Typhoid fever - SRM University
Typhoid fever - SRM University
Typhoid fever - SRM University
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Chloramphenicol<br />
• Binds to 50S bacterial-ribosomal subunits and inhibits bacterial growth<br />
by inhibiting protein synthesis.<br />
• The recommended dosage is 50 - 75 mg per kg per day for 14 days<br />
divided into four doses per day, or for at least five to seven days after<br />
defervescence.<br />
• Oral administration gives slightly greater bio availability than<br />
intramuscular (i.m.) or intravenous (i.v.) administration of the succinate<br />
salt.<br />
• The disadvantages of using chloramphenicol include a relatively high<br />
rate of relapse (57%), long treatment courses (14 days) and the frequent<br />
development of a carrier state in adults.
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