ANNUAL REVIEW master Final3a - St Vincent's University Hospital
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ANNUAL REVIEW master Final3a - St Vincent's University Hospital

ANNUAL REVIEW master Final3a - St Vincent's University Hospital ANNUAL REVIEW master Final3a - St Vincent's University Hospital

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01.09.2014 Views

St. Vincent’s Healthcare Group Limited - Annual Review 2007 Department - Medical and Surgical Gastroenterology Research and Education The Centre for Colorectal Disease (CCD) is an umbrella for clinicians and scientists with an interest in Colorectal Cancer, Inflammatory Bowel Disease and Functional Bowel Disorders. The aims of the centre are the delivery of state of the art services for our patients, research into causes and treatment and the education of the public. However, the multidisciplinary team would be unable to function successfully without the aid of nursing co-ordinators and nurse specialists such as Anne White, Denise Keegan and Grace McEvoy who lead patients through the varied and complex pathways of diagnosis, treatment and postoperative stoma care in a way that appears seamless. Joanne McCarthy has joined the team as a nurse specialist. The Excelicare database system is now the backbone of the weekly Colorectal Cancer audit organised by Anne White, Marian Ward, Stewart Thompson and Ken Curran. The research arm of the Centre for Colorectal Disease continues to flourish under the guidance of Dr Jacintha O’Sullivan, Senior Research Scientist. The main research goals of the Centre for Colorectal Disease are to achieve a more complete understanding of which biological factors that drive colorectal cancer and to determine if different biological markers can distinguish people at high risk and elucidate which subset of patients will response to particular treatment regimes. The goal of these translational research projects based on unique and exciting explant work is to determine which cancers require additional treatment and what therapies might be most effective. Such work has the potential for huge financial savings in the management of Colorectal Cancer. The large and detailed databases for patients with Bowel Cancer and Inflammatory Bowel Disease enable many of the projects to be achieved. The unit has very productive collaborations with both national and international institutions. Along with our colleagues in the Mater Misericordiae University Hospital and University College Dublinunder the umbrella of Dublin Academic Health Care- the Centre has received recommendation for a 5 million euro grant that, at the time of writing, awaits funding confirmation from the HRB. This grant is centred on the management of bowel cancer in the elderly. Professors O’Donoghue and O’Connell represent the Hospital on the National Colorectal Cancer Screening Committee. Our Annual International Colorectal Meeting in the Education and Research Centre each September continues to draw large numbers of attendees and is an ideal platform to display the various strengths and activities of the unit. We wish to record our thanks to the many individuals and groups who raise funds for our research. In particular we would like to acknowledge foundations to the memory of Ellie Brady, Susie Byrne and Darragh Gibbons. Papers Selected papers : (21 in total 2007) O’Sullivan J, Sheridan J, Mulcahy H, Tenniswood M and Morrissey C. The effect of green tea on oxidative damage and tumour formation in Lobound-Wistar rats. (accepted Dec 2007, currently in press). Return to Contents 252

St. Vincent’s Healthcare Group Limited - Annual Review 2007 Department - Medical and Surgical Gastroenterology Cullen G, O'Toole A, Keegan D, Sheahan K, Hyland JM, O'Donoghue DP. Long-term clinical results of ileocecal resection for Crohn's disease. Inflamm Bowel Dis. 2007 Nov;13(11):1369-73. Hanly AM, Winter DC. The role of thrombomodulin in malignancy. Semin Thromb Hemost. 2007 Oct;33(7):673-9. Review. PMID: 18000794 [PubMed - indexed for MEDLINE] Feighery LM, Cochrane SW, Quinn T, Baird AW, O'Toole D, Owens SE, O'Donoghue DP, Mrsny RJ, Brayden DJ. Myosin Light Chain Kinase Inhibition: Correction of Increased Intestinal Epithelial Permeability In Vitro. Pharm Res. 2007 Dec 27; [Epub ahead of print] PMID: 18163202 [PubMed - as supplied by publisher] Burke JP, Mulsow JJ, O'Keane C, Docherty NG, Watson RW, O'Connell PR. Fibrogenesis in Crohn's disease. Am J Gastroenterol. 2007 Feb;102(2):439-48. Epub 2006 Dec 11. Review. PMID: 17156147 [PubMed - indexed for MEDLINE] McGuire BB, Brannigan AE, O'Connell PR. Ileal pouch-anal anastomosis. Br J Surg. 2007 Jul;94(7):812-23. Review. PMID: 17571291 [PubMed - indexed for MEDLINE] Book Chapter Shields C, O’Connell PR ELECTROCAUTERY in Trimbos JB, Trimbos-Kemper TC eds BASICS OF SURGERY:tools, techniques, attitude and expertise. 2007 Elsevier, Maarssen, 67-77 Presentations in 2007 16 abstracts were presented during 2007 at various international and national meetings. These included the American Association for Cancer Research, American Gastroenterology Association, Irish Association for Cancer Research and the Irish Society of Gastroenterology. Return to Contents 253

<strong>St</strong>. Vincent’s Healthcare Group Limited - Annual Review 2007<br />

Department - Medical and Surgical Gastroenterology<br />

Cullen G, O'Toole A, Keegan D, Sheahan K, Hyland JM, O'Donoghue DP. Long-term clinical results of<br />

ileocecal resection for Crohn's disease. Inflamm Bowel Dis. 2007 Nov;13(11):1369-73.<br />

Hanly AM, Winter DC.<br />

The role of thrombomodulin in malignancy.<br />

Semin Thromb Hemost. 2007 Oct;33(7):673-9. Review.<br />

PMID: 18000794 [PubMed - indexed for MEDLINE]<br />

Feighery LM, Cochrane SW, Quinn T, Baird AW, O'Toole D, Owens SE, O'Donoghue DP, Mrsny RJ, Brayden DJ.<br />

Myosin Light Chain Kinase Inhibition: Correction of Increased Intestinal Epithelial Permeability In Vitro.<br />

Pharm Res. 2007 Dec 27; [Epub ahead of print]<br />

PMID: 18163202 [PubMed - as supplied by publisher]<br />

Burke JP, Mulsow JJ, O'Keane C, Docherty NG, Watson RW, O'Connell PR.<br />

Fibrogenesis in Crohn's disease.<br />

Am J Gastroenterol. 2007 Feb;102(2):439-48. Epub 2006 Dec 11. Review.<br />

PMID: 17156147 [PubMed - indexed for MEDLINE]<br />

McGuire BB, Brannigan AE, O'Connell PR.<br />

Ileal pouch-anal anastomosis.<br />

Br J Surg. 2007 Jul;94(7):812-23. Review.<br />

PMID: 17571291 [PubMed - indexed for MEDLINE]<br />

Book Chapter<br />

Shields C, O’Connell PR<br />

ELECTROCAUTERY in Trimbos JB, Trimbos-Kemper TC eds BASICS OF SURGERY:tools, techniques,<br />

attitude and expertise. 2007 Elsevier, Maarssen, 67-77<br />

Presentations in 2007<br />

16 abstracts were presented during 2007 at various international and national meetings. These included the<br />

American Association for Cancer Research, American Gastroenterology Association, Irish Association for<br />

Cancer Research and the Irish Society of Gastroenterology.<br />

Return to Contents<br />

253

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