prestigious joint HRB/NCI grant to spend one year in the Joesph Gottesin laboratory in Seattle with Prof. Larry Loeb and the second year in St Vincents Hospital. Edward is currently in Seattle learning new technologies to assess the levels of random nuclear and mitochondrial mutations in adenoma and colorectal cancer tissue. These technologies will be translated back to our laboratory later this year. Return to Contents 47
Page 3 and 4: Review 2007 St. Vincent’s Healthc
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Page 7 and 8: Celebrations • There was a great
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Report from the Director of Nursing
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Hospital Hygiene Services St. Vince
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Department of Medical Oncology inco
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Department of Cardiology The demand
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Papers Published & Accepted Ponikow
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Department - Medicine Department of
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Department of Endocrinology & Diabe
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Lios Aoibhinn Cancer Support Centre
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Issues continuing to challenge the
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Service Developments Neurology in t
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Cancer remains a significant focus
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General Services necessitated in ex
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ICT Department Staffing In 2007 we
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St. Vincent’s University Hospital
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ANNUAL REVIEW master Final3a - St Vincent's University Hospital

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