Typhoid fever - SRM University
Typhoid fever - SRM University
Typhoid fever - SRM University
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Antibiotic resistance<br />
• MDR is mediated by plasmid The genes for antibiotic resistance in S<br />
typhi and S paratyphi are acquired into a region called an integron from<br />
Escherichia coli and other gram-negative bacteria via plasmids.<br />
• Quinolone resistance is frequently mediated by single point mutations in the<br />
quinolone-resistance–determining region of the gyrA gene.<br />
• Nalidixic acid resistant: MIC of fluoroquinolones for these strains was 10<br />
times that for fully susceptible strains.
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