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Volume 25 Number 12 SPECTROSCOPY CORPORATE CAPABILITIES ISSUE December 2010 

December 2010 Volume 25 Number 12 

www.spectroscopyonline.com 

C 2011 Corporate 

Capabilities 

I a Data t Integrity and the 

E 

Human Element 

E I 

2010 Editorial Index 

Application Notes ♦ See page 86

Raman power 

On the frontiers of research, Raman gains popularity with its outstanding power 

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© 2010 Thermo Fisher Scientific Inc. All rights reserved. 

DXR Raman Microscope 

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www.piketech.com 

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te 

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6 Spectroscopy 25(12) December 2010 

® 

CONTENTS 


volume 25 number 12 

december 2010 

December 2010 

Volume 25 Number 12 

Columns 

THE BASELINE 12 

Neutron Spectroscopy 

David Ball discusses neutron sources and introduces the two types of neutron scattering: 

elastic and inelastic. 

David W. Ball 

FOCUS ON QUALITY 15 

Fat Finger, Falsification, or Fraud? 

Where is the dividing line between a simple mistake and falsification? 

R.D. McDowall 

Cover image courtesy of 

Getty Images. 

Articles 

Spectroscopy Market: Weathering the Storm and 19 

on the Path to Recovery 

The author discusses current trends in the spectroscopy market. 

Sivakumar Narayanaswamy 

2010 Editorial Index 22 

Spectroscopy presents its annual index of authors and articles. 

ON THE WEB 

WEB SEMINARS 

New seminars now available on demand 

at www.spectroscopyonline.com: 

Changing Everything You Know About 

Liquids Analysis by FTIR 

Investigating Fluorescence Lifetime 

Spectroscopy and Imaging 

The Easiest and Most Cost-efficient 

Way to Determine Elements in 

Environmental Matrices by ICP-MS 

According to Your Regulations 

Increase LC/MS Throughput and 

Improve ROI for Biological Samples 

SPECTROSCOPY WAVELENGTH 

Subscribe to our monthly newsletter, which 

features new tools, applications, feature 

articles, and other industry developments. 

SPECTROSCOPYONLINE.COM 

The full spectrum of technical, applicationsoriented 

information about spectroscopy. 

Join the 

Spectroscopy Group 

on LinkedIn 

Application Notes 

Portable Transmission FTIR Analysis of Volatile Samples 86 

Using the DialPath Liquid Cell 

Frank Higgins, A2 Technologies 

Long-Wavelength Dispersive 1064nm Raman: Non-Invasive 88 

Cancer Tissue Diagnostics 

BaySpec, Inc. 

Determination of Low Concentration Methanol in Alcohol 89 

by an Affordable High Sensitivity Raman Instrument 

Duyen Nguyen and Eric Wu, Enwave Optronics, Inc. 

High-Resolution NIR Analysis 90 

R. Morris, Ocean Optics, Inc. 

DEPARTMENTS 

From the Editor . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10 

News Spectrum . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 

Corporate Capabilities . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .32 

Spectroscopy (ISSN 0887-6703 [print], ISSN 1939-1900 [digital]) is published monthly by Advanstar Communications, Inc., 

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December 2010 Volume 25 Number 12 

2011 Corporate Capabilities 

32 A2 Technologies 

62 Nippon Instruments North 

34 ABB Analytical Measurement 

36 Amptek, Inc. 

38 Applied Photophysics 

40 Avantes, Inc. 

41 B&W Tek, Inc. 

42 BaySpec, Inc. 

43 Bruker Corporation 

44 CVI Melles Griot 

45 Energetiq Technology, Inc. 

46 EDAX, Inc. 

48 Environmental Express 

49 Enwave Optronics, Inc. 

51 Harrick Scientific Products, Inc. 

52 Hellma USA, Inc. 

53 HORIBA Scientific 

54 International Centre for Diffraction 

Data (ICDD) 

55 Inorganic Ventures 

56 Innovative Photonic Solutions 

58 Iridian Spectral Technologies 

59 Newport Corporation 

60 Moxtek, Inc. 

America 

63 OI Analytical 

64 Ocean Optics, Inc. 

66 OptiGrate Corp. 

67 Optometrics Corporation 

68 PerkinElmer, Inc. 

70 Pair Technologies, LLC 

50 Parker Hannifin Corporation 

71 Photon etc. 

72 PHOTONIS USA 

73 PIKE Technologies 

74 Polymicro Technologies, A 

subsidiary of Molex Incorporated 

75 Specac, Inc. 

91 Spectroscopy 

76 Shimadzu Scientific Instruments 

78 SPEX CertiPrep 

80 Spellman High Voltage Electronics 

81 Teledyne Leeman Labs 

82 Thermo Fisher Scientific 

84 WITec GmbH 

85 XOS

www.spectroscopyonline.com December 2010 Spectroscopy 25(12) 9 

Editorial Advisory Board 

Ramon M. Barnes University of Massachusetts 

Paul N. Bourassa Lifeblood 

Chris W. Brown University of Rhode Island 

Kenneth L. Busch Wyvern Associates 

Ashok L. Cholli University of Massachusetts at Lowell 

David M. Coleman Wayne State University 

Patricia B. Coleman Ford Motor Company 

Bruce Hudson Syracuse University 

Kathryn S. Kalasinsky Armed Forces Institute of Pathology 

David Lankin University of Illinois at Chicago, College of Pharmacy 

Barbara S. Larsen DuPont Central Research and Development 

Ian R. Lewis Kaiser Optical Systems 

Jeffrey Hirsch Thermo Fisher Scientific 

Howard Mark Mark Electronics 

R.D. McDowall McDowall Consulting 

Linda Baine McGown Rensselaer Polytechnic Institute 

Robert G. Messerschmidt Rare Light, Inc. 

Nancy Miller-Ihli M–I Research 

Francis M. Mirabella Jr. Equistar Technology Center 

John Monti Shimadzu Scientific Instruments 

Thomas M. Niemczyk University of New Mexico 

Anthony J. Nip CambridgeSoft Corp. 

John W. Olesik The Ohio State University 

Richard J. Saykally University of California, Berkeley 

Basil I. Swanson Los Alamos National Laboratory 

Jerome Workman Jr. Consultant 

Contributing Editors: 

Fran Adar Horiba Jobin Yvon 

David W. Ball Cleveland State University 

Kenneth L. Busch Wyvern Associates 

John Coates Coates Consulting 

Howard Mark Mark Electronics 

Volker Thomsen Consultant 

Jerome Workman Jr. Consultant 

Process Analysis Advisory Panel: 

James M. Brown Exxon Research and Engineering Company 

Bruce Buchanan Sensors-2-Information 

Lloyd W. Burgess CPAC, University of Washington 

James Rydzak Glaxo SmithKline 

Robert E. Sherman CIRCOR Instrumentation Technologies 

John Steichen DuPont Central Research and Development 

D. Warren Vidrine Vidrine Consulting 

European Regional Editors: 

John M. Chalmers VSConsulting, United Kingdom 

David A.C. Compton Industrial Chemicals Ltd. 

Spectroscopy’s Editorial Advisory Board is a group of distinguished individuals 

assembled to help the publication fulfill its editorial mission to promote the effective 

use of spectroscopic technology as a practical research and measurement tool. 

With recognized expertise in a wide range of technique and application areas, board 

members perform a range of functions, such as reviewing manuscripts, suggesting 

authors and topics for coverage, and providing the editor with general direction and 

feedback. We are indebted to these scientists for their contributions to the publication 

and to the spectroscopy community as a whole.



From the Editor 

A New Adventure 

Sometimes, even when you enjoy your current work, embarking on a new adventure is just 

the thing. That is exactly the position I find myself in, as the new editorial director of 

Advanstar Communications’ Analytical Science group, which includes Spectrocopy and 

LCGC North America. 

I have spent the last five years as the editor in chief of a sister publication, BioPharm 

International, focused on biopharmaceutical process development and manufacturing. It was a 

wonderful place to be, because the field is fascinating and full of passionate people. Yet when 

presented with the opportunity to shift gears and join Spectroscopy and LCGC, I could not resist. 

Although only officially in the new job for 10 days now, I know already it was a good choice. 

Following meetings and phone calls with contributors and members of our editorial advisory 

board, as well as two days at the Eastern Analytical Symposium, it is clear to me that the fields 

of spectroscopy and chromatography, just like bioprocessing, are really interesting and full of 

great, passionate people. Who could ask for anything more? 

Well, I could. The thing I will ask for is your input. 

The questions I have been addressing with my editorial board are centered on providing you 

with the information you need. We are discussing the emerging trends and applications you 

should know about, the technological advances that may facilitate your work, and which leading 

researchers we want to invite to publish in our journals and speak in our educational web 

seminars. Keeping you abreast of the leading edge of spectroscopy is our job, and quite an 

enjoyable one at that. At the same time, no one knows better than you what challenges you face 

in the laboratory on a daily basis. Which measurements continue to present problems for you? 

Are you running into difficulty with a certain application or technique? Not sure what conditions 

are ideal for a given analysis? Let us know. 

In addition, the transition to a new editor is a perfect time to evaluate not just what 

leading-edge and ongoing topics we want to bring you, but also how well we are providing that 

information, through the print and digital editions of the journal, our educational web seminars, 

and our newsletters. Are there ways you feel we can do this better? Do you have new ideas we 

should consider? On the other hand, are there aspects of the magazine, our seminars, or any of our 

other digital offerings that you don’t want us to change at all? I encourage all of you to communicate 

with us about your interests, concerns, and ideas. Our purpose is to serve you, so we welcome 

any thoughts you have on how we can do that better. 

Laura Bush is the editorial director of LCGC 

North America and Spectroscopy, 

lbush@advanstar.com.


News Spectrum 

Research 

Scientists from the Rollins School of Public 

Health at Emory University (Atlanta, Georgia) have 

recently developed a new statistical method for liquid 

chromatography–mass spectrometry (LC–MS) analysis. 

Tianwei Yu and Hesen Peng arrived at this new 

estimation model by carrying out a series of 

simulations, along with tests on a number of various 

real-world samples. 

In their report, they explain that peak modeling 

represents a core component in preprocessing data 

for LC–MS studies. According to Yu and Peng, “To 

accurately quantify partially overlapping peaks, 

we developed a deconvolution method using the 

bi-Gaussian mixture model combined with statistical 

model selection.” 

This new method eventually may allow more complex 

biological samples to be tested, yielding a much more 

accurate analysis with LC–MS. 

A Japanese research group, led by Professor 

Ryusuke Kakigi and Dr. Emi Nakato (National Institute 

for Physiological Sciences) and Professor Masami 

K. Yamaguchi (Chuo University), has released a 

December 2010 Spectroscopy 25(12) 11 

study that used near-infrared (NIR) spectroscopy to 

evaluate which regions of infants’ brains are involved in 

processing positive and negative facial expressions. The 

study was published in the journal NeuroImage. 

In the study, NIR spectroscopy was used to measure 

changes in the concentrations of oxyhemoglobin, 

deoxyhemoglobin, and total hemoglobin as an index 

of neural activation in the superior temporal sulcus 

(STS) region of the brain. Neuroimaging studies in 

adults have revealed that several areas of the brain, 

including the STS, are involved in the processing of 

facial expressions. This study examined whether the 

STS is involved in such perception in infants as well. 

NIR spectroscopy is useful for such studies because it 

provides a non-invasive means of estimating cerebral 

blood flow and does not require severe constraints of 

head-movement. 

The study confirmed that the STS is involved in 

facial recognition in infants. The study also showed 

hemispheric differences: the left temporal area of 

infants’ brains was significantly activated for happy 

faces, while the right temporal area was activated 

for angry faces. According to the research group, the 

hemispheric lateralization of neural responses to facial 

expressions develops by the age of 6 months. ◾ 

Market Profile: Handheld and Portable NIR 

Demand for portable and handheld near infrared 

(NIR) instruments has exploded over the past several 

years, mirroring trends in other handheld spectroscopy 

techniques. Initially driven by the polymers and plastics 

industry, demand for the technique is now becoming 

significantly diversified, which should help drive strong 

growth for a number of years to come. 

Significant technological 

advancements have enabled the 

development of practical low-cost 

and rugged spectrometers over 

the past several years, including 

NIR-based instruments. Smaller 

and more powerful batteries 

and improved electronics have 

helped, but the application of 

micro electromechanical system 

(MEMS) technology to the area 

Environmental 

7% 

Pharmaceuticals 

18% 

Other 

10% 

was perhaps the most significant of these improvements. 

The plastics and polymers industry has accounted 

for the largest industrial demand thus far for handheld 

NIR instruments, which have seen heavy use in the 

classification of used plastics for recycling. Applications 

in agriculture and food are becoming increasingly 

important to the handheld and portable market, 

which is only natural because of the heavy use of other 

configurations of NIR spectroscopy in the industry. The 

use of portable and handheld NIR also is increasing for 

incoming material inspection in the pharmaceutical 

industry. 

Global demand for handheld and portable NIR 

developed from less than $10 million in 2005 to nearly 

$40 million in 2008 before being 

significantly impacted by the global 

Agriculture and food 

34% 

Polymers and plastics 

31% 

Portable NIR spectroscopy market in 2009 

recession in 2009. However, demand 

was expected to rebound strongly in 

2010 and should continue on a pace 

of double-digit growth for several 

years to come. 

The foregoing data were 

extracted from SDi’s market 

analysis and perspectives report 

entitled The Global Assessment 

Report 11th Edition: The Laboratory Life Science 

and Analytical Instrument Industry, October 2010. 

For more information, contact Stuart Press, Vice 

President, Strategic Directions International, Inc., 6242 

Westchester Parkway, Suite 100, Los Angeles, CA 90045, 

(310) 641-4982, fax: (310) 641-8851, www.strategicdirections.com.



The Baseline 

Neutron Spectroscopy 

Not all spectroscopy uses light . . . 

David W. Ball 

Most of us are at least nominally aware that light 

(rather, electromagnetic radiation) is not the only 

possible probe of matter and its behavior. One type 

of analysis uses neutrons as the probe of matter. As such, 

this is a form of neutron spectroscopy, or as it is more commonly 

called, neutron scattering. Neutron scattering is separated 

into two types: elastic neutron scattering and inelastic 

neutron scattering. In elastic neutron scattering, the neutrons 

have the same energy coming out of a sample as they 

did going in, while in inelastic neutron scattering the energy 

of the neutrons changes because of their interaction with 

matter. Here I will briefly introduce both types of scattering. 

Sources of Neutrons 

Neutrons are a kind of subatomic particle normally found 

in the nucleus of atoms. Hence, production of neutrons 

invariably requires nuclear processes. A common source of 

neutrons for research (as opposed to power generation) purposes 

is a small nuclear reactor that uses low-enriched uranium, 

or LEU. LEU is defined as uranium enriched in 235 U 

at concentrations less than 20% (natural uranium consists of 

0.7% 235 U). According to the International Atomic Energy 

Agency’s web site (1), at this writing there are currently 235 

reactors around the world that are supplying neutrons for 

research purposes. 

The other way of generating neutrons is by spallation, 

which is the name given to the process by which a target 

is hit with a projectile and pieces of the target are ejected 

as a result. In nuclear spallation, hydride ions (H – ) are accelerated 

by a particle accelerator, then stripped of their 

electrons down to the bare proton, which is accelerated 

further and directed to a heavy metal (like tantalum or 

mercury) target. As many as 20–30 neutrons are given 

off by the metal nucleus for each proton that impacts the 

nuclei. The neutrons are then directed toward various experiments. 

The person who first envisioned nuclear spallation? 

Glenn Seaborg. 

In many circumstances, neutrons that are produced by 

either method are too high in energy, so their energies must 

be decreased before they are used; we say that the neutrons 

must be moderated. Materials that moderate neutrons include 

light and heavy water, beryllium, and graphite. 

Neutrons are classified by their energies (expressed 

in electron-volts, eV), which are directly related to their 

velocities (in meters or kilometers per second) and temperatures 

(in kelvins). For a particle the size of a neutron 

(1.675 × 10 –27 kg), 1 eV of energy corresponds to a velocity 

of 13.8 km/s; keep in mind that the energy of a neutron 

depends on the square of the velocity (remember, K = ½ 

mv 2 ). As such, classification can imply a neutron’s velocity 

or its temperature. Fast neutrons have an energy of 0.1–1 

MeV (megaelectron-volt), or a velocity of 4000–14,000 

km/s. Slow neutrons have an energy of 100 eV or less, corresponding 

to a velocity of 138 km/s. (Take these numbers 

with a grain of salt; references can differ greatly about the 

energy and velocity cutoffs. It should be clear, however, 

that fast neutrons are, well, faster and more energetic than 

slow neutrons.) 

Thermal neutrons have an average temperature of room 

temperature, or about 295 K. This corresponds to an energy 

of 0.025 eV and a velocity of 2.2 km/s. Neutrons with an 

energy/velocity/temperature higher than this are called hot 

neutrons, and neutrons with an energy/velocity/temperature 

lower than this are called cold neutrons. Even within cold


neutrons, there are other classifications, 

going down to ultracold neutrons, 

which have energies in the range 

of nanoelectron-volts and velocities on 

the order of meters per second. 

One other thing to remember is that 

neutrons have an equivalent wavelength 

given by the de Broglie relation: 

λ 

λ = h/p = h/mv 

where λ is the de Broglie wavelength 

in meters, h is Planck’s constant in 

units of joule-seconds, m is the mass 

of a particle in kilograms, and v is the 

velocity of the particle in meters per 

second. For a neutron, h and m are 

constants (we’re assuming that most 

velocities are nonrelativistic, or that 

relativistic corrections — which for 

these neutrons are on the order of 1.5% 

at most — can be ignored), so the de 

Broglie relation reduces to 

d 

2Ө 

λ = (3.956 × 10 –7 )/v 

Thus, neutron wavelengths range 

from 2.8 × 10 –14 m (0.00028 Å) or 

smaller for fast neutrons to 1.8 × 

10 –10 m (1.8 Å) for thermal neutrons 

to 4.95 × 10 –8 m (495 Å, which is the 

same wavelength as extreme ultraviolet 

[EUV] light) for ultracold neutrons. 

Some forms of neutron scattering 

take advantage of the wave nature of 

neutrons. 

Elastic Neutron Scattering 

One application of elastic neutron 

scattering is neutron diffraction to 

determine structures of solid, liquids, 

and gases. Taking advantage of the 

neutron’s wave properties, neutron diffraction 

is very similar to X-ray diffraction. 

For example, it obeys the Bragg 

equation: 

nλ = 2d sin Θ 

where λ is the de Broglie wavelength 

of the neutrons, d is the distance 

between adjacent planes of scattering 

particles, Θ is the angle between 

the incoming neutron source and the 

plane of the scattering particles, and 

n is an integer called the order of the 

diffraction. Diffraction of neutrons 

Figure 1: Illustration of the geometry of the Bragg equation. 

is based on the production of constructive 

interference of the waves, as 

shown in Figure 1. 

Neutron diffraction has some advantages 

over X-ray diffraction. Perhaps 

most importantly, neutrons are 

diffracted from atomic nuclei rather 

than from electron clouds, so exact 

atomic positions are more accurately 

determined and hydrogen shows up 

explicitly (hydrogen atoms do not diffract 

X-rays well). Neutrons diffract 

better at high angles as well as low 

angles, so larger scattering angles can 

be probed, again increasing the resolution 

of the experiment. Because of 

the higher accuracy, neutron diffraction 

can be used to study the stress 

behavior of solids. 

Neutron diffraction suffers by requiring 

larger sample sizes, so single 

crystal neutron diffraction is rare; 

powdered samples are the norm. 

Certain atomic nuclei are also strong 

absorbers of neutrons, so they are 

not strong scatterers. The scattering 

vs. absorption of neutrons is isotopedependent, 

so different isotopes of the 

same element can be noticed. 

Elastic neutron scattering can also 

be used for reflectometry, which is a 

technique used to study thin films. 

As with neutron diffraction, neutron 

reflectometry provides complementary 

information compared to X-ray reflectometry. 

Inelastic Neutron Scattering 

In inelastic neutron scattering, the 

neutrons interact with a sample in such 

a way as to change their energies, getting 

either more or less energetic. In 

this regard, inelastic neutron scattering 

is very similar to classic forms of 

spectroscopy. Indeed, the experimental 

setup is also similar, as shown in Figure 

2. Some forms of inelastic neutron 

scattering use a monochromator, while 

others do not. 

In time-of-flight scattering, a polychromatic 

neutron pulse is chopped 

or monochromated and then sent 

through a sample. The sample diffracts 

neutrons having certain wavelengths 

(that is, certain energies) and at certain 

angles. The angles are measured by position-sensitive 

detectors, but the wavelengths 

(and therefore energies) of the



Neutron 

source 

Monochromator 

Initial E 

Sample 

Most neutrons 

Some neutrons 

Analyzer 

Final E 

The Nobel Prize in Physics 1994 

was awarded “ for pioneering contributions 

to the development of neutron 

scattering techniques for studies of condensed 

matter” jointly with one half to 

Bertram N. Brockhouse “ for the development 

of neutron spectroscopy” and 

with one half to Clifford G. Shull “ for 

the development of the neutron diffraction 

technique” (3). 

This achievement was recently noted 

in Spectroscopy’s timeline of events in 

the history of spectroscopy (4). Shull’s 

Wikipedia entry (5) claims that this 

was the longest time between the individual 

work performed (1946) and the 

awarding of the prize to date. 

neutrons are determined by measuring 

how much time it takes for the neutron 

signals to reach a detector. This indicates 

the neutron’s velocity, which is 

used in de Broglie’s relation to get the 

wavelengths of neutrons that are diffracted. 

Then the Bragg equation can 

be used to determine structural information 

of the sample. 

Neutron backscattering is a technique 

in which “diffraction” is set up 

so that the angles of the monochromator 

and analyzer are close to 90∘. Fast 

neutrons are directed toward a sample 

and a portion of them are scattered 

back near the source. Because small 

nuclei are better at scattering fast neutrons, 

an increase in the backscattering 

indicates a relatively higher proportion 

of smaller atoms like hydrogen. 

