Anaesthesia, Intensive Care and Pain Medicine - St Vincent's ...
Anaesthesia, Intensive Care and Pain Medicine - St Vincent's ...
Anaesthesia, Intensive Care and Pain Medicine - St Vincent's ...
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<strong>St</strong>.Vincent’s Healthcare Group<br />
Research<br />
Publications<br />
136<br />
Consultant Medical <strong>and</strong> Surgical staff<br />
Medical Gastroenterology<br />
Professor DP O’Donoghue<br />
Dr HE Mulcahy<br />
Colorectal Surgery<br />
GI Pathology<br />
Mr J Hyl<strong>and</strong><br />
Dr K Sheahan<br />
GI Diagnostic Imaging Dr C Collins, Dr R Gibney, Dr D Malone<br />
Medical Oncology<br />
Radiation Oncology<br />
Dr D Fennelly<br />
Dr M Moriarty, Professor J Armstrong<br />
Non-Consultant Medical <strong>and</strong> Surgical staff<br />
Specialist Registrars<br />
Dr D O’Donovan,Mr D Winter<br />
Clinical Nurse Managers<br />
<strong>St</strong>.Teresa’s ward Ms A Smyth,Ms G O’Neill<br />
<strong>St</strong>. Patrick’s ward Ms A Kiely, Ms B Nolan<br />
Endoscopy Unit Mr R Marshall, Ms G Hickey<br />
Nurse Specialists<br />
Colorectal Nurse Specialists<br />
Ms G McEvoy, Ms N Smith<br />
Colorectal Cancer Nurse Co-Ordinator<br />
Ms A White<br />
Research <strong>St</strong>aff<br />
Senior Research Scientist<br />
Dr J O’Sullivan<br />
Senior Biochemist <strong>and</strong> Honorary Lecturer<br />
Dr D Leahy<br />
Research Fellows<br />
Research Nurse<br />
PhD student<br />
MSc <strong>St</strong>udent<br />
Clinical Scientist<br />
Dr S Cochrane, Dr AM Lennon,<br />
Mr R Ryan<br />
Ms D Keegan<br />
Mr E Fox<br />
Dr M Bakhist<br />
Senior Medical Scientist<br />
Mr R Geraghty<br />
Dieticians<br />
Medical Gastroenterology<br />
Surgical Gastroenterology<br />
Ms M Doyle<br />
Ms C Lamont<br />
Medical <strong>and</strong> Surg i c a l<br />
G a s t ro e n t e rology<br />
i n c o r p o r a t i n g<br />
C e n t re for Colorectal Disease<br />
Departmental Review<br />
Medical <strong>and</strong> Surgical Gastroenterology continues to play a<br />
major role in the activities of <strong>St</strong> Vincent’s Healthcare Group.<br />
Close to one third of all hospital admissions fit into the<br />
category of acute or chronic gastroenterology <strong>and</strong> it is<br />
appropriate that the Medical <strong>and</strong> Surgical units work so closely<br />
together. For some years now Medical <strong>and</strong> Surgical<br />
Gastroenterology have run a combined colorectal clinic,<br />
probably unique in this isl<strong>and</strong>.This clinic, plus weekly Radiology<br />
<strong>and</strong> Pathology conferences run with our Diagnostic Imaging <strong>and</strong><br />
Pathology colleagues,allow for best practice in patient care <strong>and</strong><br />
provide an excellent source of teaching for NCHDs.Further<br />
combined meetings include a monthly Audit of Colorectal<br />
Cancer <strong>and</strong> monthly research symposia in Inflammatory Bowel<br />
disease <strong>and</strong> Cancer.We wish to acknowledge the close clinical<br />
<strong>and</strong> scientific support we receive from our colleagues in<br />
Medical <strong>and</strong> Surgical Oncology <strong>and</strong> Palliative <strong>Care</strong>.We also wish<br />
to put on record our thanks to our nursing colleagues on<br />
<strong>St</strong>.Teresa’s <strong>and</strong> <strong>St</strong>. Patrick’s wards who manage our<br />
gastroenterology patients despite major involvement in general<br />
Medical <strong>and</strong> Surgical call.<br />
2003 saw the arrival of laparoscopically assisted surgery for the<br />
management of patients with Colorectal diseases.This technique<br />
established <strong>and</strong> audited by Mr. John Hyl<strong>and</strong> <strong>and</strong> his team is a<br />
major advance in the management of patients with colorectal<br />
disorders<br />
2003 has been a time of great change in <strong>St</strong> Vincent’s University<br />
Hospital.The new building that commenced in 2002 has rapidly<br />
taken shape <strong>and</strong> much of the efforts of the staff from the<br />
Centre for Colorectal Disease have been directed towards the<br />
future to ensure a successful transition to the new building.The<br />
arrival of Mr. Richard Marshall to the post of CNM2 in the<br />
endoscopy unit has been particularly opportune. His<br />
management skills have already borne fruit within the existing<br />
endoscopy unit <strong>and</strong> we look forward to his leading us into the<br />
specially designed 3- roomed Endoscopy Unit in the new<br />
building.As usual, Ms Nuala Donnelly <strong>and</strong> staff in <strong>St</strong>. Mark’s Day<br />
ward continue to appear to produce beds out of nothing for<br />
our patients <strong>and</strong> the exp<strong>and</strong>ed medical <strong>and</strong> surgical day care<br />
unit may provide some relief to the ever-present problem of<br />
finding day care beds.<br />
As the physical structure of the hospital is changing,so is the<br />
structure <strong>and</strong> nature of the clinical <strong>and</strong> basic research that is<br />
