ANNUAL REVIEW master Final3a - St Vincent's University Hospital

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St. Vincent’s Healthcare Group Limited - Annual Review 2007 Department - Rheumatology Hypoxia Chambers and Luminometer HRB Equipment Grant Award €75k (PI - Ursula Fearon) In vivo Hypoxic probes and monitor. UCD Seed Funding €20k (PI - Ursula Fearon) Proof of concept studies of novel biopharmaceutical and small molecular weight inhibitors using whole tissue explant cultures. GlaxoSmithKline €680k (PI - Douglas Veale) Cytokine Regulation in Synovial explant cultures and pre/post biologic therapy. Wyeth Pharmaceuticals €350k (PI - Douglas Veale) Publications: Fearon U, Veale DJ. Angiogenesis in arthritis: methodological and analytical details. Methods Mol Med. 2007;135:343-57. PMID: 17951670 [PubMed - indexed for MEDLINE] Greetham D, Ellis CD, Mewar D, Fearon U, an Ultaigh SN, Veale DJ, Guesdon F, Wilson AG. Functional characterization of NF-kappaB inhibitor-like protein 1 (NFkappaBIL1), a candidate susceptibility gene for rheumatoid arthritis. Hum Mol Genet. 2007 Dec 15;16(24):3027-36. Epub 2007 Sep 12. PMID: 17855452 [PubMed - in process] Mullan RH, Matthews C, Bresnihan B, FitzGerald O, King L, Poole AR, Fearon U, Veale DJ. Early changes in serum type II collagen biomarkers predict radiographic progression at one year in inflammatory arthritis patients after biologic therapy. Arthritis Rheum. 2007 Sep;56(9):2919-28. PMID: 17763421 [PubMed - indexed for MEDLINE] Gladman DD, Inman RD, Cook RJ, Maksymowych WP, Braun J, Davis JC, Landewé RB, Mease P, Brandt J, Vargas RB, Chandran V, Helliwell P, Kavanaugh A, O'Shea FD, Khan MA, Pipitone N, Rahman P, Reveille JD, Stone MA, Taylor W, Veale DJ, van der Heijde D. International spondyloarthritis interobserver reliability exercise--the INSPIRE study: II. Assessment of peripheral joints, enthesitis, and dactylitis. J Rheumatol. 2007 Aug;34(8):1740-5. PMID: 17659754 [PubMed - indexed for MEDLINE] Burgoyne CH, Field SL, Brown AK, Hensor EM, English A, Bingham SL, Verburg R, Fearon U, Lawson CA, Hamlin JP, Straszynski L, Veale D, Conaghan P, Hull MA, van Laar JM, Tennant A, Emery P, Isaacs JD, Ponchel F. Abnormal T-cell differentiation persists in rheumatoid arthritis patients in clinical remission and predicts relapse. Ann Rheum Dis. 2007 Jul 20; [Epub ahead of print] PMID: 17644540 [PubMed - as supplied by publisher] Walsh CA, Minnock P, Slattery C, Kennedy N, Pang F, Veale DJ, Bresnihan B, FitzGerald O. Quality of life and economic impact of switching from established infliximab therapy to adalimumab in patients with rheumatoid arthritis. Rheumatology (Oxford). 2007 Jul;46(7):1148-52. Epub 2007 May 3. PMID: 17478471 [PubMed - indexed for MEDLINE] Return to Contents 216
St. Vincent’s Healthcare Group Limited - Annual Review 2007 Department - Rheumatology Rooney T, Bresnihan B, Andersson U, Gogarty M, Kraan M, Schumacher HR, Ulfgren AK, Veale DJ, Youssef PP, Tak PP. Microscopic measurement of inflammation in synovial tissue: inter-observer agreement for manual quantitative, semiquantitative and computerised digital image analysis. Ann Rheum Dis. 2007 Dec;66(12):1656-60. Epub 2007 Jun 29. PMID: 17604286 [PubMed - indexed for MEDLINE] Bresnihan B, Gerlag DM, Rooney T, Smeets TJ, Wijbrandts CA, Boyle D, Fitzgerald O, Kirkham BW, McInnes IB, Smith M, Ulfgren AK, Veale DJ, Tak PP. Synovial macrophages as a biomarker of response to therapeutic intervention in rheumatoid arthritis: standardization and consistency across centers. J Rheumatol. 