Neutron backscattering is used to find 

water in arid regions and to look for 

explosives in unexploded land mines; 

it has obvious implications in airport 

security. 

Neutron spin echo spectroscopy is 

an unusual form of spectroscopy that 

relies on the precession of a spinning 

neutron (spin quantum number = ½), 

although it is ultimately a type of timeof-flight 

measurement. A polarized 

beam of cold, polychromatic neutrons 

passes through a magnetic field, where 

the number of Larmor precessions of 

Detector 

Figure 2: Schematic of an inelastic neutron scattering experiment. Note its similarity to a regular 

spectroscopic setup. 

the neutrons are set depending on the 

length and strength of the magnetic 

field. The beam then scatters off a 

sample and the resulting precessions 

after scattering are determined using 

a second magnetic field. The difference 

in the number of precessions is 

an indication of the change in velocity 

— and therefore the change in energy 

— of the neutrons. In this case, however, 

the measurement is not a direct 

measure of the energy change, but is 

a time-dependent measurement that 

can be treated by a Fourier transform 

to convert it to the energy domain — 

that is, a spectrum. Neutron spin echo 

measurements have resolutions on the 

order of nanoelectron-volts. 

Neutron triple-axis spectrometry 

allows for the variations of three 

dimensions by being able to rotate 

a sample (typically a single crystal), 

the monochromator, and the detector 

independently (2). Energies probed 

include phonon modes of solids. 

Amorphous systems, proteins, aggregate 

motions of polymers and biological 

molecules, and energy transfer 

processes in liquids and glasses 

can be studied. This technique has 

become so useful in the study of the 

condensed phases of matter that its 

developers were awarded the 1994 

Nobel Prize in Physics: 

References 

(1) International Atomic Energy Agency 

website, http://www.iaea.org. 

Accessed September 22, 2010. 

(2) G. Shirane, S.M. Shapiro, and J.M. 

Tranquada, Neutron Scattering with a 

Triple-Axis Spectrometer: Basic Techniques 

(Cambridge University Press, 

2002). 

(3) http://nobelprize.org/nobel_prizes/ 

physics/laureates/1994/. Accessed 

October 4, 2010. 

(4) H. Mark and S. Brown, Spectroscopy 

25(6), 34–41 (2010). 

(5) http://en.wikipedia.org/wiki/Clifford_Shull. 

Accessed October 4, 2010. 

David W. Ball is a 

professor of chemistry at 

Cleveland State University 

in Ohio. Many of his 

“Baseline” columns have 

been reprinted in book 

form by SPIE Press as The 

Basics of Spectroscopy, available through 

the SPIE Web Bookstore at www.spie.org. 

His book Field Guide to Spectroscopy was 

published in May 2006 and is available 

from SPIE Press. He can be reached at 

d.ball@csuohio.edu; his website is 

academic.csuohio.edu/ball. 

For more information on 

this topic, please visit: 

www.spectroscopyonline.com/ball


Focus on Quality 

Fat Finger, Falsification, or Fraud? 

When does human error slide down the slippery slope to falsification and fraud? A central 

component of data integrity in any laboratory is the human element — the spectroscopist or 

the analytical chemist who will be involved with developing and validating methods or performing 

analysis on samples. Mistakes or fat finger moments are part of human nature, but 

where is the dividing line between this and falsification or fraud? 

R.D. McDowall 

So in the title I have suggested that there are three 

types of data integrity deviation: fat finger, falsification, 

and fraud. Here are my definitions of the terms: 

• Fat Finger: An inadvertent mistake made by an analyst 

during the course of his or her work that can be made 

either on paper or electronically. 

• Falsification: An action by an individual who deliberately 

writes or enters data or results with the intention to deceive. 

• Fraud: Collusion between two or more individuals who 

deliberately write or enter data or results with the intention 

to deceive. 

I have drawn a distinction in the definitions of falsification 

and fraud: Falsification is perpetrated by an individual 

and fraud by two or more people. However, the 

impact of both is the same: the intent to deceive. In writing 

this column, I have made the assumptions that each 

spectroscopist has a minimum level of scientific and 

professional training and will follow the documented 

analytical methods and laboratory SOPs. In addition, 

the organization the individual works for also has stated 

what ethical and professional standards it expects of its 

staff at their induction and via regular training sessions 

thereafter. 

To Err Is Human 

Mistakes and fat finger moments? If we are honest, we all 

make them. That is why any quality system for laboratories 

(for example, ISO 17025, GLP, and GMP) has the four 

eyes principle: One individual to perform the work and 

a second one to review the data produced to see that the 

procedure was carried out correctly and that there are no 

typographical errors or mistakes with calculations. Errors 

are easy to make; you should see the number I’m making 

as I type this column using a new PC that has a slightly 

larger keyboard than I am used to. 

Many errors and mistakes we make are self corrected. 

For example as you enter a number into a spreadsheet cell 

or database field, often you will notice that while the brain 

tells you to enter “12.3” your fingers actually enter “13.2.” 

This is a fat finger moment, but before committing the 

number to the cell or database you can correct this as you 

can see and have realized your error. The equivalent moment 

on paper is when you actually write the wrong numbers 

down in your laboratory notebook and then correct 

them by striking through the original entry so as not to 

obscure it and then entering the correct value along with 

your initials, the date, and possibly the reason for change. 

This is the paper version of an audit trail. 

Some other mistakes that are not noticed by the spectroscopist 

can be detected by the software application you 

are using, such as a spell checker, or by verification that 

the data entered fail to meet certain criteria, such as being 

within a predefined range or specific format. So with our 

example above, if the data verification range was 11.0–13.0,



the software would have picked up the 

problem even if you had not. 

However, that still leaves the 

mistakes you don’t realize you have 

made. For example, if the entry in the 

case above was 11.3, data verification 

would be useless and the error would 

have been entered without you or the 

software realizing that there was a 

problem. 

Don’t assume that you will spot all 

of your mistakes — they are human 

mistakes, which is why we need the 

second pair of eyes to check the analytical 

data and calculated results. 

From my experience as a laboratory 

manager and an auditor, supervisors 

know which members of their staff 

are diligent about their work and how 

well they check it and which members 

are slapdash, and the supervisor will 

adjust the review accordingly. So if 

you don’t want a dubious reputation 

to precede you, be diligent and try 

your best to find and correct your 

own errors before passing your work 

to be checked. 

What Is the Fat Finger Rate in a 

Laboratory? 

To a certain extent, this column is 

about airing dirty laundry, which 

may not be a particularly interesting 

problem to all but is the heart of any 

good quality management system: self 

audits coupled with effective corrective 

and preventative action planning. 

Quality is everybody’s problem, and 

it is not the sole responsibility of the 

quality assurance group to pick up the 

errors that the analytical laboratory 

has made. However, finding papers 

on how often we make mistakes in 

an analytical laboratory is difficult 

— probably because we don’t really 

want to go there. This, however, is the 

wrong approach to take and we should 

encourage studies to investigate this. 

Luckily help is at hand from clinical 

chemists working in hospitals 

who have published many studies on 

error rates in laboratories. For those 

that do not know, clinical chemistry 

is involved in the analysis of blood, 

urine, and other bodily outputs to 

help the diagnosis and management 

of diseases. Mistakes in this area can 

have a critical impact on the health of 

a patient and therefore the reduction 

in errors is essential. 

One paper, entitled “The Blunder 

Rate in Clinical Chemistry,” measured 

the rate of detected analytical 

errors before and after the introduction 

of a laboratory information management 

system (LIMS) and found 

that they were reduced from about 5% 

to less than 0.3% following the introduction 

of the computer system (1). 

Manual transcription errors in patient 

records were assessed for blood 

results recorded in a critical care setting 

by comparing the handwritten 

and printed laboratory results in 100 

consecutive patients in the intensive 

care unit of a UK hospital. Out of 

4664 individual values, 67.6% were 

complete and accurate, 23.6% were 

not transcribed at all, and 8.8% were 

inaccurate transcriptions of the results. 

Interestingly this study found 

that accuracy work was significantly 

better in the morning (2). 

An Australian study of transcribing 

hand-written pathology request 

forms to a computer systems and 

chemical analysis of the samples 

found that error rates were both in 

the 1–3% range in the best laboratories. 

The worst laboratories, however, 

had error rates of up to 39% in 

transcription and 26% in analytical 

results (3). 

So let us extrapolate from the clinical 

chemistry laboratory and suggest 

that error rates in an analytical 

laboratory are in the range of 0.3–3% 

depending on the degree of automation 

you have. The more manual 

input and transcription checking 

required, the greater the number of 

errors that need to be detected and 

captured. Therefore laboratory errors 

are expected by external quality audits 

and regulatory inspections. Not 

finding these detectable errors raises 

suspicion of problems with the resultant 

delving further into laboratory 

records. 

The Laboratory Notebook — 

Integrity or Falsification? 

This brings us to a common issue 

that we all have experience with: the 

humble laboratory notebook. Typically 

this is a bound book with prenumbered 

pages, just there to prevent 

you tearing out a page to write down 

the shopping list or make a paper airplane; 

it’s the first stage of ensuring 

data integrity in the laboratory. At the 

bottom of each page is space for you 

to sign and afterward a reviewer– 

supervisor–witness–peer to sign after 

checking your work and accepting it 

as accurate. 

OK, here’s the situation: You are 

a supervisor and you are checking a 

laboratory notebook for some current 

work, and in turning the page you 

notice that your signature is missing 

from when you reviewed some earlier 

work. Three out of four pages of the 

old work are signed and dated but 

you have neglected to sign one of the 

pages — so what do you do? Temptation 

time! You have the following 

options: 

1. Ignore the problem and wait for 

somebody else to discover it. 

2. Sign the page and date it the same 

as the other pages. 

3. Sign the page but date it with the 

current date and add a note that 

you have just noticed the problem. 

So what are you going to do? It is a 

pity that the paper and electronic versions 

of this magazine do not come 

with the possibility to fit a large hammer 

that will hit you over the head 

if you pick the wrong options. Most 

spectroscopists should reject the first 

option, especially if you are working 

in a research environment where 

product development and especially 

patent protection can be crucially 

dependent on the date of discovery. 

So we’re down to options 2 and 3. 

Option 2 is a little voice whispering 

in your ear “nobody will know if you 

put the same date that the other pages 

were signed on.” You can never find a 

hammer when you want one! You are 

now on the brink of the abyss — on 

the plateau is ethics and integrity and 

down the slippery slope is falsification 

and fraud. May I suggest that 

option 3 is the only option worth considering 

that will establish credibility 

for you and the laboratory? Reiterating 

the point in the section above and


putting my auditor’s hat on: I expect 

to see mistakes and if I don’t find any 

I become suspicious. 

Laboratory Fraud and 

Falsification 

Now let us move into the murkier 

world of falsification and fraud with 

the intent to deceive. A place that is 

very rich for finding examples dealing 

with both these issues is the FDA 

warning letters section found at 

www.fda.gov. The agency posts warning 

letters on its web site under the 

US Freedom of Information Act, with 

the intent of a name-and-shame approach. 

I quote these examples from 

the pharmaceutical industry; the FDA 

openly publishes this information, 

whereas the European regulators or 

ISO 17025 accreditation agencies usually 

keep it confidential. 

Four of the warning letters and 

regulatory issues that have emerged 

recently in this arena follow: 

• The classic fraud case involving 

laboratory data is that of Able 

Laboratories from 2005 (4). The 

company was engaged in a systematic 

laboratory fraud to pass 

batches of drug product that failed 

to meet specifications by changing 

weights and conversion factors 

and even cutting and pasting chromatograms. 

Results that failed were 

manipulated and faked until they 

passed — an original result for dissolution 

testing was ~30% versus a 

specification of >85% but after the 

magic fingers were applied the final 

result was ~89%! The company had 

passed several regulatory inspections 

until a whistleblower alerted 

the FDA to these practices. After a 

detailed inspection, the company 

withdrew several drug applications, 

recalled over 3100 batches of product 

and eventually went bankrupt. 

There was a subsequent criminal 

prosecution of four members of the 

company for fraud. 

• During an inspection of Ohm 

Laboratories in 2009, suspicion 

was aroused in the stability testing 

laboratory about material that 

had been taken out of the stability 

chambers for analysis. The material 

had been signed out by the stability 

coordinator but, as the warning 

letter noted, the attendance record 

showed that the stability coordinator 

was absent from the firm during 

those dates in which the coordinator 

recorded the withdrawal of 

samples from the stability chambers 

(5). This is very similar to the 

laboratory notebook example we 

discussed above. 

• A Chinese company, Xian Libang 

Pharmaceutical Co. (6), was found 

to have used the IR spectra from 

one batch of material to support the 

release of two subsequent batches. 

The warning letter noted that this 

practice is unacceptable and raises 

serious concerns regarding the integrity 

and reliability of the laboratory 

analyses conducted by your firm. It 

is essential that at least one test be 

conducted to verify the identity of 

each lot of incoming material. In addition, 

the laboratory control records 

should include complete documentation 

of all raw data generated during 

each test, including graphs, charts, 

and spectra from laboratory instrumentation. 

These records should be 

properly identified to demonstrate 

that each raw material batch was 

tested and met the release specification 

before its use in production. 

. . . A cursory review of records is 

not sufficient to ensure that other 

personnel did not manipulate or 

inaccurately report test data. It is 

interesting to note that after finding 

falsification in one analysis, the 

agency, quite rightly, casts doubt on 

the whole laboratory. 

• There was a further citation about 

the lack of controls to prevent 

manipulation of raw data during 

routine analytical testing and how 

measures would be put in place to 

stop unauthorized changes being 

made to data in the future. The 

agency wanted to see a process to 

prevent omissions in data, but also 

for recording any changes made to 

existing data, which should include 

the date of change, the identity of 

the person who made the change, 

and an explanation or reason for the 

change. All changes to existing data 

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should be made in accordance with 

an established procedure. 

• My last example is recent and cost 

a European generic drug manufacturer 

a loss of $3.3 million earlier 

this year (7). Acino, a Swiss generic 

drug manufacturer, contracted 

Glochem, an Indian company, to 

supply clopidogrel, which is the active 

ingredient of Plavix. Following 

a visit by European inspectors to 

the Indian company, they found 

more than 70 original batch records 

in a dumpster at the site; all 

the records had been rewritten to 

be perfect with no errors, in total 

contradiction of Good Manufacturing 

Practice (GMP). The inspectors, 

again quite rightly, classified this as 

fraud and this triggered a recall of 

the material. In response, the company 

thought that the inspector’s 

response was excessive and commissioned 

an extensive third-party 

analysis to demonstrate that the 

material met specifications. However, 

as the batch records had been 

copied and the originals were in the 

process of being destroyed, the inspectors 

held to their original view. 

You can see from these few examples 

that by being diligent, honest, 

and professional you can avoid the 

problems faced by these companies. 

The fourth example also illustrates 

that if a company outsources to a 

third party, the first company is still 

accountable for the quality of the material 

going into its own supply chain 

Proactive auditing will help prevent 

these issues. 

How Should We Prevent Fraud 

and Falsification? 

There are a number of ways that we 

can avoid the problems of fraud and 

falsification. The first is to develop 

clear written policies and procedures of 

what is expected when work is carried 

out in any laboratory; the integrity of 

the data generated in the laboratory is 

paramount and must not be compromised. 

Coupled with this is the need to 

provide initial and on-going training 

in this area. The training should start 

when new spectroscopists join the laboratory 

and should continue as part of 

their ongoing training over the course 

of their careers. 

To help training staff we need to 

know the basics of laboratory data 

integrity. The main criteria are listed 

below. Data must be: 

• Attributable — Who acquired the 

data or performed an action and 

when? 

• Legible — Can you read the data and 

any laboratory notebook entries? 

• Contemporaneous — Documented 

at the time of the activity. 

• Original — A written printout or observation 

or a certified copy thereof. 

• Accurate — No errors or editing 

without documented amendments. 

• Complete — All data including any 

repeat or reanalysis performed on 

the sample. 

• Consistent — All elements of the 

analysis such as the sequence of 

events follow on and are date or time 

stamped in the expected sequence. 

• Enduring — Not recorded on the 

back of envelopes, cigarette packets, 

sticky notes, or the sleeves of 

a laboratory coat but in laboratory 

notebooks or electronic media in 

the data systems of instruments and 

LIMS. 

• Available — Can be accessed for 

review and audit or inspection over 

the lifetime of the record. 

Spectroscopists need to understand 

these criteria and apply them in their 

respective analytical methods. 

To support human work, we should 

also provide automation in the form 

of integrated laboratory instrumentation 

with data handling systems and 

LIMS as necessary to perform the 

work. In any laboratory this integration 

needs to include effective audit 

trails to help maintain data integrity 

and monitor changes to data. Supervisors 

and quality personnel need to 

monitor these audit trails to assess the 

quality of data being produced in a 

laboratory; if necessary a key performance 

indicator (KPI) or measurable 

metric could be produced. Finally, if 

all else fails, disciplinary procedures 

need to be in place and should be 

used to resolve any problem, because 

the reputation of the laboratory is of 

prime importance. 

Conclusions 

In this column I have looked at errors 

caused by fat finger moments that are 

normal and why we need a second 

person to check our data and ensure 

that they are correct. These errors 

can be reduced by using automation 

to transfer data automatically and 

eliminate the need for manual entry 

of data followed by transcription 

error checking. We have also looked 

at falsification and fraud with ways 

of ensuring that none occur in your 

laboratory. 

References 

(1) A.M. Chambers, J. Elder, and D. St. J. 

O’Reilly, Annals Clinical Biochemistry 

23, 470–473 (1986). 

(2) R. Black, P. Woolman, and J. Kinsella, 

presented at American Society of Anaesthesiologists 

Annual Meeting, New 

Orleans, LA, October 2001. 

(3) M. Khoury, L. Burnett, and M.A. 

Mackay, The Medical Journal of Australia 

165, 128–130 (1996) (http:// 

www.mja.com.au/). 

(4) R.D. McDowall, Quality Assurance 

Journal 10, 15–20 (2006). 

(5) Ohm Laboratories, Warning Letter 

(December 2009). 

(6) Xian Libang Pharmaceutical Company, 

Warning Letter (January 2010). 

(7) J.-F. Tremblay, Chemical & Engineering 

News 88(34), 23 (August 23, 

2010). 

R.D. McDowall 

is principal of Mc- 

Dowall Consulting 

and director of R.D. 

McDowall Limited, 

and the editor of the 

“Questions of Quality” 

column for LCGC 

Europe, Spectroscopy’s sister magazine. Address 

correspondence to him at 73 Murray 

Avenue, Bromley, Kent, BR1 3DJ, UK. 



www.spectroscopyonline.com/mcdowall


Spectroscopy Market: 

Weathering the Storm and 

on the Path to Recovery 

The spectroscopy market is expected to rebound from 2009 and surge toward 

market-high revenues, with technical developments and product innovation 

driving the growth. 

Sivakumar Narayanaswamy 

After weathering the economic downturn of 2009, 

the analytical instrumentation industry’s business 

appears to have made a U-turn in 2010, primarily 

due to the burgeoning requirements of the life sciences 

and pharmaceutical industries and substantial demands 

from the chemical and petrochemical industries, in addition 

to growing environmental concerns. The analytical 

instrumentation industry managed the economic downturn 

better than most other industries even though some of its 

primary revenue streams, such as the replacement market, 

were hurt by procurement postponements. 

Competition in the process analytical instrumentation 

market is intense, with large conglomerates competing 

among themselves and with niche market participants. 

With multinational participants accounting for more than 

half the revenue shares in this market, consolidation due to 

mergers and acquisition is set to further augment competition 

among key participants in this mature market. This 

results in declining prices affecting market revenues and 

vendor profit margins. The market participants should consider 

strategies to overcome this challenge in this highly 

competitive market by investing in research and development 

(R&D). This would result in new product innovations 

that could offer greater accuracy and reliability, besides 

being price competitive. 

The spectroscopy market segment accounts for approximately 

35.0% of total analytical instrumentation market 

revenues and is currently witnessing significant changes, 

with many new product introductions. This helps manufacturers 

provide better solutions that meet customer demands. 

This sector caters to many specialized applications 

across several end-users including chemical and petrochemical, 

oil and gas, life sciences (includes pharmaceutical 

and biotechnology), food safety, forensics, and so forth. 

With numerous technologies present in this market, it can 

be broken down into molecular spectroscopy, atomic spectroscopy, 

and mass spectrometry markets, with further 

classifications in each of them. 

The spectroscopy market can also be broadly split into 

laboratory and process (online and in-situ) types depending 

on the location and usage of these instruments. The 

laboratory spectroscopy market is driven by adoption of 

these instruments for offline analysis. By combining many 

aspects of a laboratory instrument and a process control 

instrument, process spectroscopy enables process monitoring 

for improved product quality and efficient process control. 

At the beginning of the economic recession in 2009, 

several end-user industries started emphasizing the need 

to increase process throughput and efficiency by reducing 

delays in reporting. This need led to an increase in uptake 

of process spectroscopy instruments that provide more 

comprehensive, precise, and accurate information, faster 

than other laboratory instruments. 

Mass Spectrometry Market to Lead Recovery 

In the molecular spectroscopy market, product sales of 

infrared, near-infrared (NIR), and Raman instrumentation 

have picked up considerably in 2010, aided by stimulus 

packages, academic and research institutions, and 

government defense and homeland security spending. In 

2009, nuclear magnetic resonance (NMR) spectroscopy, 

the largest segment in this molecular spectroscopy mar-



ket, witnessed a decline in revenues 

mainly due to customers refraining 

from purchasing this high-cost product. 

Historically, revenues from this 

segment are mainly attributed to replacement 

sales, solely because of its 

high installed base population. Ultraviolet–visible 

(UV–vis) spectrometers 

and Fourier-transform infrared (FT- 

IR) spectrometers and other molecular 

spectroscopy market segments are 

expected to support the growth of this 

market in the next few years. 

The atomic spectroscopy market is 

projected to expand significantly in 

the near term due mainly to demand 

from the life sciences sector with significant 

contribution from the X-ray 

diffraction product type. Revenues in 

the atomic absorption (AA) spectroscopy 

market in 2009 were supported 

by strong environmental sector sales, 

which balanced the decrease in sales 

in the global minerals and metals sector 

that pulled down market revenues. 