being conducted by the Centre for Colorectal Disease.The<br />
most significant event for the Centre in 2003 was the<br />
appointment of Dr Jacintha O’Sullivan as Senior Research<br />
Scientist.Dr O’Sullivan,a UCD graduate, spent a number of<br />
years in prestigious US institutions before returning in May 2003<br />
to lead our ambitious clinical <strong>and</strong> basic science research<br />
programme. Her special interests include the relationship<br />
between inflammation <strong>and</strong> cancer <strong>and</strong> we have already seen<br />
the benefits of her knowledge <strong>and</strong> enthusiasm in increased<br />
grant support, increased clinical <strong>and</strong> basic scientific staff <strong>and</strong><br />
increased output of quality research. D r. O ’ S u l l i v a n ’s org a n i s a t i o n a l<br />
skills have also allowed us to commence a number of complex,<br />
though interr e l a t e d ,colorectal cancer projects in areas such as<br />
pre-neoplastic marke rs of colorectal disease, biomarkers in early<br />
cancer <strong>and</strong> factors associated with disease in young adult<br />
patients.These projects will continue to develop over the next<br />
three years <strong>and</strong> will lead to MD Theses in each case.<br />
Dr Hugh Mulcahy received a three year grant from Cancer<br />
Research Irel<strong>and</strong> to investigate "Protease profiling in early<br />
colorectal cancer: Its role in anatomical <strong>and</strong> clinical progression".<br />
Mr Shane Sullivan <strong>and</strong> Ms Julie Gorman have been appointed as<br />
medical scientists to work on this programme.<br />
Ronan Ryan continues his work identifying immunohistochemical<br />
markers associated with response to chemoradiotherapy<br />
in rectal cancer, while Anne Marie Lennon,Eddie Fox<br />
<strong>and</strong> Denise Keegan are studying the genetic make up of<br />
patients with familial Colorectal Cancer.<br />
The unit presented work at a number of National <strong>and</strong><br />
International meetings including the AGA,USCAP <strong>and</strong> the ISG.<br />
Education<br />
The Tenth International Colorectal Meeting was held in the<br />
Education <strong>and</strong> Research Centre in September. Professor Bruce<br />
Minsky from New York delivered the <strong>St</strong>ate of the Art Lecture<br />
Grace McEvoy again organised a very successful Annual <strong>St</strong>udy<br />
Day for nurses in April.<br />
The centre continued with its policy of giving lectures to the<br />
general public throughout the year.<br />
Hugh Mulcahy continued with his involvement in the Beaumont<br />
Hospital Tips <strong>and</strong> Tricks Courses held in March <strong>and</strong> September.<br />
Microscopic Colitis: Collagenous <strong>and</strong> Lymphocytic colitis.<br />
O’Donoghue DP <strong>and</strong> Sheahan K in Inflammatory Bowel Disease<br />
from Bench to Bedside. 2nd Edition. Chapter 43.791-798.Eds.<br />
Targan S.,Shanahan F. <strong>and</strong> Karp L.Kluwer Academic Publishers.<br />
2003<br />
Pe ritoneal involvement in <strong>St</strong>age II Colon Cancer. Lennon A M ,M u l c a hy<br />
HE,Hyl<strong>and</strong> JMP, Lowry C,White A,Fennelly D, Murphy JJ,<br />
O’Donoghue DP, & Sheahan K.Am J Clin Path 2003 119:108-113.<br />
Prognostic relevance of Fas (APO-1/CD95) lig<strong>and</strong> in human<br />
colorectal cancer. Sheehan KM,O'Donovan DG,Fitzmaurice G,<br />
O'Grady A,O'Donoghue DP, Sheahan K,Byrne MF, Conroy RM,<br />
Kay EW, Murray FE.Eur J Gastroenterol Hepatol 2003<br />
Apr;15(4):375-80.<br />
Neuroendocrine-1 Receptor (NK-1R) expression is induced in<br />
Human Colonic Epithelial cells by pro-inflammatory cytokines <strong>and</strong><br />
mediates proliferation in response to Substance P. Goode T,<br />
O’Connor T, Hopkins A,Moriarty D, O’Sullivan G,Collins JK,<br />
O’Donoghue DP, Baird AW, O’Connell J <strong>and</strong> Shanahan F. (2003).<br />
Journal of Cellular Physiology. 197;30-41.<br />
Association of NOD2 with Crohn's Disease in a homogenous Irish<br />
population. Bairead E,Harmon DL, Curtis AM,KellyY, Leary C,<br />
Gardner M,Leahy DT,Vaughan P, Keegan D, Morain C,<br />
O’Donoghue D, Shanahan F, Parfrey NA <strong>and</strong> Quane KA.<br />
(2003) European Journal of Human Genetics.(11) 237-244.<br />
Leahy DT, Lennon AM, Fox EJ, Mulcahy HE,O’Donoghue DP,<br />
Sheahan K, Parfrey NA.Detection <strong>and</strong> clinicopathological<br />
significance of BAT-26 microsatellite instability in colorectal cancer.<br />
Proc.Amer. Assoc. Cancer Res.(1st ed.),44: 2505,2003.<br />
Grants<br />
Protease profiling in early Colorectal Cancer <strong>and</strong> its association<br />
with chromosomal abnormalities,anatomical stage <strong>and</strong> clinical<br />
progression. €135,000 (collaboration with Dr. Hugh<br />
Mulcahy & Dr. Kieran Sheahan) Cancer Research<br />
Irel<strong>and</strong> 2003-2006.<br />
Finally the Centre would like to<br />
acknowledge the generous donations<br />
for research <strong>and</strong> education from<br />
Mr. Pat Douglas <strong>and</strong> the<br />
family <strong>and</strong> friends of the<br />
late Elie Brady.<br />
137