2007 Mar;34(3):620-2. PMID: 17343309 [PubMed - indexed for MEDLINE] Denton CP, Merkel PA, Furst DE, Khanna D, Emery P, Hsu VM, Silliman N, Streisand J, Powell J, Akesson A, Coppock J, Hoogen F, Herrick A, Mayes MD, Veale D, Haas J, Ledbetter S, Korn JH, Black CM, Seibold JR; Cat-192 Study Group; Scleroderma Clinical Trials Consortium. Recombinant human antitransforming growth factor beta1 antibody therapy in systemic sclerosis: a multicenter, randomized, placebo-controlled phase I/II trial of CAT-192. Arthritis Rheum. 2007 Jan;56(1):323-33. PMID: 17195236 [PubMed - indexed for MEDLINE] Marzo-Ortega H, McGonagle D, Rhodes LA, Tan AL, Conaghan PG, O'Connor P, Tanner SF, Fraser A, Veale D, Emery P. Efficacy of infliximab on MRI-determined bone oedema in psoriatic arthritis. Ann Rheum Dis. 2007 Jun;66(6):778-81. Epub 2006 Dec 21. PMID: 17185324 [PubMed - indexed for MEDLINE] Ralph JA, Zocco D, Bresnihan B, Fitzgerald O, McEvoy AN, Murphy EP. A role for type 1alpha corticotropin-releasing hormone receptors in mediating local changes in chronically inflamed tissue.Am J Pathol. 2007 Mar;170(3):1121-33. PMID: 17322394 [PubMed - indexed for MEDLINE] Gogarty M, Fitzgerald O. Immunohistochemistry of the inflamed synovium. Methods Mol Med. 2007;135:47-63. PMID: 17951651 [PubMed - indexed for MEDLINE] Patterson AM, Cartwright A, David G, Fitzgerald O, Bresnihan B, Ashton BA, Middleton JF. Differential expression of syndecans and glypicans in chronically inflamed synovium. Ann Rheum Dis. 2007 Jul 13; [Epub ahead of print] PMID: 17545191 [PubMed - as supplied by publisher] Gladman DD, Mease PJ, Strand V, Healy P, Helliwell PS, Fitzgerald O, Gottlieb AB, Krueger GG, Nash P, Ritchlin CT, Taylor W, Adebajo A, Braun J, Cauli A, Carneiro S, Choy E, Dijkmans B, Espinoza L, van der Heijde D, Husni E, Lubrano E, McGonagle D, Qureshi A, Soriano ER, Zochling J. Consensus on a core set of domains for psoriatic arthritis. J Rheumatol. 2007 May;34(5):1167-70. PMID: 17477480 [PubMed - indexed for MEDLINE] Gladman DD, Mease PJ, Healy P, Helliwell PS, Fitzgerald O, Cauli A, Lubrano E, Krueger GG, van der Heijde D, Veale DJ, Kavanaugh A, Nash P, Ritchlin C, Taylor W, Strand V. Outcome measures in psoriatic arthritis. J Rheumatol. 2007 May;34(5):1159-66. PMID: 17477479 [PubMed - indexed for MEDLINE] Return to Contents 217
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Review 2007 St. Vincent’s Healthc
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St. Vincent’s Healthcare Group Li
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Celebrations • There was a great
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Research Studies Total Research Stu
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14 Research
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The bioinformatics group moved with
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In collaboration with Prof. Kingsto
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Education & Research Poster Present
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Education & Research Pharmaceutical
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74 Quality
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St. Vincent's Private Hospital Cons
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Hospital Hygiene Services St. Vince
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General Services The HACCP system i
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General Services necessitated in ex
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ICT Department Staffing In 2007 we
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St. Vincent’s University Hospital
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