Mass spectrometry products contribute 

a significant portion of revenues 

in the spectroscopy market. In 2010, 

revenues were estimated to be $1.8 

billion and the market is expected to 

grow at a compounded annual growth 

rate of 4.0% for the period 2010–2014. 

The use of these products in tandem 

with chromatographic separation techniques 

such as gas chromatography– 

mass spectrometry (GC–MS), liquid 

chromatography–mass spectrometry 

(LC–MS) and ion mobility spectrometry–mass 

spectrometry (IMS–MS) 

has resulted in their widespread use 

due to increased capabilities. These 

combination instruments, also referred 

to as hyphenated systems, have 

shown remarkable growth rates in the 

recent past and are expected to grow at 

a steady pace. Also, inductively coupled 

plasma mass spectrometry (ICP-MS) is 

expected to replace inductively coupled 

plasma optical emission spectrometry 

(ICP-OES) because of its robustness, 

linear range, and matrix tolerance. 

Into its fourth decade, ICP-MS 

serves as a valuable tool in the multielement 

analysis that is used in a 

wide range of applications, including 

metallomics, bioimaging, proteomics, 

speciation analysis, and nanoscience 

(1). In 2009, underwhelming market 

trends hurt revenues in the ICP-MS 

market. But since Q3 of 2010, new 

product introductions and ICP’s 

scope as a replacement product for 

other atomic spectroscopy instruments 

provided vendors in the ICP 

market ample opportunities resulting 

in higher revenue earnings in this 

product segment. Moreover, its application 

in elemental trace analysis and 

its higher price/performance ratio, in 

addition to its ease-of-use, drive sales 

of this product. Also, for its ability 

to provide a more detailed elemental 

analysis it scores high against AA 

spectroscopy, which is a cheaper alternative 

but is capable of performing a 

more limited elemental analysis. 

Because spectroscopic techniques 

enable rapid, nondestructive analysis of 

samples, the pharmaceutical industry 

remains a key end-user. Nondispersive 

NIR spectroscopy is ideal for pharmaceutical 

tablets as it enables sampling 

by volume. As new pharmaceutical 

regulations require accurate analysis of 

finished pharmaceutical products such 

as tablets and capsules, analysts need 

spectrometers to verify and analyze 

compliance of their products with the 

required quantity of active ingredient. 

Traditionally, this analysis was performed 

with a high performance liquid 

chromatography (HPLC) system. Currently, 

the NIR spectroscopy technique 

is rapidly being used in this industry 

due to its implementation flexibility 

and accurate analysis capability. 

Life Science and Petrochemical 

to Boost Revenues 

The life science sector was one of the 

saviors of the spectroscopy market 

in 2009. Constant demand from this 

industry cushioned the impact of the 

downturn, positioning the spectroscopy 

market for a quick recovery as 

the economy gradually climbs out of 

recession. With support from the two 

main sectors within life sciences — 

namely pharmaceutical and medical 

biotechnology — the spectroscopy 

market is likely to witness increased 

demand in the next couple years. 

The importance of environmental 

applications also is growing, as process 

spectrometers are increasingly 

being used to monitor wastewater and 

process water for contaminants. This 

increase in demand for process spectrometers 

is due to the need to keep 

environmental degradation in check 

by monitoring effluents and process 

and potable water. 

Petroleum demand in North America, 

particularly in the United States, 

continues to increase through 2010 

after the economic stagnation in 2009. 

With the economy recovering well and 

resulting in a positive impact on enduser 

industries, especially the chemical 

and petrochemical industries, the 

increased industrial activity is aiding 

in the growth of the analytical instrumentation 

market. The spectroscopy 

market is expected to gain from this 

sector’s improved performance with 

an increase in mass spectrometry segment 

revenues expected in the next 

couple of years. 

In 2010, the outlook for the semiconductor 

industry looks bright with 

industry reports highlighting consistently 

increasing sales volumes. This 

augurs well for the ICP segment of 

the spectrometry market because this 

technique typically addresses the sensitivity 

factor of measurement, which 

is expected to drive growth in the next 

couple of years. 

An important consumer of AA 

spectroscopy products is the mines 

and minerals industry, the growth of 

which has declined since mid 2008, 

hurting spectroscopy revenues from 

this industry. Only regional environmental 

regulations provided a certain 

level of buoyancy for this market, 

which reported a growth of 3.2% in 

2009. The year 2010, however, witnessed 

renewed interest in the minerals 

and mines industry, which usually 

supports high end products resulting 

in increased sales and a higher growth 

rate. It is expected that at the turn of 

the year the revenues of the AA spectroscopy 

market segment will reach 

$1.9 billion and would report a growth 

rate of 4.5%. 

Asia Pacific: The Leading Light 

Traditionally, the United States and 

Europe along with Japan contribute


a major part of the revenues of the 

total spectroscopy market. In Europe, 

the United Kingdom leads in the life 

science industry with about 600 and 

780 companies in the pharmaceutical 

and medical biotechnology sector 

that have a combined annual turnover 

of around £19.8 billion, which 

represents about 4.5% of the global 

turnover and 15.7% of the total European 

turnover (2). However, even 

though several key indicators such 

as industrial production and capacity 

utilization have shown increasing 

trends since the beginning of 2010, 

several issues such as the European 

debt crisis are likely to affect growth 

in the short term. 

Asia Pacific is growing the fastest, 

with major contributions from China 

and India where a huge demand for 

spectrometers is generated from 

greenfield projects that are being set 

up in various end-user industries. 

The region’s life science industry is 

robust and is expected to contribute 

hugely to spectroscopy market growth 

in the coming years. 

Consolidation to Determine the 

Leader 

The public and private funding bodies 

in the European Union support 

investments in clinical and molecular 

research resulting in the continued 

growth of this market over the next 

couple of years. This is likely to result 

in steady growth for the spectroscopy 

market. The technique’s capability to 

analyze proteins and metabolites results 

in the increased usage of spectrometers 

in the fields of medical research 

and clinical diagnostics and is 

likely to be complemented by the rapid 

implementation of this technique in 

the medical field. 

LC–MS instruments are widely 

used in pharmaceutical manufacturing 

processes, including process 

development research, manufacturing, 

and quality control. These instruments 

rode out the wave of the 

pharmaceutical industry’s slower 

performance in 2009, following which 

2010 has been a better year. Besides 

pharmaceutical applications, these 

instruments are also applied in biotechnology, 

food safety, chemical, 

petrochemical, forensics, homeland 

security, environmental, academic, 

and government markets. 

Consolidation in this market is 

not as vigorous as in the overall 

analytical instrumentation market, 

although Bruker’s acquisition of the 

laboratory GC, GC–MS-MS, and 

ICP-MS product lines of Varian Inc. 

in 2010 enabled Bruker to expand 

its mass spectrometry portfolio into 

the chemical analysis markets. In the 

short and medium terms such inorganic 

growth options are likely to 

lead to more market consolidation. 

In particular, the pharmaceutical 

industry’s process analytical technology 

(PAT) initiative, global green 

environment initiatives supported 

by regional regulations and demand 

from the chemical and petrochemical 

industries are likely to drive the demand 

for process spectroscopy instruments 

over the next couple of years. 

Another growth area in the spectroscopy 

market is the handheld or 

the portable type. This reflects the 

trend toward miniaturization in all 

products in all industrial products. 

Innovative Market Participants 

to Succeed 

The spectroscopy market is mainly 

technology oriented and the market 

rankings of market participants are 

likely to be governed by the innovations 

and annual R&D allocations 

made each year. New product introductions 

have occurred even during 

the economic recession as many of 

the participants spend considerable 

amounts of money on R&D activities. 

Some of the key participants in this 

market include Agilent Technologies 

Inc., Applied Biosystems Group, 

Bruker Daltonics Inc., JEOL Ltd., 

PerkinElmer Inc., Shimadzu Corporation, 

Thermo Fisher Scientific, and 

Waters Corporation. Most of these 

participants are headquartered in 

the United States or Europe and have 

sales and marketing operations in 

Asia Pacific and rest-of-world (RoW) 

regions. 

With higher demand in the developing 

countries in Asia Pacific and 

RoW regions, the vendors in this 

market are already strengthening 

their presence in these regions with 

improved distribution networks in 

addition to setting up manufacturing 

units, which is likely to result 

in long-term returns beyond 2010. 

For example, in 2010, Agilent Technologies 

started manufacturing mass 

spectrometer products in Singapore 

to increase its focus in this region. 

Conclusion 

The current economic environment 

promises to aid growth across most 

end-user industries in the spectroscopy 

market. In 2010 and beyond, it is 

expected that this market will recover 

from the dip witnessed in 2009 and 

surge toward market high revenues. 

Technical developments and product 

innovation are expected to drive 

the market along the growth curve. 

The molecular spectroscopy and mass 

spectrometry markets are expected to 

witness higher growth rates and improve 

their share in the process analytical 

instrumentation market. 

With many pharmaceutical and 

biotechnology companies relocating 

their manufacturing and R&D activities 

to China and India, these two 

growth engines of Asia are poised to 

improve their contributions. The next 

few years will see Asia Pacific emerging 

as significant markets for spectroscopy 

products. 

References 

(1) C. Engelhard, Anal. Bioanal. Chem. 

(epub ahead of print, October 29, 

2010). 

(2) Life Science 2010: Delivering the Blueprint, 

Department of Business, Innovation 

and Skills, UK (January 2010). 

Sivakumar Narayanaswamy is 

an Industry Analyst for Frost & Sullivan’s 

Measurement & Instrumentation Group. 

For more information on this topic, 

please visit our homepage at: 

www.spectroscopymag.com



May 2010 Volume 25 Number 5 www.spectroscopyonline.com 

November 2010 Volume 25 Number 11 www.spectroscopyonline.com 

e 25 Number 6 www.spectroscopyonline.com 

Volume 25, 2010 

0 Volume 25 Number 11 

spectroscop 

opyon 

2010 Editorial Index 

AUTHORS 

A 

Adar, Fran. “Analysis of Lignin and Cellulose in Biological 

Energy Sources by Raman Microscopy,” in 

Molecular Spectroscopy Workbench. February, p. 18. 

Adar, Fran. “Depth Resolution of the Raman Microscope: 

Optical Limitations and Sample Characteristics,” 

in Molecular Spectroscopy Workbench. 

March, p. 16. 

Adar, Fran. “Thoughts About ICORS 2010 and Where 

Raman Spectroscopy Is Headed,” in Molecular Spectroscopy 

Workbench. October, p. 16. 

Adjei-Bekoe, Gloria. See Martin, John E. 

Ahn, Joomi; Ivleva, Vera; Skilton, St John; and Yu, 

Yingqing. Branching Out: Mass Spectrometry and 

the Shape of Biotherapeutics. Current Trends in Mass 

Spectrometry, May, p. 28. 

Akao, Ken-ichi. See Larsen, Richard A. 

Almeida, Manuel; Rury, Maura; Condon, John; and 

Brown, Peter. Determination of Trace Elements 

in Over-the-Counter Cough Syrup by Inductively 

Coupled Plasma–Optical Emission Spectroscopy. Applications 

of ICP & ICP-MS Techniques for Today’s 

Spectroscopists, November, p. 12. 

Anderson Smith, Lea L. See Martin, John E. 

Atkins, Patricia; Ernyei, Laszlo; Sivakumar, Vanaja; 

and Obenauf, Ralph. A Common Sense Laboratory 

Guide to Reducing Errors and Contamination in 

ICP and ICP-MS Analysis. Applications of ICP & 

ICP-MS Techniques for Today’s Spectroscopists, 

November, p. 42. 

B 

Ball, David W. “Group Theory and Symmetry, Part II: 

Groups,” in The Baseline. January, p. 18. 

Ball, David W. “Group Theory and Symmetry, Part III: 

Representations and Character Tables,” in The Baseline. 

April, p. 16. 

Ball, David W. “Group Theory and Symmetry, Part IV: 

Great or Grand, We’ve Got GOT,” in The Baseline. 

September, p. 18. 

Ball, David W. “Happy Sesquicentennial, Spectroscopy,” 

in The Baseline. June, p. 16. 

Ball, David. “Neutron Spectroscopy,” in The Baseline. 

December, p. 12. 

Baum, Andreas; Lu, Yao; Muccio, Zeland; Jackson, 

Glen P.; and Harrington, Peter B. Differentiation Between 

Origins of Extra Virgin Olive Oils by GC–C- 

IRMS Using Principal Component Analysis, Linear 

Discriminant Analysis, and Hierarchical Cluster 

Analysis. February, p. 40. 

Begley, Benjamin. See Thakur, Rohan A. 

Bettmer, Jörg. See Hamester, Meike. 

Binkley, Joe; and Libarondi, Mark. Comparing the Capabilities 

of Time-of-Flight and Quadrupole Mass 

Spectrometers. Current Trends in Mass Spectrometry, 

July, p. 28. 

Boquet, Don. See Rodgers, James. 

Bowerbank, Christopher R. See Lee, Edgar D. 

Bradley, Mike; and Hirsch, Jeffrey. Improved FT-IR 

Instrumentation and Software for Complete Confidence 

in QA/QC Testing. FT-IR Technology for 

Today’s Spectroscopists, August, p. 24. 

Briggs, Jenni L. Hollow Waveguides: The Next Generation 

of Mid-IR Remote Sampling Accessories. 

FT-IR Technology for Today’s Spectroscopists, August, 

p. 36. 

Brown, Christopher D. See Green, Robert L. 

Brown, Peter. See Almeida, Manuel. 

Brown, Steve. See Mark, Howard. 

Buckley, Steve. See Eichenholz, Jason.


Bukowski, Nick. TOF-MS: A Viable 

Solution for Crude Oil Extract 

Analysis. Current Trends in Mass 

Spectrometry, May, p. 22. 

Busch, Kenneth L. “A Random Walk 

Through the Web of Mass Spectrometry,” 

in Mass Spectrometry 

Forum. March, p. 24. 

Busch, Kenneth L. “Derivatization 

in Mass Spectrometry,” in Mass 

Spectrometry Forum. November, 

p. 18. 

Busch, Kenneth L. “Ion Burn and 

the Dirt of Mass Spectrometry,” 

in Mass Spectrometry Forum. 


Busch, Kenneth L. “Mass Spectral 

Libraries: The Next Generation,” 

in Mass Spectrometry Forum. 

January, p. 24. 

Busch, Kenneth L. “Mass Spectrometry–Mass 

Spectrometry Retrospective,” 


Forum. July, p. 14. 

C 

Cassap, Matthew. Using ICP-OES 

for Accurate Monitoring of Metallic 

Contaminants in Water 

According to U.S. EPA Method 

200.7. May, p. 64. 

Chang, James S. See Zhang, Allen. 

Christesen, Steven D. See Emmons, 

Erik D. 

Churley, Melissa. See Macherone, 

Anthony. 

Clawson, Ernest. See Rodgers, 

James. 

Cognard, Emmanuelle. See Jenkins, 

Tim J. 

Condon, John. See Almeida, Manuel. 

Countryman, Sky. See Sanchez, Carl. 

Coutinho, Carlos Augusto. See 

Thomsen, Volker. 

Cui, Xiaoliang. See Rodgers, James. 

Curtis, Matthew. See Sparkman, O. 

David. 

D 

David, Frank. See Vanhoenacker, 

Gerd. 

Davidonis, Gayle. See Rodgers, 

James. 

Dey, Dipankar. See Taday, Philip F. 

Dickson, Hazel. “Atomic Absorption: 

Feeding the Food Safety Market,” in 

Atomic Perspectives. July, p. 26. 

Dieing, T. See Schmidt, U. 

Dodds, Walter K. See Murdock, 

Justin N. 

Dong, Dahai. See Thakur, Rohan A. 

Dowd, Mick. See Hirsch, Jeffrey. 

Drapcho, David; Zlatkin, Igor; Inscore, 

Frank; Shende, Chetan; 

Sengupta, Atanu; Huang, 

Hermes; and Farquharson, Stuart. 

High-Throughput Trace Analysis 

Using SERS-Active Microtiter 

Plates with a Raman Plate Reader. 

Raman Technology for Today’s 

Spectroscopists, June, p. 42. 

E 

Eichenholz, Jason; Kaye, Kevin; 

and Buckley, Steve. Laser-Based 

Technologies Target Terrorists. 

Defense and Homeland Security, 

April, p. 26. 

Emmons, Erik D.; Tripathi, Ashish; 

Guicheteau, Jason A.; Christesen, 

Steven D.; and Fountain III, Augustus 

W. Raman Chemical Imaging 

of Explosive Contaminated 

Fingerprints for Forensic Applications. 

Defense and Homeland 

Security, April, p. 8. 

Ernyei, Laszlo. See Atkins, Patricia. 

Evans, Christopher A. See Plumb, 

Robert S. 

Evans, Megan. 58th ASMS Conference 

Review. Current Trends in 

Mass Spectrometry, July, p. 44. 

Evans, Megan. 2010 Salary Survey: 

A Year of Pluses and Minuses. 

March, p. 36. 

Evans, Michael. See Taday, Philip F. 

F 

Fahrenholz, Timothy M. See Rahman, 

G.M. Mizanur. 

Farquharson, Stuart. See Drapcho, 

David. 

Ferguson, Jim. See Ghobarah, Hesham. 

Fortier, Chanel. See Rodgers, James. 

Fountain III, Augustus W. See Emmons, 

Erik D. 

G 

Gerhards, Petra; Schanen, Pierre; 

and Horner, Gerhard. Using 

Novel TOF-MS to Increase Sensitivity 

and Confidently Detect 

Drugs of Abuse in Urine. Current 

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of sample/salt mix prior to HPLC 

www.retsch-us.com/mm400 

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Trends in Mass Spectrometry, October, 

p. 18. 

Ghobarah, Hesham; Ramagiri, 

Suma; and Ferguson, Jim. Increasing 

Productivity of ADME 

Studies Using Accurate Mass 

Technology. Current Trends in 

Mass Spectrometry, October, p. 

39. 

Goshawk, Jeff. See Yu, Kate. 

Green, Robert L.; Hargreaves, Michael 

D.; and Brown, Christopher 

D. Handheld FT-IR and Raman 

as Tools in the Analysis of Improvised 

Explosive Materials. 

Defense and Homeland Security, 

April, p. 14. 

Gu, Christine. See Zhang, Allen. 

Gu, Ming. Enhancing Mass Spectral 

Formula Determination by 

Heuristic Rules. Current Trends 

in Mass Spectrometry, May, p. 42. 

Gudihal, Ravindra. See Waddell, 

Keith. 

Guicheteau, Jason A. See Emmons, 

Erik D. 

Gygi, Steven P. Phosphorylation Site 

Localization Using Probability- 

Based Scoring. Current Trends 

in Mass Spectrometry, October, 

p. 28. 

H 

Hamester, Meike; McSheehy, Shona; 

Kutscher, Daniel J.; Konz, Tobias; 

and Bettmer, Jörg. Reliable 

and Efficient Sulfur Detection in 

Proteins Using ICP-MS with Capillary 

LC. Current Trends in Mass 

Spectrometry, October, p. 21. 

Hancock, Peter. See Jenkins, Tim J. 

Hargreaves, Michael D. See Green, 

Robert L. 

Harrington, Peter B. See Baum, Andreas. 

Heim, John; and Staples, Doug. 

Using Comprehensive GC×GC– 

TOF-MS for Enhanced Detection 

and Separation in Antidoping 

Control Screening. Current 

Trends in Mass Spectrometry, 

May, p. 16. 

Heim, John. Analyzing Small Molecule 

Metabolite Profiles of 

Diabetic and Nondiabetic Urine 

Samples Using GC×GC–TOF- 

MS and Statistical Software as a 

Data Mining Strategy. Current 


March, p. 30. 

Hinrichs, Joachim. See Oki, Tomoko. 

Hirsch, Jeffrey; Lowry, Steven R.; 

and Dowd, Mick. X-Ray Fluorescence 

and FT-IR Identification 

of Strontium and Carbonate in 

Domestic and Imported Gypsum 

Drywall. July, p. 30. 

Hirsch, Jeffrey. See Bradley, Mike. 

Hollricher, O. See Schmidt, U. 

Horner, Gerhard. See Gerhards, 

Petra. 

Huang, Hermes. See Drapcho, 

David. 

Hwang, J. David. See Rahman, G.M. 

Mizanur. 

I 

Inscore, Frank. See Drapcho, David. 

Ivleva, Vera. See Ahn, Joomi. 

J 

Jackson, Glen P. See Baum, Andreas. 

Jauss, A. See Schmidt, U. 

Jenkins, Tim J.; Worrall, Keith; 

Hancock, Peter; Morphet, James; 

Cognard, Emmanuelle; and Ortelli, 

Didier. Advancing TOF-MS– 

Based Screening for Food Safety 

Residue Analysis with a Positive 

Approach. Current Trends in 

Mass Spectrometry, March, p. 25. 

Jones, Patrick R. See Sparkman, O. 

David. 

Ju, June-Sik. See Kim, Seung-Hyun. 

K 

Kang, Sho Yeung. See Rodgers, 

James. 

Kaufmann, Ken. “CMOS Technology 

for Scientific Imaging,” in Laser 

and Optics Interface. July, p. 20. 

Kaye, Kevin. See Eichenholz, Jason. 

Kim, Ho-Dong. See Kim, Seung- 

Hyun. 

Kim, Seung-Hyun; Ju, June-Sik; 

Shin, Hee-Sung; Kim, Ho-Dong; 

and Yee, Ki-Ju. A Quantitative 

Analysis of Neodymium and 

Samarium at Low Pressure by 

Laser-Induced Breakdown Spectroscopy. 


Kingston, H.M. Skip. See Rahman, 

G. M. Mizanur. 

Koerner, Philip J. See Sanchez, Carl. 

Koetzner, Lee. See Thakur, Rohan A. 

Koleto, Michael. See Thakur, 

Rohan A. 

Konz, Tobias. See Hamester, Meike. 

Koshoubu, Jun. See Larsen, 

Richard A. 

Kutscher, Daniel J. See Hamester, 

Meike. 

L 

Larsen, Richard A.; Akao, Ken-ichi; 

Koshoubu, Jun; and Sugiyama, 

Hiroshi. Using FT-IR Microscope 

ATR Objectives to Resolve Complex 

Samples. FT-IR Technology 

for Today’s Spectroscopists, August, 

p. 42. 

Later, Douglas W. See Lee, Edgar D. 

Lee, Edgar D.; Smith, Philip A.; 

Bowerbank, Christopher R.; and 

Later, Douglas W. Rapid Chemical 

Threat Identification by 

SPME-GC–TMS. Defense and 

Homeland Security, April, p. 30. 

Lee, Eunah; and Adar, Fran. Transmission 

Raman: A Method for 

Quantifying Bulk Materials. 



Leona, Marco. See Tague Jr., Thomas 

J. 

Li, Yaping; Li, Qingbo; and Zhang, 

Guangjun. Near-Infrared Spectrophotometric 

Analysis of 

Human Blood Glucose: Influence 

of Repeating Errors on Prediction 

Accuracy. June, p. 46. 

Libarondi, Mark. See Binkley, Joe. 

Lindemann, Torsten. See Oki, Tomoko. 

Litchfield, David W. See Zhang, 

Cunjie. 

Lowry, Steven R. See Hirsch, Jeffrey. 

Lu, Yao. See Baum, Andreas. 

M 

Macherone, Anthony; Churley, 

Melissa; and White, Robert. Ultralow 

Detection of Estrogenic 

Compounds by GC–NCI-MS-MS. 

Current Trends in Mass Spectrometry, 

May, p. 10. 

Macho, Jorge. Low-Resolution 

Raman Spectroscopy in Science 

Education. Raman Technology 

for Today’s Spectroscopists, 

June, p. 12.


MacRae, Michael. Spectroscopy 

Uncensored: An Insider’s Story 

of the First 15 Years. June, p. 26. 

Magarini, Riccardo. Trace Elemental 

Determination in Residual 

Fuel Oils Using ICP-MS. Applications 

of ICP & ICP-MS Techniques 

for Today’s Spectroscopists, 


Mark, Howard; and Brown, Steve. 

Milestones in Spectroscopy. June, 

p. 34. 

Mark, Howard; and Workman, Jerome. 

“Classical Least Squares, 

Part I: Mathematical Theory,” in 

Chemometrics in Spectroscopy. 

May, p. 16. 



Part II: Mathematical Theory 

Continued,” in Chemometrics in 

Spectroscopy. June, p. 20. 



Part III: Spectroscopic Theory,” 

in Chemometrics in Spectroscopy. 

October, p. 22. 

Mark, Howard. Pittcon 2010 New 

Product Review. May, p. 32. 

Martin, John E.; Anderson Smith, 

Lea L.; Adjei-Bekoe, Gloria; and 

Thomas, Robert. Comparison 

of Different Sample Preparation 

Procedures for the Determination 

of RoHS/WEEE Regulated Elements 

in Printed Circuit Boards 

and Electrical Components by 

EDXRF. April, p. 40. 

McCurdy, Ed; Sugiyama, Naoki; and 

Wilbur, Steven M. Optimizing 

Performance for a Collision/Reaction 

Cell ICP-MS System Operating 

in Helium Collision Mode. 

Applications of ICP & ICP-MS 

Techniques for Today’s Spectroscopists, 


McCurdy, Ed. See Wilbur, Steven M. 

McDonald, Stephen. See Yu, Kate. 

McDowall, R.D. “Dear Esteemed 

Vendor?” in Focus on Quality. 


McDowall, R.D. “Fat Finger, Falsification, 

or Fraud?” in Focus on 

Quality. December, p. 15. 

McDowall, R.D. “Understanding 

and Interpreting the GAMP 5 

Life Cycle Models for Software,” 

in Focus on Quality. April, p. 22. 

McDowall, R.D. “Where Are We 

Now with USP ?” in Focus 

on Quality. November, p. 24. 

McGinley, Michael; and Sanchez, 

Carl. Development of a High- 

Throughput LC–MS Assay for 

Drugs of Abuse from Biological 

Matrices. Current Trends in Mass 


McGinley, Michael; and Sanchez, 

Carl. Translating HPLC Performance 

Gains of Core-Shell Media 

to LC–MS Applications. Current 


May, p. 36. 

McSheehy, Shona. See Hamester, 

Meike. 

Millar, Alan. See Yu, Kate. 

Morphet, James. See Jenkins, Tim J. 

Morris, Robert. “How Optical Advances 

Helped Deliver the Promise 

of Miniature Spectrometers,” 

in Laser and Optics Interface. 


Muccio, Zeland. See Baum, Andreas. 

Murdock, Justin N.; Dodds, Walter 

K.; Reffner, John A.; and Wetzel, 

David L. Measuring Cellular- 

Scale Nutrient Distribution in 

Algal Biofilms with Synchrotron 

Confocal Infrared Microspectroscopy. 


Murphy, Brian. See Yu, Kate. 

N 

Narayanaswamy, Sivakumar. Spectroscopy 

Market: Weathering the 

Storm and on the Path to Recovery. 


Neubauer, Kenneth. “Reducing the 

Effects of Interferences in Quadrupole 

ICP-MS,” in Atomic Perspectives. 


O 

Obenauf, Ralph. See Atkins, Patricia. 

Oki, Tomoko; Wills, Julian D.; 

McSheehy, Shona; Hamester, 

Meike; Lindemann, Torsten; 

and Hinrichs, Joachim. Direct, 

Automated Analysis of Organic 

Solvents Using Quadrupole ICP- 

MS Coupled with a Dual Syringe 

Pump Sample System. Applications 

of ICP & ICP-MS Techniques 

for Today’s Spectroscopists, November, 

p. 6. 

Oppermann, Uwe; and Schram, Jürgen. 

Interference-Free Drinking 

Water Analysis Using ICP-OES. 

Applications of ICP & ICP-MS 

Techniques for Today’s Spectroscopists, 


Ortelli, Didier. See Jenkins, Tim J. 

P 

Pace, Nadia. See Schreiber, André. 

Pamuku, Matt. See Rahman, G. M. 

Mizanur. 

Pettigrew, William. See Rodgers, 

James. 

Plumb, Robert S.; Rainville, Paul 

D.; and Evans, Christopher A. 

Bioanalysis Using Dried Blood 

Spots: The Biggest Advancement 

in Bioanalysis Since LC–MS-MS? 


July, p. 22. 

R 

Rahman, G.M. Mizanur; Fahrenholz, 

Timothy M.; Kingston, H. 

M. Skip; Pamuku, Matt; Hwang, 

J. David; and Young, Lyman A. 

Speciation of Mercury in Crude 

Oil Using Speciated Isotope Dilution 

Mass Spectrometry. January, 

p. 36. 

Rainville, Paul D. See Plumb, Robert 

S. 

Ramagiri, Suma. See Ghobarah, 

Hesham. 

Reffner, John A. See Murdock, Justin N. 

Reffner, John; Smith, Shay; and 

Adar, Fran. Characterizing Colored 

Fibers by FT-IR and Raman 

Spectroscopy. FT-IR Technology 

for Today’s Spectroscopists, August, 

p. 6. 

Roberts, Gareth M. The Use of Novel 

Software for the Identification of 

Trace Compounds in Complex 

Mixtures. Current Trends in Mass 

Spectrometry, July, p. 16. 

Rodgers, James; Kang, Sho Yeung; Fortier, 

Chanel; Cui, Xiaoliang; Davidonis, 

Gayle; Clawson, Ernest; Boquet, 

Don; and Pettigrew, William. 

Preliminary Field Measurement of 

Cotton Fiber Micronaire by Portable 

NIR. September, p. 38. 

Rury, Maura. See Almeida, Manuel.


Y 

Yee, Ki-Ju. See Kim, Seung-Hyun. 

Yeung, Ken K.-C. See Zhang, Cunjie. 

Young, Lyman A. See Rahman, G. 

M. Mizanur. 

Yu, Kate; Millar, Alan; Shion, Henry; 

McDonald, Stephen; Goshawk, 

Jeff; and Murphy, Brian. Qualitative 

and Quantitative Metabowww.spectroscopyonline.com 

S 

Sanchez, Carl; Koerner, Philip J.; 

and Countryman, Sky. Development 

of a High-Throughput LC– 

MS-MS Assay for 13 Commonly 

Prescribed Pain Management 

Drugs from Urine with Cleanup 

Using Solid-Phase Extraction. 


July, p. 34. 

Sanchez, Carl. See McGinley, Michael. 

Sanders, Mark. See Zhang, Allen. 

Sandra, Pat. See Vanhoenacker, 

Gerd. 

Schanen, Pierre. See Gerhards, 

Petra. 

Schmid, Lawrence S. Spectroscopy 

Bounces Back. March, p. 40. 

Schmidt, U.; Jauss, A.; Dieing, T.; 

and Hollricher, O. Confocal 

Raman AFM Imaging of Paper. 



Schram, Jürgen. See Oppermann, 

Uwe. 

Schreiber, André; and Pace, Nadia. 

LC–MS-MS–Based Strategies for 

the Targeted and Nontargeted 

Screening of Contaminants 

in Food, Environmental, and 

Forensic Samples. Current Trends 

in Mass Spectrometry, March, 

p. 34. 

Sengupta, Atanu. See Drapcho, 

David. 

Shen, Yaochun. See Taday, Philip F. 

Shende, Chetan. See Drapcho, 

David. 

Shin, Hee-Sung. See Kim, Seung- 

Hyun. 

Shion, Henry. See Yu, Kate. 

Sivakumar, Vanaja. See Atkins, Patricia. 

Skilton, St John. See Ahn, Joomi. 

Smith, Philip A. See Lee, Edgar D. 

Smith, Shay. See Reffner, John. 

Sparkman, O. David; Curtis, Matthew; 

and Jones, Patrick R. Interaction 

of Dichloromethane 

Solvent with n-Alkylamines 

Analyzed by Electron Ionization 

GC–MS. Current Trends in Mass 

Spectrometry, March, p. 8. 

Staples, Doug. See Heim, John. 

Stevens, Joan; and Szelewski, Mike. 

Meeting the Surge in Demand for 

Seafood Screening on the Gulf 

Coast. Current Trends in Mass 


Sugiyama, Hiroshi. See Larsen, 

Richard A. 

Sugiyama, Naoki. See McCurdy, Ed. 

Szelewski, Mike. See Stevens, Joan. 

T 

Taday, Philip F.; Evans, Michael; 

Zeitler, Axel; Shen, Yaochun; and 

Dey, Dipankar. “Terahertz Technology: 

Moving from the Laboratory 

into the Process World,” 

in Laser and Optics Interface. 

April, p. 32. 

Tague Jr., Thomas J.; Leona, Marco; 

and Wang, Peng. Raman Spectroscopy 

of Documents. Defense 

and Homeland Security, April, 

p. 20. 

Thakur, Rohan A.; Koleto, Michael; 

Dong, Dahai; Begley, Benjamin; 

and Koetzner, Lee. Dried Blood 

Spots and High-Resolution Mass 

Spectrometry for Discovery Fast 

PK Bioanalysis. Current Trends 

in Mass Spectrometry, October, 

p. 14. 

Thakur, Rohan. A Study of Matrix 

Effects on Multiply Charged 

Compounds. Current Trends in 


Thomas, Robert. See Martin, John E. 

Thomsen, Volker; and Coutinho, 

Carlos Augusto. “Electron Transitions 

in Optical Emission and 

X-Ray Fluorescence Spectrometry,” 

in Atomic Perspectives. 

March, p. 30. 

Thomsen, Volker; and Coutinho, 

Carlos Augusto. Spectrometers 

for Elemental Spectrochemical 

Analysis, Part II: X-Ray Fluorescence 

Spectrometers. July, p. 38. 

Thomsen, Volker. Assessing Accuracy. 

February, p. 32. 

Thomsen, Volker. Spectrometers 

for Elemental Analysis, Part I: 

The Basic Spectrometer. January, 

p. 46. 

Thomsen, Volker. Spectrometers 

for Elemental Spectrochemical 

Analysis, Part III: Arc/Spark 

Optical Emission Spectrometers. 


Tripathi, Ashish. See Emmons, Erik D. 

Tsuchibuchi, Tsuyoshi. Handling 

Spectra from FT-IR Foreign Matter 

Analysis. FT-IR Technology for 

Today’s Spectroscopists, August, 

p. 16. 

V 

Vanhoenacker, Gerd; David, Frank; 

and Sandra, Pat. Ultralow Quantification 

of Pesticides in Baby 

Food. Current Trends in Mass 

Spectrometry, July, p. 10. 

W 

Waddell, Keith; and Gudihal, Ravindra. 

Comprehensive Characterization 

of Monoclonal Antibodies 

Using a Microfluidic Chip-Q- 

TOF Platform. Current Trends in 


Walsh, David. Spectroscopy Moves 

into the Digital Age. June, p. 42. 

Wang, Peng. See Tague Jr., Thomas J. 

Wetzel, David L. See Murdock, 

Justin N. 

White, Robert. See Macherone, 

Anthony. 

Wieboldt, Dick. Understanding 

Raman Spectrometer Parameters. 



Wilbur, Steven; and McCurdy, Ed. 

“Using Qualifier Ions to Validate 

Multielement ICP-MS Data 

in Complex Samples,” in Atomic 

Perspectives. May, p. 22. 

Wilbur, Steven M. See McCurdy, Ed. 

Wills, Julian D. See Oki, Tomoko. 

Workman, Jerome; and Mark, Howard. 

“Statistics and Chemometrics 

for Clinical Data Reporting, 

Part III: Using Excel for Data 

Plotting,” in Chemometrics in 

Spectroscopy. February, p. 24. 

Workman, Jerome. See Mark, 

Howard. 

Worrall, Keith. See Jenkins, Tim J.


lite Identification for Verapamil 

in Rat Plasma by Sub-2-μm LC 

Coupled with Quadrupole TOF- 

MS. Current Trends in Mass Spectrometry, 


Yu, Yingqing. See Ahn, Joomi. 

Z 

Zeitler, Axel. See Taday, Philip F. 

Zhang, Allen; Chang, James S.; Gu, 

Christine; and Sanders, Mark. 

Nontargeted Screening and Accurate 

Mass Confirmation of 

Pesticides Using High-Resolution 

LC–Orbital Trap Mass Spectrometry. 


July, p. 40. 

Zhang, Cunjie; Zhang, Haixia; Litchfield, 

David W.; and Yeung, 

Ken K.-C. CHCA or DHB? Systematic 

Comparison of the Two 

Most Commonly Used Matrices 

for Peptide Mass Fingerprint 

Analysis with MALDI-MS. February, 

p. 48. 

Zhang, Guangjun. See Li, Yaping. 

Zhang, Haixia. See Zhang, Cunjie. 

Zlatkin, Igor. See Drapcho, David. 

SUBJECTS 

ATOMIC PERSPECTIVES 

COLUMN 

“Atomic Absorption: Feeding the 

Food Safety Market,” in Atomic 

Perspectives. Hazel Dickson. July, 

p. 26. 

“Electron Transitions in Optical 

Emission and X-Ray Fluorescence 

Spectrometry,” in Atomic 

Perspectives. Volker Thomsen 

and Carlos Augusto Coutinho. 

March, p. 30. 

“Reducing the Effects of Interferences 

in Quadrupole ICP-MS,” 

in Atomic Perspectives. Kenneth 

Neubauer. November, p. 30. 


Multielement ICP-MS Data in 

Complex Samples,” in Atomic 

Perspectives. Steve Wilbur and 

Ed McCurdy. May, p. 22. 

ATOMIC SPECTROSCOPY 

“Atomic Absorption: Feeding the Food 

Safety Market,” in Atomic Perspectives. 

Hazel Dickson. July, p. 26. 






March, p. 30. 

A Quantitative Analysis of Neodymium 

and Samarium at Low Pressure 

by Laser-Induced Breakdown 

Spectroscopy. Seung-Hyun Kim, 

June-Sik Ju, Hee-Sung Shin, Ho- 

Dong Kim, and Ki-Ju Yee. November, 

p. 38. 





Spectrometers for Elemental Analysis, 

Part I: The Basic Spectrometer. 

Volker Thomsen. January, p. 46. 

Spectrometers for Elemental Spectrochemical 

Analysis, Part III: 

Arc/Spark Optical Emission 

Spectrometers. Volker Thomsen. 


Using ICP-OES for Accurate Monitoring 

of Metallic Contaminants 

in Water According to U.S. EPA 

Method 200.7. Matthew Cassap. 

May, p. 64. 




Perspectives. Steve Wilbur and 


BASELINE COLUMN 

“Group Theory and Symmetry, Part 

II: Groups,” in The Baseline. 

David W. Ball. January, p. 18. 


III: Representations and Character 

Tables,” in The Baseline. 

David W. Ball. April, p. 16. 


IV: Great or Grand, We've Got 

GOT,” in The Baseline. David W. 

Ball. September, p. 18. 

“Happy Sesquicentennial, Spectroscopy,” 

in The Baseline. David W. 

Ball. June, p. 16. 

“Neutron Spectroscopy,” in The Baseline. 

David Ball. December, p. 12. 

BIOLOGICAL AND MEDICAL 

ANALYSIS 

"Analysis of Lignin and Cellulose 

in Biological Energy Sources by 

Raman Microscopy,” in Molecular 

Spectroscopy Workbench. 

Fran Adar. February, p. 18. 

CHCA or DHB? Systematic Comparison 

of the Two Most Commonly 

Used Matrices for Peptide 

Mass Fingerprint Analysis 

with MALDI-MS. Cunjie Zhang, 

Haixia Zhang, David W. Litchfield, 

and Ken K.-C. Yeung. February, 

p. 48. 

Measuring Cellular-Scale Nutrient 

Distribution in Algal Biofilms 

with Synchrotron Confocal Infrared 

Microspectroscopy. Justin N. 

Murdock, Walter K. Dodds, John 

A. Reffner, and David L. Wetzel. 


Near-Infrared Spectrophotometric 

Analysis of Human Blood Glucose: 

Influence of Repeating Errors 

on Prediction Accuracy. Yaping 

Li, Qingbo Li, and Guangjun 

Zhang. June, p. 46. 

CHEMOMETRICS IN 

SPECTROSCOPY COLUMN 

“Classical Least Squares, Part I: Mathematical 

Theory,” in Chemometrics 

in Spectroscopy. Howard Mark and 

Jerome Workman. May, p. 16. 

“Classical Least Squares, Part II: 

Mathematical Theory Continued,” 


Howard Mark and Jerome 

Workman. June, p. 20. 

“Classical Least Squares, Part III: 

Spectroscopic Theory,” in Chemometrics 

in Spectroscopy. Howard 

Mark and Jerome Workman. 


“Statistics and Chemometrics for 

Clinical Data Reporting, Part III: 

Using Excel for Data Plotting,” in 


Jerome Workman and Howard 

Mark. February, p. 24. 

DATA ANALYSIS 

Assessing Accuracy. Volker Thomsen. 


“Classical Least Squares, Part I: 

Mathematical Theory,” in Chemometrics 

in Spectroscopy. 

Howard Mark and Jerome Workman. 

May, p. 16.













Differentiation Between Origins of 

Extra Virgin Olive Oils by GC– 

C-IRMS Using Principal Component 

Analysis, Linear Discriminant 

Analysis, and Hierarchical 

Cluster Analysis. Andreas Baum, 

Yao Lu, Zeland Muccio, Glen P. 

Jackson, and Peter B. Harrington. 


“Statistics and Chemometrics for 

Clinical Data Reporting, Part III: 

Using Excel for Data Plotting,” in 


Jerome Workman and Howard 

Mark. February, p. 24. 

FOCUS ON QUALITY COLUMN 

“Dear Esteemed Vendor?” in Focus 

on Quality. R.D. McDowall. September, 

p. 22. 

“Fat Finger, Falsification, or Fraud?” 

in Focus on Quality. R.D. Mc- 

Dowall. December, p. 15. 

“Understanding and Interpreting 

the GAMP 5 Life Cycle Models 

for Software,” in Focus on Quality. 

R.D. McDowall. April, p. 22. 

“Where Are We Now with USP 

?" in Focus on Quality. 

R.D. McDowall. November, p. 24. 

FOOD AND BEVERAGE 

ANALYSIS 










HISTORY 

“Happy Sesquicentennial, Spectroscopy,” 

in The Baseline. David W. 

Ball. June, p. 16. 

“Mass Spectrometry–Mass Spectrometry 

Retrospective,” in Mass 

Spectrometry Forum. Kenneth L. 

Busch. July, p. 14. 

Milestones in Spectroscopy. Howard 

Mark and Steve Brown. June, p. 

34. 



Volker Thomsen. January, 

p. 46. 

Spectroscopy Moves into the Digital 

Age. David Walsh. June, p. 42. 

Spectroscopy Uncensored: An Insider's 

Story of the First 15 Years. 

Michael MacRae. June, p. 26. 

HYPHENATED TECHNIQUES 










ICP AND ICP-MS 





Speciation of Mercury in Crude Oil 

Using Speciated Isotope Dilution 

Mass Spectrometry. G.M. Mizanur 

Rahman, Timothy M. Fahrenholz, 

H.M. Skip Kingston, Matt 

Pamuku, J. David Hwang, and 

Lyman A. Young. January, p. 36. 

Using ICP-OES for Accurate Monitoring 

of Metallic Contaminants 

in Water According to U.S. EPA 

Method 200.7. Matthew Cassap. 

May, p. 64. 




Perspectives. Steven Wilbur and 


IMAGING AND MICROSCOPY 

“Analysis of Lignin and Cellulose 





“CMOS Technology for Scientific 

Imaging,” in Laser and Optics 

Interface. Ken Kaufmann. July, 

p. 20. 

“Depth Resolution of the Raman Microscope: 

Optical Limitations and 

Sample Characteristics,” in Molecular 


Fran Adar. March, p. 16. 








INFRARED SPECTROSCOPY 








X-Ray Fluorescence and FT-IR Identification 

of Strontium and Carbonate 

in Domestic and Imported 

Gypsum Drywall. Jeffrey Hirsch, 

Steven R. Lowry, and Mick Dowd. 

July, p. 30. 

LASER AND OPTICS INTERFACE 

COLUMN 

“CMOS Technology for Scientific 

Imaging,” in Laser and Optics 

Interface. Ken Kaufmann. July, 

p. 20. 

“How Optical Advances Helped Deliver 

the Promise of Miniature 

Spectrometers,” in Laser and 

Optics Interface. Robert Morris. 


“Terahertz Technology: Moving 

from the Laboratory into the 

Process World,” in Laser and 

Optics Interface. Philip F. Taday, 

Michael Evans, Axel Zeitler, Yaochun 

Shen, and Dipankar Dey. 

April, p. 32. 

LASERS 

A Quantitative Analysis of Neodymium 

and Samarium at Low 

Pressure by Laser-Induced Breakdown 

Spectroscopy. Seung-Hyun 

Kim, June-Sik Ju, Hee-Sung Shin,


Ho-Dong Kim, and Ki-Ju Yee. 


MARKET ANALYSIS 

Spectroscopy Bounces Back. Lawrence 

S. Schmid. March, p. 40. 

Spectroscopy Market: Weathering 

the Storm and on the Path to Recovery. 

Sivakumar Narayanaswamy. 


2010 Salary Survey: A Year of Pluses 

and Minuses. Megan Evans. 

March, p. 36. 

MASS SPECTROMETRY FORUM 

COLUMN 

“Derivatization in Mass Spectrometry,” 


Forum. Kenneth L. Busch. November, 

p. 18. 

“Ion Burn and the Dirt of Mass Spectrometry,” 


Forum. Kenneth L. Busch. September, 

p. 32. 

“Mass Spectral Libraries: The Next 

Generation,” in Mass Spectrometry 

Forum. Kenneth L. Busch. 






“A Random Walk Through the Web 

of Mass Spectrometry,” in Mass 


Busch. March, p. 24. 

MASS SPECTROMETRY 

CHCA or DHB? Systematic Comparison 

of the Two Most Commonly 

Used Matrices for Peptide 

Mass Fingerprint Analysis 

with MALDI-MS. Cunjie Zhang, 

Haixia Zhang, David W. Litchfield, 

and Ken K.-C. Yeung. February, 

p. 48. 

“Derivatization in Mass Spectrometry,” 


Forum. Kenneth L. Busch. November, 

p. 18. 










“Ion Burn and the Dirt of Mass Spectrometry,” 


Forum. Kenneth L. Busch. September, 

p. 32. 

“Mass Spectral Libraries: The Next 

Generation,” in Mass Spectrometry 

Forum. Kenneth L. Busch. 






“A Random Walk Through the Web 

of Mass Spectrometry,” in Mass 


Busch. March, p. 24. 

Speciation of Mercury in Crude Oil 

Using Speciated Isotope Dilution 

Mass Spectrometry. G.M. Mizanur 

Rahman, Timothy M. Fahrenholz, 

H.M. Skip Kingston, Matt 

Pamuku, J. David Hwang, and 

Lyman A. Young. January, p. 36. 

MEETING REPORTS 

Pittcon 2010 New Product Review. 

Howard Mark. May, p. 32. 

“Thoughts About ICORS 2010 and 

Where Raman Spectroscopy Is 

Headed,” in Molecular Spectroscopy 

Workbench. Fran Adar. October, 

p. 16. 

MOLECULAR SPECTROSCOPY 

WORKBENCH COLUMN 















p. 16. 

NEAR-IR SPECTROSCOPY 

Near-Infrared Spectrophotometric 

Analysis of Human Blood Glucose: 

Influence of Repeating Errors 

on Prediction Accuracy. Yaping 

Li, Qingbo Li, and Guangjun 

Zhang. June, p. 46. 

Preliminary Field Measurement 

of Cotton Fiber Micronaire by 

Portable NIR. James Rodgers, 

Sho Yeung Kang, Chanel Fortier, 

Xiaoliang Cui, Gayle Davidonis, 

Ernest Clawson, Don Boquet, and 

William Pettigrew. September, p. 

38. 

OPTICS 






“How Optical Advances Helped Deliver 

the Promise of Miniature 

Spectrometers,” in Laser and 

Optics Interface. Robert Morris. 


RAMAN SPECTROSCOPY 















p. 16. 

SAMPLE PREPARATION AND 

INTRODUCTION 

Comparison of Different Sample 

Preparation Procedures for the 

Determination of RoHS/WEEE 

Regulated Elements in Printed 

Circuit Boards and Electrical 

Components by EDXRF. John E. 

Martin, Lea L. Anderson Smith, 

Gloria Adjei-Bekoe, and Robert 

Thomas. April, p. 40. 

SPECTROSCOPIC THEORY 

“Classical Least Squares, Part I: 

Mathematical Theory,” in Chemometrics 

in Spectroscopy.



Howard Mark and Jerome Workman. 

May, p. 16. 
















March, p. 30. 


II: Groups,” in The Baseline. 

David W. Ball. January, p. 18. 


III: Representations and Character 

Tables,” in The Baseline. 

David W. Ball. April, p. 16. 


IV: Great or Grand, We've Got 

GOT,” in The Baseline. David W. 

Ball. September, p. 18. 




p. 46. 

SUPPLEMENT: APPLICATIONS 

OF ICP & ICP-MS 

TECHNIQUES FOR TODAY’S 

SPECTROSCOPISTS 

A Common Sense Laboratory Guide 

to Reducing Errors and Contamination 

in ICP and ICP-MS 

Analysis. Patricia Atkins, Laszlo 

Ernyei, Vanaja Sivakumar, and 

Ralph Obenauf. November, p. 42. 

Determination of Trace Elements in 

Over-the-Counter Cough Syrup 

by Inductively Coupled Plasma– 

Optical Emission Spectroscopy. 

Manuel Almeida, Maura Rury, 

John Condon, and Peter Brown. 


Direct, Automated Analysis of Organic 

Solvents Using Quadrupole 

ICP-MS Coupled with a Dual Syringe 

Pump Sample System. Tomoko 

Oki, Julian D. Wills, Shona 

McSheehy, Meike Hamester, Torsten 

Lindemann, and Joachim 

Hinrichs. November, p. 6. 

Interference-Free Drinking Water 

Analysis Using ICP-OES. Uwe 

Oppermann and Jürgen Schram. 


Optimizing Performance for a Collision/Reaction 

Cell ICP-MS System 

Operating in Helium Collision 

Mode. Ed McCurdy, Naoki 

Sugiyama, and Steven M. Wilbur. 


Trace Elemental Determination in 

Residual Fuel Oils Using ICP- 

MS. Riccardo Magarini. November, 

p. 30. 

SUPPLEMENT: DEFENSE AND 

HOMELAND SECURITY 

Handheld FT-IR and Raman as 

Tools in the Analysis of Improvised 

Explosive Materials. Robert 

L. Green, Michael D. Hargreaves, 

and Christopher D. Brown. April, 

p. 14. 

Laser-Based Technologies Target 

Terrorists. Jason Eichenholz, 

Kevin Kaye, and Steve Buckley. 

April, p. 26. 

Raman Chemical Imaging of Explosive 

Contaminated Fingerprints 

for Forensic Applications. Erik D. 

Emmons, Ashish Tripathi, Jason 

A. Guicheteau, Steven D. Christesen, 

and Augustus W. Fountain 

III. April, p. 8. 

Raman Spectroscopy of Documents. 

Thomas J. Tague Jr., Marco Leona, 

and Peng Wang. April, p. 20. 

Rapid Chemical Threat Identification 

by SPME-GC–TMS. Edgar 

D. Lee, Philip A. Smith, Christopher 

R. Bowerbank, and Douglas 

W. Later. April, p. 30. 

SUPPLEMENT: FT-IR 

TECHNOLOGY FOR TODAY’S 


Characterizing Colored Fibers by 

FT-IR and Raman Spectroscopy. 

John Reffner, Shay Smith, and 

Fran Adar. August, p. 6. 

Handling Spectra from FT-IR Foreign 

Matter Analysis. Tsuyoshi 

Tsuchibuchi. August, p. 16. 

Hollow Waveguides: The Next Generation 

of Mid-IR Remote Sampling 

Accessories. Jenni L. Briggs. 

August, p. 36. 

Improved FT-IR Instrumentation 

and Software for Complete Confidence 

in QA/QC Testing. Mike 

Bradley and Jeffrey Hirsch. August, 

p. 24. 

Using FT-IR Microscope ATR Objectives 

to Resolve Complex Samples. 

Richard A. Larsen, Ken-ichi 

Akao, Jun Koshoubu, and Hiroshi 

Sugiyama. August, p. 42. 

SUPPLEMENT: CURRENT 

TRENDS IN MASS 

SPECTROMETRY 

Advancing TOF-MS–Based Screening 

for Food Safety Residue Analysis 

with a Positive Approach. 

Tim J. Jenkins, Keith Worrall, 

Peter Hancock, James Morphet, 

Emmanuelle Cognard, and Didier 

Ortelli. March, p. 25. 

Analyzing Small Molecule Metabolite 

Profiles of Diabetic and Nondiabetic 

Urine Samples Using 

GC×GC–TOF-MS and Statistical 

Software as a Data Mining Strategy. 

John Heim. March, p. 30. 

Bioanalysis Using Dried Blood 

Spots: The Biggest Advancement 

in Bioanalysis Since LC–MS-MS? 

Robert S. Plumb, Paul D. Rainville, 

and Christopher A. Evans. 

July, p. 22. 

Branching Out: Mass Spectrometry 

and the Shape of Biotherapeutics. 

Joomi Ahn, Vera Ivleva, St John 

Skilton, and Yingqing Yu. May, 

p. 28. 

Comparing the Capabilities of 

Time-of-Flight and Quadrupole 

Mass Spectrometers. Joe Binkley, 

and Mark Libarondi. July, p. 28. 

Comprehensive Characterization of 

Monoclonal Antibodies Using a 

Microfluidic Chip-Q-TOF Platform. 

Keith Waddell, and Ravindra 

Gudihal. March, p. 15. 

Development of a High-Throughput 

LC–MS Assay for Drugs of Abuse 

from Biological Matrices. Michael 

McGinley and Carl Sanchez. October, 

p. 24. 

Development of a High-Throughput 

LC–MS-MS Assay for 13 

Commonly Prescribed Pain


Management Drugs from Urine 

with Cleanup Using Solid-Phase 

Extraction. Carl Sanchez, Philip 

J. Koerner, and Sky Countryman. 

July, p. 34. 

Dried Blood Spots and High-Resolution 

Mass Spectrometry for Discovery 

Fast PK Bioanalysis. Rohan 

A. Thakur, Michael Koleto, Dahai 

Dong, Benjamin Begley, and Lee 

Koetzner. October, p. 14. 

Enhancing Mass Spectral Formula 

Determination by Heuristic Rules. 

Ming Gu. May, p. 42. 

58th ASMS Conference Review. 

Megan Evans. July, p. 44. 

Increasing Productivity of ADME 

Studies Using Accurate Mass 

Technology. Hesham Ghobarah, 

Suma Ramagiri, and Jim Ferguson. 


Interaction of Dichloromethane 

Solvent with n-Alkylamines Analyzed 

by Electron Ionization 

GC–MS. O. David Sparkman, 

Matthew Curtis, and Patrick R. 

Jones. March, p. 8. 

LC–MS-MS–Based Strategies for the 

Targeted and Nontargeted Screening 

of Contaminants in Food, Environmental, 

and Forensic Samples. 

André Schreiber and Nadia 

Pace. March, p. 34. 

Meeting the Surge in Demand for 

Seafood Screening on the Gulf 

Coast. Joan Stevens and Mike 

Szelewski. October, p. 8. 

Nontargeted Screening and Accurate 

Mass Confirmation of Pesticides 

Using High-Resolution LC–Orbital 

Trap Mass Spectrometry. 

Allen Zhang, James S. Chang, 

Christine Gu, and Mark Sanders. 

July, p. 40. 

Phosphorylation Site Localization 

Using Probability-Based Scoring. 

Steven P. Gygi. October, p. 28. 

Qualitative and Quantitative Metabolite 

Identification for Verapamil 

in Rat Plasma by Sub-2-μm LC 

Coupled with Quadrupole TOF- 

MS. Kate Yu, Alan Millar, Henry 

Shion, Stephen McDonald, Jeff 

Goshawk, and Brian Murphy. October, 

p. 32. 

Reliable and Efficient Sulfur Detection 

in Proteins Using ICP-MS 

with Capillary LC. Meike Hamester, 

Shona McSheehy, Daniel J. 

Kutscher, Tobias Konz, and Jörg 

Bettmer. October, p. 21. 

A Study of Matrix Effects on Multiply 

Charged Compounds. Rohan 

Thakur. March, p. 21. 

TOF-MS: A Viable Solution for 

Crude Oil Extract Analysis. Nick 

Bukowski. May, p. 22. 

Translating HPLC Performance 

Gains of Core-Shell Media to LC– 

MS Applications. Michael McGinley 

and Carl Sanchez. May, p. 36. 

Ultralow Detection of Estrogenic 

Compounds by GC–NCI-MS- 

MS. Anthony Macherone, Melissa 

Churley, and Robert White. May, 

p. 10. 

Ultralow Quantification of Pesticides 

in Baby Food. Gerd Vanhoenacker, 

Frank David, and Pat 

Sandra. July, p. 10. 

The Use of Novel Software for the 

Identification of Trace Compounds 

in Complex Mixtures. 

Gareth M. Roberts. July, p. 16. 

Using Comprehensive GC×GC– 

TOF-MS for Enhanced Detection 

and Separation in Antidoping 

Control Screening. John Heim 

and Doug Staples. May, p. 16. 

Using Novel TOF-MS to Increase 

Sensitivity and Confidently Detect 

Drugs of Abuse in Urine. 

Petra Gerhards, Pierre Schanen, 

and Gerhard Horner. October, p. 

18. 

SUPPLEMENT: RAMAN 

TECHNOLOGY FOR TODAY’S 


Confocal Raman AFM Imaging of 

Paper. U. Schmidt, A. Jauss, T. 

Dieing, and O. Hollricher. June, 

p. 32. 

High-Throughput Trace Analysis 

Using SERS-Active Microtiter 

Plates with a Raman Plate Reader. 

David Drapcho, Igor Zlatkin, 

Frank Inscore, Chetan Shende, 

Atanu Sengupta, Hermes Huang, 

and Stuart Farquharson. June, 

p. 42. 

Low-Resolution Raman Spectroscopy 

in Science Education. Jorge 

Macho. June, p. 12. 

Transmission Raman: A Method 

for Quantifying Bulk Materials. 

Eunah Lee and Fran Adar. 

June, p. 6. 

Understanding Raman Spectrometer 

Parameters. Dick Wieboldt. June, 

p. 20. 

TUTORIALS 




p. 46. 


Analysis, Part II: 

X-Ray Fluorescence Spectrometers. 

Volker Thomsen and Carlos 

Augusto Coutinho. July, p. 38. 


Analysis, Part III: 

Arc/Spark Optical Emission Spectrometers. 

Volker Thomsen. October, 

p. 42. 

X-RAY SPECTROSCOPY 

Comparison of Different Sample 

Preparation Procedures for the 

Determination of RoHS/WEEE 

Regulated Elements in Printed 

Circuit Boards and Electrical 

Components by EDXRF. John E. 

Martin, Lea L. Anderson Smith, 

Gloria Adjei-Bekoe, and Robert 

Thomas. April, p. 40. 






March, p. 30. 


Analysis, Part II: 

X-Ray Fluorescence Spectrometers. 

Volker Thomsen and Carlos 

Augusto Coutinho. July, p. 38. 

X-Ray Fluorescence and FT-IR Identification 

of Strontium and Carbonate 

in Domestic and Imported 

Gypsum Drywall. Jeffrey Hirsch, 

Steven R. Lowry, and Mick Dowd. 

July, p. 30. 



www.spectroscopyonline.com

32 SPECTROSCOPY CORPORATE CAPABILITIES DECEMBER 2010 

A2 Technologies 



14 Commerce Drive 

Danbury, Connecticut 06810 

TELEPHONE 

(203) 312-1100 

FAX 

(203) 312-1058 

E-MAIL 

info@a2technologies.com 

WEB SITE 

www.a2technologies.com 

NUMBER OF EMPLOYEES 

USA: 26 

Elsewhere: 3 

YEAR FOUNDED 

2007 

Company Description 

A2 Technologies develops, manufactures, and markets miniaturized, 

hand held, portable, and benchtop high performance 

FTIR spectrometers and FTIR analyzers. Our customers are 

typically chemists, qc/qa personnel, engineers, spectroscopists, 

and analytical service personnel. A2’s products are used in a 

broad range of industries and applications such as aerospace, 

power generation, industrial qa/qc, as well as in academia. 

A2’s principal owners pioneered out-of-laboratory FTIR measurements 

and today we continue to focus on bringing FTIR 

to more and more diverse applications and end users. Our 

systems are designed to enable experienced FTIR users to develop 

dedicated methods, and then for those methods to be 

deployed with our analyzers in out-of-lab environments. 

Chief Spectroscopic Techniques Supported 

⦁ FTIR 

Major Products/Services 

A2 Technologies products include: the ML spectrometer, a 

compact bench top FTIR spectrometer; the MLp, a portable 

FTIR spectrometer for out-of-lab use; The PAL FTIR analyzer for 

measuring key components in oil, lubricating fluids, and fuels; 

Exoscan, the handheld FTIR spectrometer, which is designed 

to be used in the lab or at-site in the field and features interchangeable 

ATR, diffuse reflection, specular reflection, and 

grazing angle reflection sampling interfaces; and FlexScan, a 

handheld, portable FTIR analyzer for dedicated use in out-oflab 

sites. 

Facilities 

Headquartered in Danbury Connecticut, 

A2 Technologies is ISO compliant and has 

a direct sales force in the U.S. Our international 

sales office is located in the UK and 

we have an extensive group of world-wide 

distributors.


ABB Analytical Measurement 


ABB Analytical 

Measurement 

585 boul. Charest E. 

suite 300 

Quebec, QC 

G1K 9H4 

Canada 

TELEPHONE 

(418) 877-2944 

FAX 

(418) 877-2834 

E-MAIL 

ftir@ca.abb.com 

WEB SITE 

www.abb.com/analytical 


200 

YEAR FOUNDED 

1973 


Founded in 1973 as Bomem Inc., the Analytical Measurement 

Business Unit of ABB enables scientists around the world to 

perform through excellence in infrared spectroscopy. ABB is 

a market leader in Fourier Transform Infrared (FT-IR and FT- 

NIR) in terms of reliability and reproducibility. ABB Analytical 

designs, manufactures, and markets high-performance, affordable 

spectrometers as well as turnkey analytical solutions and 

spectroradiometers for remote sensing. ABB Analytical capabilities 

encompass one of the largest portfolios in the world for 

laboratory, at-line, and process FT-IR analyzers. They perform 

real-time analysis of the chemical composition and/or physical 

properties of a process sample stream. 


⦁ FT-IR 

⦁ FT-NIR 

⦁ Spectroradiometry and Remote Sensing 

⦁ Dedicated team of engineers offering simple and 

dependable solutions with reliable instruments 

⦁ Local point of contact for field service and technical 

support in most countries around the world with 

inventories for parts on all continents 

Markets Served 

⦁ Laboratory and Academic 

⦁ Life Sciences 

⦁ Pharmaceutical 

⦁ Fine Chemicals, Specialty Chemicals, and Commodity 

Chemicals 

⦁ Refining and Petrochemicals 

⦁ Metallurgical 

⦁ Semiconductor 

⦁ Original Equipment Manufacturer (OEM) 

⦁ Remote Sensing and Aerospace 


ABB’s advanced solutions combine 

analyzers, advanced process control, data 

management, and process and application 

knowledge to improve the operational performance, 

productivity, capacity, and safety 

of industrial processes for customers. For all 

laboratory or process needs, ABB can be 

your partner and single-source provider of 

simple, low-cost, high performance, general-purpose 

FT-IR and FT-NIR spectrometers. 

The company also markets analyzers 

for hydrogen and inclusion 

measurement in liquid aluminum. 

Facility 

Our manufacturing facility located in 

Quebec City, Canada, employs more than 

200 people, including R&D, manufacturing, 

marketing, sales, and administrative 

groups. The ABB Group of companies 

operates in around 100 countries and 

employs about 117,000 people.

HERO 

N 0 412 

David, senior automation engineer. 

A single FT-IR / NIR solution he trusts. 

FT-IR Optimizing Productivity. David oversees the quality analysis of recycled 

materials used by a multinational chemical company in its manufacturing 

process. Responsible for a multi-site environment, David appreciates that 

ABB FT-IR and FT-NIR spectrometers deliver proven calibration transfer without 

adjustment. As he and his company are committed to a sustainable environment, 

David also appreciates that ABB spectrometers ensure consistent, high-quality 

products while eliminating the use of chemical agents. Learn how ABB Analytical 

helped David overcome technical challenges at www.abb.com/analytical 

ABB Analytical 

Phone: +1 418-877-2944 

1 800 858-3847 (North America) 

E-mail: ftir@ca.abb.com


Amptek, Inc. 


Amptek, Inc. 

14 DeAngelo Drive 

Bedford, MA 01730 

TELEPHONE 

(781) 275-2242 

FAX 

(781) 275-3470 

E-MAIL 

sales@amptek.com 

WEB SITE 

www.amptek.com 


29 

YEAR FOUNDED 

1977 


Amptek, Inc. is a recognized world leader in the design and 

manufacture of state-of-the-art X-ray and gamma ray detectors, 

preamplifiers, instrumentation, and components for portable 

instruments, laboratories, satellites, and analytical purposes. 

These products provide the user with high performance and 

high reliability together with small size and low power. 


⦁ X-ray fluorescence (EDXRF) 

⦁ Direct spectral measurements 

⦁ SEM 

⦁ PIXE 

⦁ TXRF 


Amptek serves wherever X-ray detection is used; for example, 

hand-held and table-top XRF analyzers produced by OEMs; 

research facilities in universities, commercial enterprises, and 

the military; nuclear medicine; space; museums; environmental 

monitoring; and geological analysis of soils and minerals. 


Models XR-100CR and Super XR-100SDD are high-performance 

X-ray detector systems using a thermoelectric cooler 

and no liquid nitrogen, featuring a wide range of detection 

areas and efficiency and resolution of 127 eV FWHM. 

Power and shaping are provided by the PX4 Digital Pulse 

Processor. The XR-100 successfully analyzed the rocks and 

soil on Mars. 

The X-123 is a complete X-ray detector system in one 

small box that fits in your hand. The X-123 incorporates 

either the Amptek Si-Pin Diode Detector or Super Silicon 

Drift Detector; Charge Sensitive Preamplifier; the Amptek 

DP5 Digital Pulse Processor and MCA; and the Amptek PC5 

Power Supply. This small, low power, 

easy to operate, high-performance instrument 

is ideal for both the laboratory 

and OEM industries. 

Completing Amptek’s XRF portable 

solutions for exact measurements are 

the new, USB controlled Mini-X X-ray 

tube and the XRF-FP quantitative analysis 

software. Please visit our web site for 

complete specifications. 

Applications 

⦁ X-Ray Fluorescence 

⦁ Process Control 

⦁ OEM Instrumentation 

⦁ RoHS/WEEE Compliance Testing 

⦁ Nondestructive Analysis with XRF 

⦁ Restricted Metals Detection 

⦁ Environmental Monitoring 

⦁ Medical and Nuclear Electronics 

⦁ Heavy Metals in Plastics 

⦁ Lead Detectors 

⦁ Toxic Dump Site Monitoring 

⦁ Semiconductor Processing 

⦁ Nuclear Safeguards Verification 

⦁ Plastic & Metal Separation 

⦁ Coal & Mining Operations 

⦁ Sulfur in Oil and Coal Detection 

⦁ Smoke Stack Analysis 

⦁ Plating Thickness 

⦁ Oil Logging 

⦁ Electro-Optical Systems 

⦁ Research Experiments & Teaching 

⦁ Art and Archaeology 

⦁ Jewelry Analysis

X-Ray Detectors 

• No Liquid Nitrogen • USB Controlled 

• Low Cost 

• Easy to Use 

Complete XRF System 

PROVEN PERFORMANCE 

NEW SUPER SDD 

5.9 

keV 

127 eV FWHM 

25 mm 2 x 500 Mm 

11.2 Ms peaking time 

P/B Ratio: 8000/1 

55 

Fe 

Energy (keV) 

Complete X-Ray Spectrometer 

INCLUDES 

1 X-Ray Detector and Preamplifier 

2 Digital Pulse Processor and MCA 

3 Power Supply 

Counts 

Si-PIN 

149 eV FWHM 

6 mm 2 x 500 Mm 

25.6 Ms peaking time 

P/B Ratio: 6200/1 

5.9 

keV 

55 

Fe 

Energy (keV) 

OEM Components for XRF 

PA-210 Preamplifier 

inside optional 

heat sink 

AXR X-Ray 

Detector 

DP5 Digital 

Pulse Processor, 

Pulse Shaping, 

+ MCA 

PC5 Power 

Supply 

APPLICATIONS 

• OEM 

• X-Ray Fluorescence 

• RoHS-WEEE Compliance Testing 

• Process Control 

• Restricted Metals Detection 

• Heavy Metals in Plastic 

• Lead Detectors 

• Environmental Monitoring 

• Art & Archaeology 

• Jewelry Analysis 

• Plating Thickness 

Our OEM Technology 

Your Products 

• Table-top XRF Analyzers 

• Hand-held XRF Analyzers 

AMPTEK Inc. 

www.amptek.com


Applied Photophysics 


Applied Photophysics 

21 Mole Business Park 

Leatherhead 

Surrey KT22 7AG 

United Kingdom 

TELEPHONE 

+44 (0) 1372 386537 

Toll-free (from USA only) 

1-800 543 4130 

E-MAIL 

Sales Department: sales@ 

photophysics.com 

Technical Support: techsup@ 

photophysics.com 

WEB SITE 

www.photophysics.com 

YEAR FOUNDED 

1971 


Applied Photophysics is a world-leading manufacturer and 

supplier of precision spectrometers to researchers working 

in pharmaceutical, biotechnology, and academic environments. 

Our instruments are used to determine structural, 

thermodynamic, and kinetics properties of a wide range of 

samples in solution. Established in 1971, Applied Photophysics 

has an enviable reputation for outstanding performance 

and innovative technology. 


⦁ Circular Dichroism (CD) spectroscopy 

⦁ Stopped-flow spectroscopy 

⦁ Laser-flash spectroscopy 


Applied Photophysics offers precision spectrometers to academic 

and industrial markets, The Chirascan spectrometers 

are now the CD instruments of choice in pharmaceutical 

and biotechnology markets for use in drug development, 

formulation testing, and quality control. The SX20 and 

LKS.60 spectrometers are established leaders for stoppedflow 

and laser-flash research in the academic market, addressing 

applications in protein structure, folding, and conformation, 

together with biomolecular reaction kinetics and 

the study of chemical reaction mechanisms. 


Chirascan , Chirascan -plus and Chirascan -plus ACD 

spectrometers (CD) 

Outstanding sensitivity, novel detection technology, powerful 

software and now automation combine to make these 

CD spectrometers the world’s most advanced. 

SX20 stopped-flow spectrometer 

The SX20 is the market-leading stopped-flow reaction analyser 

capable of measuring fast reactions with a minimum of 

material. 

LKS.60 nanosecond laser-flash photolysis 

spectrometer 

The LKS.60 offers unmatched sensitivity 

for single and multiwavelength kinetics 

of very short-lived species, such as free 

radicals and excited-state species. 

RX.2000 rapid-mixing stopped-flow 

unit 

Adds stopped-flow rapid reaction kinetics 

to any UV-visible spectrometer or fluorometer. 

Pro-Data software 

All our products use a common software 

suite giving cross-platform compatibility. 

Accessories 

With all products, a wide range of accessories 

is available to expand the system 

as research interests evolve. 

Customer Support 

Support is provided for the lifetime of 

the product and every instrument comes 

with a warranty of at least 12 months 

that can be easily extended. A worldclass 

service team is on hand for support 

and applications advice. 

Facilities 

Headquartered close to London, UK. See 

www.photophysics.com/agents.php for 

worldwide distribution network.


Avantes, Inc. 


Avantes, Inc. 

9769 W. 119th Ave, Suite 4 

Broomfield, CO 80021 

TELEPHONE 

(303) 410-8668 

FAX 

(303) 410-8669 

E-MAIL 

infoUSA@avantes.com 

WEB SITE 

www.avantes.com 


40 

YEAR FOUNDED 

1993 


Avantes is a leading innovator 

in the development and 

application of miniature 

spectrometers. Avantes 

continues to develop and 

introduce new instruments 

for fiber optic spectroscopy 

to meet our customer’s application 

needs. Avantes instruments 

and accessories 

are also deployed into a 

variety of OEM applications 

in a variety of industries in 

markets throughout the world. With more than 15 years of 

experience in fiber optic spectroscopy and thousands of instruments 

in the field, Avantes is eager to help our customers 

find their Solutions in Spectroscopy ® . 


⦁ UV/VIS/NIR Spectroscopy 

⦁ Process Control 

⦁ Absorbance/Transmittance/Reflectance 

⦁ Laser-Induced Breakdown Spectroscopy 

⦁ CIE Color Spectroscopy 

⦁ Portable Spectrometers 

⦁ Fluorescence Spectroscopy 

⦁ Custom Applications 

⦁ Irradiance 

⦁ Raman Spectroscopy 

⦁ OEM Application Development 


Avantes works with customers in a variety of markets, including 

chemical, biomedical, aerospace, semiconductor, 

gemological, paper, pharmaceutical, and food processing 

technology. Additionally, Avantes works with research organizations 

and universities, aiding in developing research, 

and teaching opportunities. Our OEM program is designed 

to work with our customers to identify needs and customize 

an Avantes’ spectroscopy solution based on our customer’s 

needs and Avantes technical experience. Avantes’ 

continued growth is based upon a commitment to 

providing exceptional technology and superb customer 

satisfaction. 


Low-cost, high-resolution, miniature fiber optic spectrometers: 

System solutions and OEM instruments for applications 

from 185 nm to 2,500 nm. 

Detector choices: PDA, CMOS, CCD, 

back-thinned CCD, and InGaAs. 

Optical benches with focal lengths of 45, 

50 or 75 mm: revolutionary new ultra-low 

straylight optimized optical bench (ULS) 

and a new high sensitivity optical bench. 

Other features: 14 and 16 bit A/D converters, 

TE cooling, multi-channel instrument 

configurations enabling simultaneous 

signal acquisition, USB2 communication, 

support for multiple instruments from a 

single computer, and 14 programmable 

digital I/O ports. 

Standard Application Solutions: 

Irradiance and LED measurements, gemology, 

chemometric analysis, thin-film 

measurement, color, fluorescence, laserinduced 

breakdown spectroscopy, Raman 

spectroscopy, and process control. 

Light Sources: 

Tungsten-halogen, deuterium, LED, xenon, 

calibration sources for wavelength, and 

irradiance. 

Spectroscopy Accessories: 

Standard and custom fiber optic cables 

and probes, integrating spheres, cuvette 

holders, flow cells, collimating lenses, cosine 

correctors, vacuum feedthroughs, and 

fiber optic multiplexer. 

Facilities 

Avantes engineering manufacturing, sales, 

and service headquarters is in the Netherlands. 

The company also operates direct 

offices in China and North America. In addition, 

Avantes has a growing worldwide 

distribution network of more than 35 

qualified distributors to meet our customer’s 

needs worldwide.

www.spectroscopyonline.com DECEMBER 2010 SPECTROSCOPY CORPORATE CAPABILITIES 41 

B&W Tek, Inc. 

⦁ Lab Grade & Field Portable Raman 

Systems 

⦁ Customized design & development 

services 

⦁ Customized photonic instrumentation 

manufacturing 

Facilities 

B&W Tek, Inc. has 3 facilities in the 

United States, and 4 facilities in various 

international locations. 


B&W Tek, Inc. is an advanced instrumentation company 

producing optical spectroscopy and laser instrumentation 

for biomedical, physical, chemical, and research communities. 

With a strong vertical integration capability, B&W Tek, 

Inc. also provides custom product development, design, and 

manufacturing. 

B&W Tek, Inc. 

19 Shea Way 

Newark, DE 19713 

TELEPHONE 

(302) 368-7824 

FAX 

(302) 368-7830 

E-MAIL 

sales@bwtek.com 

WEB SITE 

www.bwtek.com 


USA: 80 

Elsewhere: 100 

YEAR FOUNDED 

1997 


⦁ UV 

⦁ Visible 

⦁ NIR 

⦁ Raman 

⦁ Laser 

⦁ Microscopy 


B&W Tek, Inc. provides solutions for analytical, industrial, 

medical, biophotonic, and diagnostic applications. The 

markets we serve include: universities, research labs, 

industries, oil and refining facilities, paper production, 

optical products manufacturers, drug and agricultural, 

health care, process analysis, and gemological research 

and development. 


⦁ Fiber Coupled Spectrometer Modules 

⦁ DPSS Lasers


BaySpec, Inc. 


BaySpec, Inc. 

1101 McKay Drive, 

San Jose, CA 95131 

TELEPHONE 

(408) 512-5928 

FAX 

(408) 512-5929 

E-MAIL 

sales@bayspec.com 

WEB SITE 

www.bayspec.com 


USA: 50-100 

YEAR FOUNDED 

1999 


BaySpec, Inc., founded in 1999 with 100% manufacturing in 

the USA (San Jose, California), is a vertically integrated spectral 

sensing company. The company designs, manufactures, 

and markets advanced spectral instruments, from UV-VIS-NIR 

spectrometers to handheld and portable NIR and Raman 

analyzers for a diverse customer base around the world. 

The telecommunication market “boom and bust” has produced 

an array of components and technologies, which collectively 

for the first time in instrumentation history, realized 

the dream of a low-cost yet highly accurate spectral device. 

Out of the ashes comes new growth. Stemming from Bay- 

Spec’s revolutionary Volume Phase Gratings (VPG ® ) -based 

telecom modules, customers in optical test & measurement, 

fiber sensing, UV-VIS-NIR and Raman spectroscopy, are benefiting 

and building innovative systems to meet the world’s 

most current optical system challenges. 

While our customer base already spans from the traditional 

areas of optical telecommunication and NIR spectroscopy, 

we are changing and revolutionizing the way of Raman, Fluorescence, 

absorption/reflection, handheld, and OCT spectroscopic 

instruments are applied. 


⦁ UV-VIS-NIR spectroscopy 

⦁ Raman spectroscopy 


⦁ Biomedical 

⦁ Pharmaceuticals 

⦁ Chemical 

⦁ Food 


⦁ Industrial controls 

⦁ Homeland security 

⦁ Fiber sensing 

⦁ Optical telecommunications 


⦁ The SuperGamut spectrometer series 

employ high efficiency volume phase 

grating (VPG) as the spectral dispersion 

element and high sensitivity detector 

arrays. Customized wavelength ranges 

are available from 190–2500 nm. 

⦁ BaySpec’s Raman products include 

OEM spectrographs, narrowband light 

sources, deep-cooled detector arrays, 

and wavelength optimized probes. 

Raman MicroSpectroscopy offerings include 

the Nomadic 3-wavelength (532, 

785, 1064 nm) microscope and the 

cost-effective MovingLab portable Raman 

microscope. 

⦁ UV-VIS-NIR spectrographs and spectrometers 

⦁ Handheld/Portable/Benchtop Raman 

Instruments 

⦁ Narrowband and Wideband Light 

Sources 

⦁ Fiber Optic Probes 

⦁ Fiber Optic Accessories 

⦁ Raman microscopes 

⦁ Hyperspectral imaging 

Facilities 

48,000 sq. ft,. facility in San Jose, California 

(Silicon Valley).


Bruker Corporation 

⦁ Electron paramagnetic resonance 

(EPR) 

⦁ Magnetic resonance imaging (MRI) 

⦁ Low resolution benchtop NMR 

analyzers 

⦁ X-ray crystallography (SC-XRD) 

⦁ X-ray diffraction (XRD) 

⦁ X-ray fluorescence (XRF) 

⦁ Handheld X-ray (XRF) spectrometers 

⦁ X-ray microanalysis (EDS, EBSD) 

⦁ Optical emission spectroscopy (OES) 

⦁ CS/ONH-Analysis 

⦁ Atomic force microscopy (AFM) 

⦁ Scanning probe microscopy (SPM) 

⦁ Stylus and optical metrology 

Bruker Corporation 

40 Manning Road 

Billerica, MA 01821 

TELEPHONE 

(978) 663-3660 

FAX 

(978) 667-5993 

E-MAIL 

info@bruker.com 

WEB SITE 

www.bruker.com 


The Bruker name has become synonymous with the excellence, 

innovation, and quality that characterizes our comprehensive 

range of scientific instrumentation. Our solutions 

encompass a wide number of analytical techniques ranging 

from magnetic resonance to mass spectrometry, to optical 

and X-ray spectroscopy. 

These market- and technology-leading products are driving 

and facilitating many key application areas such as life 

science research, pharmaceutical analysis, applied analytical 

chemistry applications, materials research and nanotechnology, 

clinical research, molecular diagnostics, and homeland 

defense. 

Visit our website to discover more about our technologies 

and solutions. 

Bruker — Innovation with Integrity! 


⦁ FT-infrared spectroscopy and microscopy (FT-IR) 

⦁ FT-near infrared spectroscopy (FT-NIR) 

⦁ Raman spectroscopy and microscopy 

⦁ Terahertz spectroscopy and imaging 

⦁ Liquid chromatography–mass spectrometry (LC–MS) 

⦁ FT-mass spectrometry (FTMS) 

⦁ MALDI-TOF (/TOF) mass spectrometry 

⦁ Inductively coupled plasma mass spectrometry (ICP-MS) 

⦁ Gas chromatography–mass spectrometry (GC–MS) 

⦁ Ion mobility spectrometry (OMS) 

⦁ Nuclear magnetic resonance (NMR)


CVI Melles Griot 


CVI Melles Griot Lasers 

2051 Palomar Airport Road, 200 

Carlsbad, CA 92011 

TELEPHONE 

(760) 438-2131 

E-MAIL 

lasers@cvimellesgriot.com 

CVI Melles Griot 

Optics & Assemblies: 

200 Dorado Place SE 

Albuquerque, NM 87123 

TELEPHONE 

(505) 296-9541 

E-MAIL 

optics@cvimellesgriot.com 

WEB SITE 

www.cvimellesgriot.com 

ASIA 

+81 3 3407-3614 

EUROPE 

+31 316 333 041 

Company 

Description 

CVI Melles Griot is a 

leading global supplier of 

OEM and fast turn catalog 

photonics products 

including lasers at over 

38 wavelengths, optics, 

coatings covering the 

deep ultraviolet to the 

infrared, opto-mechanics, 

and positioning equip- 

ment. The company’s unique breadth of manufacturing and 

design expertise in electronics, lasers, optics, coatings, and 

thermal management is evident in everything from simple 

components to precision integrated electro-optic assemblies. 


⦁ Spectroscopy; Microscopy 

⦁ Capillary electrophoresis 

⦁ Biotech/Medical 

⦁ Laser-induced fluorescence 


⦁ Particle characterization 


⦁ Non-contact inspection 

⦁ Industrial 

⦁ Interferometry 

⦁ Environmental 

⦁ Velocimetry 

⦁ Government/Military 


⦁ Design, development, and manufacturing on 3 continents 

⦁ Lasers, optics, thin films, mechanics, drive electronics 

⦁ Over 39 years of volume production 

⦁ Over 2.9 million lasers and 120 million optics shipped 

⦁


Energetiq Technology, Inc. 


UV-vis, broadband 

⦁ Ultra-high brightness, long-life, LDLS 

Laser-Driven Light Sources: 

EQ-99 (compact, economical, high 

brightness) 

EQ-1000 (high power, high brightness) 

EQ-1500/1510 (extreme high brightness) 

Energetiq Technology, Inc. 

7 Constitution Way 

Woburn, MA 01801 

TELEPHONE 

(781) 939-0763 

FAX 

(781) 939-0769 

E-MAIL 

info@energetiq.com 

WEB SITE 

www.energetiq.com 

YEAR FOUNDED 

2004 


Energetiq Technology is a developer and manufacturer of 

ultrahigh-brightness light sources that enable the manufacture 

and analysis of nano-scale structures and products. Used 

in complex scientific and engineering applications such as 

analytical instrumentation and leading edge semiconductor 

manufacture, Energetiq’s light products are based on new 

technology that features broadband output from 170 nm in 

the deep UV, through visible and into the infrared. 

Energetiq was founded in 2004 by an experienced technology 

development team with deep understanding of the high 

power plasma physics needed for high performance light 

products. This expertise enables Energetiq to provide light 

sources with the highest levels of brightness, performance, 

and reliability as well as long operating life. 


⦁ UV-vis spectrometry 

⦁ Soft X-ray microscopy 

⦁ Circular dichroism spectroscopy 

⦁ High performance liquid chromatography (HPLC) 

⦁ Water-window microscopy 


Energetiq’s light sources are used for: analytical spectroscopy, 

microscopy, and biological imaging in the life-sciences; 

lithography, metrology, inspection, resist and thin-film processing 

of semiconductors, displays, and storage devices; soft 

X-ray microscopy; and a variety of R&D applications where traditional 

arc-lamps and synchrotron radiation have commonly 

been used. 

Facilities 

Energetiq Technology provides local sales 

and service support through its technical 

staff in the Woburn, Massachusetts headquarters 

and representatives and distributors 

in Asia, ensuring quick turnaround for 

customers. In addition, the Massachusetts 

location has a clean manufacturing facility 

that provides Class 1000 assembly capability 

for optics assembly and manufacturing 

for LDLS products.


EDAX, Inc. 


EDAX, Inc. 

91 McKee Drive 

Mahwah, NJ 07430 

TELEPHONE 

(201) 529-4880 

FAX 

(201) 529-3156 

E-MAIL 

info.edax@ametek.com 

WEB SITE 

www.edax.com 

YEAR FOUNDED 

1962 


EDAX, Inc. is an ISO-9001 certified manufacturer with over 

45 years of experience building instrumentation for the 

elemental and structural analysis of materials. EDAX’s founding 

technology was the detection and measurement of 

fluorescent X-rays for qualitative and quantitative elemental 

analysis — for example, elemental analysis on electron beam 

microscopes. Since that time, EDAX has sought to expand 

our product offering through new technologies and complementary 

techniques to provide our customers with the latest 

analytical instrumentation available. EDAX continues to be 

the world leader in the X-ray microanalysis market while 

providing new products for micro X-ray fluorescence and 

electron backscatter diffraction. 


⦁ Energy Dispersive Spectroscopy 

⦁ Energy Dispersive X-ray Fluorescence 

⦁ Electron Back Scatter Diffraction 

⦁ Wavelength Dispersive Spectroscopy 


EDAX instrumentation for elemental and structural analysis 

is found in a broad spectrum of industrial, academic, and 

government applications from the field or warehouse to the 

most advanced research & development laboratory. Typical 

markets served include semiconductor and microelectronics, 

academic, and industrial R&D laboratories, 

ROHS/WEEE, renewable energy, 

pharmaceuticals, mining, security, forensics, 

catalysts, petrochemicals, metallurgy, 

and manufacturing operations. 


⦁ Energy Dispersive X-ray Fluorescence: 

EDAX manufactures micro XRF 

analyzers for the laboratory. 

⦁ Electron BackScatter Diffraction: 

EDAX supplies instrumentation for 

materials structural analysis on SEM 

electron-beam microscopes. 

⦁ Energy Dispersive Spectroscopy: 

EDAX provides a full range of EDS 

products for elemental analysis on 

SEM and TEM electron-beam microscopes. 

⦁ Wavelength Dispersive Spectroscopy: 

EDAX offers parallel beam WDS 

products for elemental analysis on 

SEM electron-beam microscopes. 

⦁ Fluorescent X-ray Detectors: EDAX supplies 

Si(Li) Detectors and Silicon Drift 

Detectors, which are capable of 

handling count rates of over 

1,000,000 cps and parallel beam 

wavelength dispersive spectrometers. 

Facilities 

EDAX headquarters is located in Mahwah, 

New Jersey, housing sales, technical 

support, and manufacturing operations. 

EDAX is committed to providing the best 

possible support for our customers worldwide 

with sales, service, and applications 

support offices located in Japan, China, 

Singapore, The Netherlands, Germany, 

UK, and the United States.

Orbis Puts a New Spin on 

Micro XRF Analysis Versatility 

Non-Destructive 

Micro to Millimeter 

Spot Elemental Analysis 

Using Primary Beam 

Filters on a Wide Range 

of Sample Types 

Forensics 

Trace Evidence, Solids, Residues, 

Powders, Liquids 

Industrial 

RoHS-WEEE, Quality Control, Failure Analysis, 

Coating Thickness/Composition 

Antiquities/Museum 

Artifact Authentication, Gemstones, Documents 

For more information on the Orbis Micro-XRF System 

visit our web site at www.EDAX.com/newxrf 

or call 1-800-535-EDAX.


Environmental Express 


Environmental Express 

490 Wando Park Boulevard 

Mount Pleasant, SC 29464 

TELEPHONE 

1 (800) 343-5319 

(843) 881-6560 

FAX 

(843) 881-3964 

E-MAIL 

info@environmentalexpress.com 

WEB SITE 

www.environmentalexpress.com 


50 

YEAR FOUNDED 

1988 


Environmental Express is a leading developer, manufacturer, 

and distributor of environmental laboratory equipment 

and consumable supplies for commercial, governmental, 

industrial, and academic laboratories worldwide. 

The company provides an entire range of laboratory products 

used in applications such as water/wastewater analysis, 

oil and grease analysis, metals analysis, and hazardous 

waste analysis. We pride ourselves on providing innovative 

products, superior technical support, knowledgeable customer 

service, and same day shipping. 


Various EPA Methodologies for GC, GC-MS and HPLC analytical 

techniques. 


⦁ Organics Laboratories 

⦁ Academic Laboratories 

⦁ Metals Laboratories 


⦁ Life Sciences 

⦁ Refining and Petrochemicals 


Environmental Express offers a full line 

of equipment and consumables to 

support EPA methodologies to include 

soil and liquid extraction equipment and 

analytical consumables. 

⦁ StepSaver for solid phase extraction 

⦁ Soil Extraction Cell, an alternative to 

the microwave for EPA Method 3546 

using a HotBlock and stainless steel 

Soil Extraction Cells 

⦁ SGE syringes, columns, inlet liners, 

and electron multipliers 

⦁ MicroLiter AutoSampler Vials 

⦁ Soxhlet Extraction Thimbles 

⦁ 3m Empore Disks 

⦁ Color-Coded Surrogates for BNAs 

⦁ Field Sampling Kits 

⦁ Organic Standards 

Facilities 

Our manufacturing and distribution facility 

occupies three buildings in Mount 

Pleasant, South Carolina. The campus 

also houses our sales and marketing, 

customer service, research and development, 

finance and executive teams.


Enwave Optronics, Inc. 

⦁ MicroSense Series for Raman microscopy 

applications 

⦁ Frequency-Stabilized Lasers 

⦁ Customized Raman Solutions 

⦁ OEM Products 

Facilities 

Enwave’s engineering, sales, manufacturing, 

and services office is located in 

Irvine, California. We also have partners 

and distributors in North America, Europe, 

Asia, Latin America, and Australia 

to meet the needs of our international 

customers. 


18200 W. McDurmott Street, 

Suite A 

Irvine, CA 92614 

TELEPHONE 

(949) 955-0258 

FAX 

(949) 955-0259 

E-MAIL 

info@enwaveopt.com 

WEB SITE 

www.enwaveopt.com 


US: 8 

Outside the US: 15 

YEAR FOUNDED 

2003 


Enwave Optronics, Inc. is an innovative leader in high performance 

and affordable Raman spectroscopy solutions. 

The Enwave engineering team has extensive knowledge 

in diode laser optical systems and Raman spectroscopy 

instrumentation. We specialize in providing solutions for 

Raman applications that other vendors are unable to solve. 

We provide full design, prototyping, R&D, manufacturing, 

and technical support. We are committed to assisting you 

resolve your most challenging application needs and to 

providing you with the best performance and quality solutions 

at the most affordable prices. 




Enwave’s instruments can be found and utilized for a wide 

range of applications and in a variety of industries such 

as: education, research, environmental, semiconductor, 

pharmaceutical, forensics, chemical, paper and pulp, food 

and beverage, biotechnology and life sciences, gemology/ 

mineralogy, and much more! 


⦁ EZRaman Series for laboratory and field Raman applications 

⦁ ProRaman Series for laboratory, on-line process monitoring, 

and other applications requiring high sensitivity


Parker Hannifin Corporation 

Filtration and Separation Division 


Parker Hannifin 

Corporation 

Filtration and Separation 

Division 

242 Neck Road 

Haverhill, MA 01835 

TELEPHONE 

(978) 858-0505 

FAX 

(978) 556-7501 

WEB SITE 

www.labgasgenerators.com 


55,000 

YEAR FOUNDED 

1924 


Safety: Parker Balston gas generators completely eliminate 

the safety hazards involved with handling high-pressure gas 

cylinders. Enjoy hassle-free automation with no tanks to 

change and no downtime. 

Reliability: Thousands of laboratories worldwide have Parker 

Balston gas generators in routine use. Parker Balston gas 

generators are recommended and used by major instrument 

manufacturers. We offer the best technology at an affordable 

price from the brand you trust. 

Quality: Each Parker Balston gas generator is manufactured 

under a strict total quality management program. We have a 

world-class ISO 9001–certified manufacturing facility in the 

United States. All Parker Balston gas generators are backed by 

a complete satisfaction guarantee. 

Products: Hydrogen gas generators produce 99.99999% pure 

hydrogen for gas chromatographs. Zero air generators produce 

zero grade air for gas chromatographs. UHP nitrogen generators 

produce 99.9999% pure nitrogen for GCs or ICP spectrometers. 

FTIR gas generators produce dry, CO 2 

-free purge gas 

for FTIR spectrometers. Pure air and nitrogen generators produce 

dry, ultrapure compressed gas for laboratory instruments, 

including LC–MS instruments. 


⦁ Optical 

⦁ Atomic 

⦁ Infrared 

⦁ Mass universal 

⦁ Hyphenated techniques 


⦁ Agriculture 

⦁ Biotechnology 

⦁ Chemicals 

⦁ Chemical and explosives detection 

⦁ Energy 


⦁ Inorganic chemicals 

⦁ Instrument development 

⦁ Life science 

⦁ Organic chemicals 

⦁ Paints and coatings 

⦁ Petrochemicals 


⦁ Plastics 


Gas generators for the following analytical 

instruments: 

⦁ Gas chromatographs 

⦁ LC–MS 

⦁ FTIR spectrometers 

⦁ ICP emission spectrometers 

⦁ TOC analyzers 

⦁ Atomic absorption spectrophotometers 

⦁ Nuclear magnetic resonance (NMR) 

⦁ Rheometers/thermal analyzers 

⦁ Sample evaporators/concentrators 

Facilities 

Parker Hannifin manufactures all gas 

generator products in Haverhill, Massachusetts. 

All Parker Balston products are manufactured 

in accordance with a strict Total 

Quality Management Program, ensuring 

top performance and long-term reliability. 

Distribution points stretch across the 

United States and worldwide, including 

Canada, the UK, China, India, Germany, 

France, Japan, and Singapore.


Harrick Scientific Products, Inc. 

Harrick Scientific 

Products, Inc. 

141 Tompkins Ave, 

2nd Floor 

Pleasantville, NY 10570 

TELEPHONE 

(800) 248-3847 

FAX 

(914) 747-7209 

E-MAIL 

info@harricksci.com 

WEB SITE 

www.harricksci.com 


21 

YEAR FOUNDED 

1969 


Harrick Scientific Products specializes in designing and 

manufacturing instruments for optical spectroscopy. Since 

being established in 1969, Harrick Scientific has advanced 

the frontiers of optical spectroscopy through its innovations 

in all spectroscopic techniques. The founder of the company, 

Dr. N.J. Harrick, pioneered ATR (attenuated total reflection) 

spectroscopy and became the principal developer of this 

technique. Harrick Scientific offers a complete selection of 

sampling accessories, including both standard and custom designs, 

as well as an extensive line of optical elements. 


⦁ Transmission 

⦁ Specular reflection 

⦁ Diffuse reflection 

⦁ ATR 

⦁ Fiberoptics 


Harrick Scientific serves analytical markets worldwide. Harrick’s 

customers typically are from research or quality control 

laboratories of industrial, governmental, research, and academic 

institutions throughout the world. Industries served 

include chemical, electronic, pharmaceutical, forensics, and 

biomedical. 


Harrick Scientific offers the most complete 

line of spectroscopy sampling products, 

including: 

⦁ Video Meridian — a diamond micro ATR 

accessory with built-in camera 

⦁ MVP Pro Star — an affordable 

monolithic diamond ATR accessory 

⦁ Praying Mantis — a diffuse reflectance 

accessory available with environmental 

chambers/reaction cells 

⦁ Seagull — a variable angle specular 

reflection and ATR accessory 

⦁ VariGATR — a variable angle grazing 

angle ATR accessory for monolayers on 

Gold and Silicon substrates 

⦁ FiberMate 2 — an interface between 

spectrometers and fiberoptic applications 

⦁ MultiLoop, Omni-Diff, and 

Omni-Spec — fiberoptic probes for ATR, 

diffuse reflection, and specular 

reflection 

⦁ A variety of liquid and gas transmission 

cells 

⦁ Custom design development 

Facilities 

Harrick Scientific Products is located 30 

miles north of New York City in Pleasantville, 

New York. Our products are also 

available through FT-IR and UV-Vis spectrometer 

manufacturers, as well as distributors 

in the United States and throughout 

the world.


Hellma USA, Inc. 


Hellma USA, Inc. 

80 Skyline Drive 

Plainview, NY 11803 

TELEPHONE 

(516) 939-0888 

WEB SITE 

www.hellmausa.com 

YEAR FOUNDED 

1922 


Hellma GmbH & Co., founded in 

1922, is the world market leader in 

cells, fiber optic probes, and optical 

components made of glass or quartz 

which are used for modern optical 

analysis. Hellma products are available 

worldwide through a network 

of Hellma sister companies and additional 

distribution agents. 


Custom Designed Products 

In addition to the large range of 

standard products, Hellma also 

manufactures special cells and other 

precision optical parts according 

to customer’s specifications. Hellma has more than 85 years 

experience in the field of glass machining and fabrication. Our 

specialists can carry out complex tasks and give full and competent 

advice regarding design ideas and any alternative possibilities. 

Analysis in space — processing at the cutting edge 

of technology 

A close collaboration with research institutes, universities, 

and scientific institutions is important for Hellma’s outstanding 

engineering competence. Based on this extensive 

know-how in processing techniques, Hellma is able to find 

unique solutions. Excellent examples of achievements are the 

individually designed, custom-made cells being used in the 

International Space Station (ISS) or those which were used in 

physics research that led to the winning of the Nobel Prize in 

1997 and 2001. 

The TrayCell — Fiber-optic ultra-micro cells for UV/Vis analysis 

Even in classical analysis the specialists at Hellma are always setting 

new standards. One of the most recent examples: the fiberoptic 

ultra-micro measuring cell “TrayCell,” which allows accurate 

analysis of DNA, RNA, or proteins in sample volumes of as low as 

0.7 μl. The dimensions of the TrayCell are equivalent to a standard 

cell in order to work in all common spectrophotometers. 

Features: 

⦁ Unique fiber optic ultra-micro measuring cell 

⦁ Works with 0.7–5 μl sample volume 

⦁ A single drop measuring sample is sufficient 

⦁ High precision and reproducibility 

⦁ Dilution is not necessary 

accredited DKD calibration laboratory 

of Hellma 

With the accreditation according to DIN 

EN ISO 17025, Hellma is one of the leading 

accredited calibration laboratories 

that produce and certify liquid and glass 

calibration filters made for testing spectrophotometers. 

Increased security and quality 

demands among laboratories require 

an improved traceability of measurement 

results to an internationally approved standard. 

An accreditation according to DIN EN 

ISO 17025 ensures the traceability of calibrations 

carried out to references of the 

NIST, by which an international correlation 

of measurement results is assured. Thus 

procedures in laboratories gain greater 

transparency and improved protection of 

their measurement results. 

Modern Flow Cytometry requires 

highest standards 

The heart of every flow cytometer is a 

small quartz glass flow channel providing 

reliable stability of the fluidic system and 

precise optical analysis of single cells. Due 

to sophisticated technologies Hellma is 

able to manufacture customer specified 

channel dimensions down to 50 μm × 

50 μm with any outside dimension and 

highly polished surfaces. 

Fiber–optical systems 

The development of fiber-optical systems 

has caused a small revolution in chemical 

analysis. This technology makes it possible 

to carry out photometric measurements 

not only under laboratory conditions with 

cells, but also outside the lab. Through 

the development of fiber-optic probes, 

analysis has moved directly to the process 

for measurements with continuous measurements 

possible without sampling. This 

allows for better control of ongoing processes 

with much less effort. 

Complete traceability and excellent reliability of measurement 

results — with UV/Vis calibration standards from the


HORIBA Scientific 

⦁ Metals, plastics, polymers, etc. 

⦁ Optoelectronics 

⦁ Petroleum 


⦁ Semiconductors 

HORIBA Scientific 

3880 Park Avenue 

Edison, NJ 08820 

TELEPHONE 

(732) 494-8660 

FAX 

(732) 494-5125 

E-MAIL 

info.sci@horiba.com 

WEB SITE 

www.horiba.com/scientific 


USA: 600 


YEAR FOUNDED 

1819 


HORIBA Scientific is a leading manufacturer of innovative 

spectroscopic systems and components, and we are committed 

to serving our customers with superior products and 

technical support in optical spectroscopy. 

HORIBA Scientific is part of the HORIBA Group, which employs 

5,000 people worldwide, with annual sales in excess of 

$1.5 billion. HORIBA Jobin Yvon, Sofie, Dilor, Spex®, and IBH 

are some of our well-known and respected brand names. 


⦁ Molecular fluorescence spectroscopy 

⦁ Optical spectroscopy 


⦁ Ellipsometry and thin-film analysis 

⦁ Atomic emission spectroscopy 

⦁ Fluorescence 

⦁ Forensic science 


⦁ Academia 

⦁ Coatings 


⦁ Forensic science 

⦁ Life sciences 

⦁ Medical 


⦁ Spectroscopy and analysis 

⦁ Elemental analyzers 

⦁ Ellipsometers 

⦁ End-point detectors 


⦁ Gratings 

⦁ ICP & GD spectrometers 

⦁ Lifetime fluorescence 

⦁ Microscopy 

⦁ OEM components 

⦁ Particle-size analyzers 

⦁ Process control 

⦁ Raman & FT-IR 

⦁ Spectrographs 

⦁ Spectrometers and CCDs 

⦁ VUV equipment 

⦁ X-Ray fluorescence 

⦁ Surface Plasmon Resonance Imaging 

(SPRi) 

⦁ Particle-size systems 

Facilities 

HORIBA Scientific manufactures quality 

instruments in Edison, New Jersey, as well 

as France and Japan. 

Sales, service, and applications facilities 

are located around the world. We are an 

ISO 9001:2008-certified company.



International Centre for Diffraction Data 

is a powerful tool for phase identification 

using physical, chemical, and crystallographic 

data. It contains numerous 

features such as 301,282 data sets, digitized 

patterns, molecular graphics, and 

atomic parameters. Many new features 

have been incorporated into PDF-4+ to 

enhance the ability to do quantitative 

analysis by any of three methods: Rietveld 

analysis, reference intensity ratio 

(RIR) method, or total pattern analysis. 

PDF-4+ also features electron diffraction 

simulations based on atomic structure 

and electron diffraction scattering factors 

on >270,000 data sets. 

International Centre for 

Diffraction Data 

12 Campus Boulevard 

Newtown Square, PA 19073 

TELEPHONE 

(610) 325-9814 

FAX 

(610) 325-9823 

E-MAIL 

info@icdd.com 

WEB SITE 

www.icdd.com 


40 

YEAR FOUNDED 

1941 


ICDD, a not-for-profit corporation, is dedicated to the collecting, 

editing, and publishing of the Powder Diffraction 

File (PDF ® ). Our mission is to continue to be the world 

center for quality diffraction and related data to meet the 

needs of the technical community. ICDD promotes the 

application of materials characterization methods in science 

and technology by providing forums for the exchange 

of ideas and information, which includes sponsoring the 

Denver X-ray Conference; Advances in X-ray Analysis; 

and Powder Diffraction. ICDD and its members conduct 

workshops and clinics on materials characterization at our 

headquarters in Pennsylvania and at global X-ray analysis 

conferences. 


⦁ X-ray diffraction 

⦁ Electron diffraction 

⦁ Electron backscatter diffraction 


The Powder Diffraction File is designed for materials identification 

and characterization. ICDD databases are used 

worldwide by scientists in academia, government, and industry 

who are actively engaged in the field of X-ray powder 

diffraction and related disciplines. 


PDF-4+ 2010 is our advanced database with comprehensive 

material coverage for inorganic materials. The database


Inorganic Ventures 

development, textile, transportation, and 

wastewater treatment, to name a few. 

Inorganic Ventures 

300 Technology Drive 

Christiansburg, VA 24073 

TELEPHONE 

(800) 669-6799 (US & 

Canada) 

(540) 585-3030 

FAX 

(540) 585-3012 

E-MAIL 

info@inorganicventures.com 

WEB SITE 

inorganicventures.com 

YEAR FOUNDED 

1985 


Inorganic Ventures is the only standard manufacturer to specialize 

in the formulation of custom inorganic solutions. We 

excel in providing service and support tailored to your specific 

needs. In short, we flex to your specs. 

Our specialization in custom blending means that we can 

create precise standards faster than other manufacturers. Over 

99% of our custom blends ship within five business days or 

less. In addition to customization, we offer a wide selection 

of stock inorganic standards. Contact us to receive our new 

catalog. 

For nearly a decade, Inorganic Ventures has been registered 

to ISO Guide 34, ISO/IEC 17025, and ISO 9001 by A2LA 

and QMI. 


⦁ ICP-OES/AES 

⦁ ICP-MS 

⦁ IC 

⦁ AA 

⦁ GFAA 

⦁ DCP 


We provide custom and conventional certified reference 

materials for dozens of markets, including aeronautical, agricultural, 

automotive, chemical, colleges and universities, construction, 

cosmetic, energy, environmental, food industries, 

government agencies, medical, metallurgical, military, mining, 

nuclear, petroleum, pharmaceutical, plastics, research and 


Our specialists customize and manufacture 

inorganic standards for laboratories 

worldwide. We create aqueous calibration 

standards, quality control standards, and 

chemical reagents, plus a wide selection 

of ion chromatography standards and 

CRMs for the latest EPA methods. Over 

99% of our custom solutions ship within 

five business days. Stock orders ship 

same-day prior to 4:00 pm EST. Experts 

are available during regular business hours 

to provide in-depth technical support. Furthermore, 

the Inorganic Ventures’ website, 

inorganicventures.com, has been cited by 

chemists as one of the best sources for 

analytical support on the Web. 

Facilities 

In 2009 we completed our corporate relocation 

to our new state-of-the-art manufacturing 

laboratory in Christiansburg, 

Virginia. This eco-friendly laboratory offers 

contamination-free manufacturing during 

every stage of production. Most foreign 

orders ship from our European distribution 

center in Madrid, Spain.


Innovative Photonic Solutions 


Innovative Photonic 

Solutions 

4250 U.S. Highway 1, Suite 1 

Monmouth Junction, NJ 

08852 

TELEPHONE 

(732) 355-9300 

FAX 

(732) 355-9302 

E-MAIL 

srudder@ 

innovativephotonics.com 

WEB SITE 

www. 

innovativephotonics.com 

YEAR FOUNDED 

2003 


Innovative Photonic Solutions (IPS) was founded in 2003 to 

address the market need for high performance semiconductor 

light sources that enable the customer to precisely specify the 

emission wavelength, output power, and spectral linewidth for 

their particular application. Focusing on markets such as Raman 

spectroscopy, laser pumping & seeding, and frequency doubling 

applications; IPS supplies high performance OEM solutions and 

“turn-key” systems for the most demanding projects. Our corporate 

philosophy is to take on our customer’s most challenging 

problems and provide them with Innovative Photonic Solutions. 



⦁ FTIR & NIR spectroscopy 


IPS’ unique wavelength stabilization technology is leading the 

way in the development of low-cost, low power consumption 

semiconductor laser engines for emerging technology applications 

such as Raman, FTIR and NIR spectroscopy, medical diagnostics, 

and scientific instrumentation. Customers can request 

exact laser parameters, such as output power level, emission 

wavelength and spectral linewidth, and obtain overwhelmingly 

consistent product performance even in high volume manufacturing 

quantities. This technology can be applied to both 

single and multi-spatial mode lasers, can be delivered as either 

open beam or fiber coupled, and is available in a wide variety of 

packaging solutions — ranging from our ultra small TO-56 package 

(13 mm long × 5.6 mm dia) to our fully turn-key laboratory 

bench systems. Sources can be manufactured at wavelengths 

ranging from 405–1700 nm, and are ideal for Raman spectroscopy 

applications due to their ultra-high performance wavelength 

and power stability characteristics. 


-Raman Spectroscopy Sources 

IPS offers a complete product portfolio of 

lasers for Raman spectroscopy. Standard 

products include both single and multi-mode 

lasers with fiber coupled or open beam output 

and power as high as 6 W. These units 

are available as OEM components or in fully 

turn-key modules with integral drive and 

temperature control electronics. 

Our newest product releases include a 

TO-56 packaged wavelength stabilized laser 

with integral laser line filter that is specifically 

designed for integration into portable Raman 

systems; single & multi-mode wavelength 

stabilized lasers with “ultra-track” and “microisolator” 

technologies to provide absolute 

power knowledge and retro-reflection insensitivity; 

an OEM Raman module designed 

for use with confocal Raman microscopy 

systems; and a single frequency 532 nm 

source that is ideal for both confocal Raman, 

portable Raman, and SERDS. 

-Custom Optical Probe Heads 

IPS’ line of Probe Heads have been designed 

for portability and applications where both 

size and weight matters. Designed to interface 

with virtually any spectrometer, these innovative 

designs lower overall system costs by 

reducing component count and minimizing 

optical losses. This leads to small, efficient, 

and compact Raman system solutions. 

Facilities 

Located in the Princeton, New Jersey area at 

the heart of the photonics corridor and centrally 

located between New York and Philadelphia, 

IPS’ 8,000 square foot facility houses 

a complete prototyping and high rate production 

assembly line. Key equipment includes 

packaging and precision alignment systems, 

high resolution inspection microscopy, and 

both optical and electrical test apparatus.

z Ultra-High Stability ('O < 0.007 nm/ 0 C) 

z Narrow Spectral Linewidth 

- Single Mode < 1 MHz 

- Multi-Mode < 1 cm -1 

z < 1 % Power Stability 

z OEM or Turn-key Systems 

z Instant On 

- Stable to < 1 cm -1 in < 1 sec. 

z Linear Tracking Photodiode 

z Fiber Coupled or Open Beam 

z Low Power Consumption 

z Integral Laser Line Filter 

and of course... 

z Immunity to Optical Feedback 

Wavelength Stabilized 

Raman Excitation Sources 

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IPS supplies wavelength stabilized laser sources to over 

70% of all Raman system manufacturers world wide! 

Why risk going anywhere else? 

New Raman Laser Sources 

Single Frequency 532 nm OEM Module 

OEM Style A-Type Module 

This novel direct diode frequency doubled (DDFD) source 

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power with single spatial mode operation and a single 

frequency wavelength. The source is rapidly tunable 

over several nanometers - making it an ideal source 

for Shifted Excitation Raman Difference Spectroscopy 

(SERDS). The unit is available in both OEM U-Type 

packaging and turn-key M-Type laboratory systems. 

Designed as a drop-in replacement for micro laser 

system sources, the IPS A-Type module offers superior 

performance due to our unique wavelength stabilization 

technique. IPS A-type modules provide > 100 mW 

of output power with a circularized and collimated 

Gaussian output beam. The modules have an integral 

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For more information visit us on the web at www.innovativephotonics.com or call (732) 355-9300


Iridian Spectral Technologies 



Iridian is the leader in optical filter solutions for UV, visible, and near-IR applications. Our dielectric 

thin-film filters provide long term durability and reliability with industry leading optical performance. 

Get more signal with less background with our optical filters for Raman spectroscopy. We provide 

pass band transmittances of >90%, exceptional edge steepness, and blocking of >OD6. 

Capture better images with our single or multi-band filters for fluorescence spectroscopy and 

microscopy and flow cytometry. Our filters have high transmission with sharp cutoffs and excellent 

isolation providing brighter imaging and improved image contrast. 



⦁ Confocal fluorescence microscopy 

⦁ Flow cytometry 


Iridian’s optical filter offerings address the needs of spectroscopists and spectroscopy instrument 

OEMs around the world. We provide direct sales support as well as offering sales via distributors in 

the UK, Japan, China, and Korea. 

Iridian Spectral 

Technologies 

1200 Montreal Road 

M-50, Ottawa 

ON K1A 0R6 

Canada 

Facilities 

Iridian’s operations are located in Ottawa, Ontario, Canada. 

TELEPHONE 

(613) 741-4513 

FAX 

(613) 741-9986 

E-MAIL 

sales@iridian.ca 

WEB SITE 

www.iridian.ca 


120 

YEAR FOUNDED 

1998


Newport Corporation 

of knowledge across a broad spectrum of 

products, along with the ability to deliver unsurpassed 

solutions and integration. 

Newport Corporation 

1791 Deere Avenue 

Irvine, CA 92606 

TELEPHONE 

(800) 222-6440 

FAX 

(949) 253-1800 

E-MAIL 

sales@newport.com 

WEB SITE 

www.newport.com 

YEAR FOUNDED 

1969 


Newport is a world leading supplier of innovative photonic solutions 

to Make, Manage, and Measure Light SM . The company’s 

broad product portfolio includes an extensive selection of lasers, 

high-quality light sources, optomechanics, optics, filters, gratings, 

crystals, optical tables, and motion systems. As the industry’s first 

and only integrated supplier of laser and photonic components, 

Newport does more than just deliver components. We also leverage 

a unique ability to integrate multiple core technologies, a 

full range of engineering design services, metrology certification, 

manufacturing control programs, and world-class service and 

support, and offer a wide variety of subsystems, subassembly, 

and turnkey systems to our customers. 


⦁ UV–Vis 

⦁ Infrared 


⦁ Raman 

⦁ Ultrafast 


Newport provides advanced-technology products to the 

research, aerospace and defense, life and health sciences, photovoltaics, 

semiconductor, and microelectronics markets. 

For over 40 years Newport has continued to grow and 

today is built upon world-class brands such as Corion ® , 

New Focus, Oriel ® Instruments, Richardson Gratings, and 

Spectra-Physics ® . Alone, each of these brands has a rich history of 

product innovation and expertise. Together they deliver a synergy 


As a combined force, Newport, and its family 

of brands, is a premier global resource for 

solutions to Make, Manage, and Measure 

light. Newport’s breadth of product offerings, 

combined with our experience and 

expertise, allows us to meet our customers 

at any place on the technology roadmap. 

Our lasers, photonic instrumentation, optical 

tables, motion control solutions, optics, filters, 

gratings, opto-mechanics, and spectroscopy 

instruments are used in research and 

scientific laboratories, microelectronics and 

semiconductor manufacturing, life & health 

sciences, aerospace & defense, and industrial 

manufacturing. Expanding upon a 40+ year 

history of innovation in photonics, Newport 

is a single-source provider for all your laser 

and photonics needs. 

Facilities 

Newport Corporation has offices in over 

10 countries worldwide, including over 

600,000 square feet of office and manufacturing 

space. The company is headquartered 

in Irvine, California. This facility 

houses sales, marketing, engineering, 

and manufacturing, including facilities for 

optics, opto-mechanical assemblies, and 

instrumentation. The Spectra-Physics and 

New Focus laser manufacturing facilities 

are headquartered in Santa Clara, California. 

Other offices include Oriel spectroscopy 

products in Stratford, Connecticut; 

Richardson Gratings in Rochester, New 

York; Corion filter products and replicated 

mirrors in Franklin, Massachusetts; manufacturing 

facilities in Darmstadt, Germany, 

and Evry, France; and numerous local 

sales offices throughout Europe and Asia.


Moxtek, Inc. 


⦁ MAGNUM Miniature X-ray Sources — 

The leading X-ray source technology for 

handheld and bench top X-ray analysis 

applications. 

⦁ XPIN Detectors — The latest generation 

of affordable Si-PIN detectors for X-ray 

fluorescence spectrometry. 

⦁ AP3 and ProLINE Windows — Ultrathin 

polymer windows for energy and 

wavelength dispersive spectroscopy. 

⦁ DuraBeryllium Windows — The most 

rugged and reliable beryllium windows 

available for X-ray applications. 

⦁ MX Series JFET — The lowest noise JFET 

available for X-ray detection systems. 

Moxtek, Inc. 

452 W 1260 N 

Orem, UT 84057 

TELEPHONE 

(801) 225-0930 

FAX 

(801) 221-1121 

E-MAIL 

moxtek@moxtek.com 

WEB SITE 

www.moxtek.com 


142 

YEAR FOUNDED 

1986 


We are a leading supplier of X-ray and optical components for 

analytical instrumentation and display electronics. Products 

include the new XPIN high-performance Si-PIN X-ray 

detectors; MAGNUM ® miniature low-power X-ray sources; AP3 

and DuraBeryllium ® X-ray windows for EDS; ProLINE windows 

for WDS; and ProFlux ® wire-grid polarizers and beam splitters 

for UV, visible, and IR spectroscopy. Moxtek is well known for 

advanced technology, innovative solutions, and excellent 

customer service. 


⦁ Energy dispersive X-ray spectroscopy 

⦁ Wavelength dispersive X-ray spectroscopy 

⦁ X-ray diffraction 

⦁ Microanalysis 

⦁ UV, visible, IR spectrometry 


Moxtek, Inc. serves the analytical instrumentation and 

projection display markets. 


⦁ ProFlux Wiregrid Polarizers — High transmission and 

contrast inorganic polarizers for UV, visible, and IR 

applications.

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Nippon Instruments North America 


budget requirements. These analyzers 

provide simple, highly effective results 

for such methods as EPA 245.1. 

⦁ Model RA-3420 Mercury Analyzer: A 

unique analyzer that performs the typical 

EPA Method 245.1 analysis in a fully 

automatic sequence, including sample 

preparation. 

⦁ Model PE-1000 Mercury Analyzer: A 

specifically designed mercury analyzer 

for direct, automated analysis of mercury 

in liquid and gaseous hydrocarbons. 

Nippon Instruments 

North America 

1511 Texas Ave S #270 

College Station, TX 77840 

TELEPHONE 

(979) 774-3800 

FAX 

(979) 774-3807 

E-MAIL 

sales@hg-nic.us 

WEB SITE 

www.hg-nic.us 


19 

YEAR FOUNDED 

2003 


Nippon Instruments North America is the regional office for 

Nippon Instruments Corporation-Japan. Nippon Instruments 

has over 30 years of experience in the design and manufacture 

of high-quality mercury analyzers. With an absolute focus 

on mercury analyzers, Nippon Instruments offers mercury analyzers 

for just about every application. From systems for most 

EPA methods to direct mercury analyzers to online monitoring 

systems to specially designed systems for the petrochem 

industry, Nippon Instruments has a mercury analyzer for your 

laboratory. 


⦁ Atomic absorption spectroscopy 

⦁ Atomic fluorescence spectroscopy 


Nippon Instruments provides mercury analyzers for EPA compliance 

monitoring in the environmental, government, and 

industrial markets. We provide highly versatile systems for the 

research and education markets, as well as mercury analyzers 

that are specifically designed for the unique tasks of the 

industrial and petrochem markets. 


⦁ Model MA-2000 Mercury Analyzer: A direct mercury 

analyzer that allows for mercury analysis of just about any 

matrix without the need for sample preparation. 

⦁ Model RA-3000 Series Mercury Analyzers: Mercury analyzers 

with several configurations available to fit various 

Facilities 

Nippon Instruments North America is in 

the final stages of building a new office in 

College Station, Texas, in order to continue 

to expand our capabilities. Nippon Instruments 

Corporation currently maintains offices 

in Osaka and Tokyo, Japan, as well as 

an additional office in Singapore.


OI Analytical 


OI Analytical provides instruments for 

spectroscopic analysis including: 

⦁ iTOC-CRDS Isotopic Carbon Analyzer 

⦁ IonCam Mass Spectrometer 

⦁ IonCam 2020 Transportable GC–MS 

⦁ IonCCD Array Detector 

⦁ DA 3500 Discrete Analyzer 

⦁ FS 3100 Automated Chemistry Analyzer 

Facilities 

OI Analytical operates research and manufacturing 

sites in College Station, Texas 

and Birmingham, Alabama occupying 

88,000 square feet. 

OI Analytical 

151 Graham Road 

P.O. Box 9010 

College Station, TX 77842 

TELEPHONE 

(979) 690-1711 

(800) 653-1711 

FAX 

(979) 690-0440 

E-MAIL 

oimail@oico.com 

WEB SITE 

www.oico.com 


135 

YEAR FOUNDED 

1969 


OI Analytical designs, manufactures, markets, and supports 

analytical instruments used for sample preparation, detection, 

and measurement of chemical compounds and elements. ITT 

Analytics acquired OI Analytical on November 16, 2010. OI 

Analytical is based in College Station, Texas, with a second 

facility in Birmingham, Alabama. 


⦁ Total organic carbon-cavity ring down spectroscopy (TOC- 

CRDS) 

⦁ Mass spectrometry 

⦁ Gas chromatography–mass spectrometry (GC–MS) 

⦁ Discrete analysis 

⦁ Flow injection analysis (FIA) 

⦁ Segmented flow analysis (SFA) 


Principal markets/industries served include environmental 

testing, drinking and wastewater treatment, chemicals and 

petrochemicals, pharmaceuticals, food and beverage, homeland 

security, and chemical weapons demilitarization. 

Opportunity 

OI Analytical 

Innovation TM


Ocean Optics, Inc. 


Ocean Optics 

830 Douglas Ave. 

Dunedin, FL 34698 

TELEPHONE 

( 727) 733-2447 

FAX 

( 727) 733-3962 

E-MAIL 

info@oceanoptics.com 

WEB SITE 

www.oceanoptics.com 


250 

YEAR FOUNDED 

1989 


Ocean Optics invented the world’s first miniature spectrometer 

and has delivered over 130,000 of them since its inception 

in 1989. The company provides solutions for diverse applications 

of optical sensing in medical and biological research, 

environmental regulation, science education, production, and 

process control. Ocean Optics also provides a comprehensive 

range of complementary technologies including chemical sensors, 

metrology instrumentation, optical fibers, probes, filters, 

coatings, and many more spectroscopic peripherals and accessories. 

Our spectrometers and sensors are also ideal for 

OEM applications — with modular options that meet virtually 

any application requirement. 


Absorbance, transmission, reflectance, irradiance, fluorescence, 

Raman, UV/VIS/NIR, spectroradiometry, color spectroscopy, 

laser-induced breakdown spectroscopy (LIBS), fiber 

optic chemical sensing, flow injection analysis, elemental 

analysis, endpoint detection, headspace monitoring, laser 

characterization, nondestructive testing, multi-spectral 

imaging. 


Ocean Optics technologies can be found in a diverse range of 

industries and disciplines. Our products are used by innovators, 

researchers, scientists, OEMs, medical and healthcare 

professionals, and in manufacturing facilities in every country 

on the planet. Military and security concerns have incorporated 

Ocean Optics technologies into their equipment while 

the research community has embraced 

our systems and components for everything 

from cancer detection to solar cell 

analysis. In fact, you can find Ocean Optics 

products in virtually any application from 

food safety to forensics and from semiconductors 

to marine biology. 


⦁ Spectrometers: UV/VIS/NIR, highresolution, 

time-gated fluorescence, 

spectrofluorometers, absorbance, laserinduced 

breakdown, LED measurement, 

reflectance, Raman, remote sensing, 

field measurement. 

⦁ Optical Sensors: Oxygen sensors, pH 

sensors, transducing materials. 

⦁ Software: Spectrometer operating, 

device drivers, irradiance, reflective and 

emissive color, compound identification. 

⦁ Sampling Accessories: Collimating 

lenses, cuvettes and holders, standards, 

filters and holders, flow cells, cosine 

correctors, integrating spheres. 

⦁ Light Sources: Deuterium, tungsten 

halogen, LED, excitation sources, lasers. 

⦁ Optical Fibers and Probes: Premium 

grade assemblies, bare fiber, custom 

options, reflection and transmission 

probes, vacuum feedthroughs, 

complete fiber kits. 

Facilities 

Ocean Optics is headquartered in Dunedin, 

Florida and has full-service locations in Europe 

as well as China. Ocean Optics is part 

of Halma p.l.c., a safety and environmental 

technology group in the United Kingdom.


OptiGrate Corp. 


OptiGrate Corp. 

3267 Progress Drive 

Orlando, FL 32826 

TELEPHONE 

(407) 381-4115 

FAX 

(407) 384-5995 

E-MAIL 

info@optigrate.com 

WEB SITE 

www.optigrate.com 


25 

YEAR FOUNDED 

1999 


OptiGrate Corp. designs and manufactures ultra narrow band 

optical filters based on volume Bragg grating (VBG) technologies 

in proprietary photosensitive glass. Filters with bandwidth 

as low as 30 pm are formed by holographic techniques in the 

bulk of glass material and demonstrate superior optical quality, 

outstanding durability, and high optical damage threshold. 

OptiGrate is a pioneer and world leader in VBG technologies 

and, for over 10 years, OptiGrate has delivered custom build 

and volume orders of holographic optical elements (HOE) to 

a large number of government contractors and OEMs. 

OptiGrate has an exclusive license to a full portfolio of unique 

VBG-based products deployed in various industries. 


OptiGrate supplied ultra narrow band filters to hundreds of 

customers on five continents. The filters are used in a wide 

range of applications for optoelectronic, analytical, defense, 

and semiconductor industries. Major markets include: 


⦁ Semiconductor, solid state, and fiber lasers 

⦁ Hyperspectral and Raman imaging 

⦁ Photonics applications in the defense sector 

⦁ Ultrafast laser systems 

⦁ Optical recording and storage 

⦁ Medical diagnostics and treatment 


⦁ Optical Notch Filters — laser line rejection filters with bandwidth 

< 10 cm -1 . 

⦁ Optical Bandpass Filters — laser sidemode 

suppression filters with bandwidth 


Optometrics Corporation 



⦁ Scientific & analytical instrumentation 

⦁ FT-IR accessories 

⦁ Environmental & process monitoring 

⦁ Homeland security 

⦁ Scientific research 

⦁ Military 

⦁ Laser manufacturers 

Optometrics Corporation 

8 Nemco Way 

Ayer, MA 01432 

TELEPHONE 

(978) 772-1700 

FAX 

(978) 772-0017 

E-MAIL 

sales@optometrics.com 

WEB SITE 

www.optometrics.com 


45 

YEAR FOUNDED 

1969 


Optometrics has a distinguished 40 year history of manufacturing 

and providing optical components, in particular diffraction 

gratings and interference filters, for a wide range of 

spectroscopic and laser applications. Optometrics’ goal is to 

provide advanced optical components and systems for use in 

wavelength selection applications. Products include diffraction 

gratings, interference filters, components for military and civilian 

sighting and ranging equipment, monochromators, and 

ruled and holographic wire grid polarizers and beamsplitters. 

Optometrics caters, in particular, to the needs of its OEM 

customers by offering special services such as kanban stocking, 

bar coding capabilities, custom packaging programs, and 

higher level pre-aligned optical assemblies. 


⦁ UV, Visible, IR spectrometry 

⦁ Infrared (including FT-IR) 



⦁ Laser 

⦁ Liquid chromatography – mass spectrometry 

⦁ High performance liquid chromatography 

⦁ Color spectroscopy 


⦁ Diffraction gratings, ruled & holographic, 

originals or replicated, reflection and 

transmission 

⦁ Interference filters from 334–1650 nm 

⦁ Ruled & holographic wire grid 

polarizers 

⦁ Laser gratings 

⦁ Monochromators 

⦁ Tunable light sources 

⦁ Light sources, sample compartments, 

stepper motor controllers 

⦁ Components for military and civilian 

sighting and ranging equipment 

⦁ Beamsplitters 

Facilities 

Optometrics’ facility in Ayer, Massachusetts 

contains space for offices, engineering, 

R&D, and production. Equipment that supports 

our broad range of capabilities include 

four metal vacuum coating systems, 

three filter vacuum systems, two ionassisted 

hard coat vacuum systems, three 

grating ruling engines, two holographic 

laboratories, full replication and lamination 

facilities as well as full assembly, 

alignment, and test facilities. Optometrics 

is a wholly-owned subsidiary of Dynasil 

Corporation.


PerkinElmer, Inc. 



PerkinElmer is a global scientific leader providing an extensive 

range of technology solutions and services to address the 

most critical issues facing humanity. From critical research and 

prenatal screening to environmental testing and industrial 

monitoring, we’re actively engaged in improving health and 

enhancing quality of life all around the world. 


PerkinElmer, Inc. offers a wide breadth 

of instrumentation and solutions to meet 

your analytical measurement needs: 

⦁ Atomic spectroscopy: AA, ICP-OES, 

ICP-MS 

⦁ Chromatography: GC & GC Custom Solutions, 

GC–MS, HPLC & UHPLC 

⦁ Hyphenated techniques: HPLC-ICP- 

MS,GC-ICP-MS, HS-GC, HS-GC–MS, 

TD-GC, TD-GC–MS, TG-IR, TG-MS, TG- 

GC–MS, DSC-Raman 

⦁ Mass spectrometry: ICP-MS, GC–MS, 

LC–MS 

⦁ Molecular spectroscopy: FT-IR & FT-NIR, 

UV-Vis & UV-Vis-NIR, Raman spectroscopy, 

fluorescence spectroscopy 

⦁ Thermal analysis: DSC, TGA, STA, DMA 

⦁ Organic elemental analysis: CHN/O, 

CHNS/O 

⦁ Consumables: Atomic spectroscopy, 

chromatography, molecular spectroscopy, 

thermal analysis, elemental 

analysis 

⦁ OneSource ® Laboratory Services 

PerkinElmer, Inc. 

940 Winter Street 

Waltham, MA 02451 

TELEPHONE 

(203) 925-4602 

FAX 

(203) 944-4904 

E-MAIL 

as.info@perkinelmer.com 

WEB SITE 

www.perkinelmer.com 


2,300 (in the US) 

6,500 (outside the US) 

YEAR FOUNDED 

1937 


⦁ Atomic absorption 

⦁ Inductively coupled plasma (ICP-OES and ICP-AES) 

⦁ ICP mass spectrometry (ICP-MS) 

⦁ Infrared (FT-IR & FT-NIR) spectroscopy 

⦁ UV-Vis & UV-Vis-NIR 



PerkinElmer is a leading provider of precision instrumentation, 

reagents and chemistries, software, and services for a 

wide range of scientific and industrial laboratory applications, 

including environmental monitoring, food and beverage quality/safety, 

and chemical analysis, as well as genetic screening, 

drug discovery, and development. 

Facilities 

PerkinElmer, Inc. operates globally in 150 

countries.

©2010 PerkinElmer, Inc. 400190A_04. All rights reserved. PerkinElmer ® is a registered trademark of PerkinElmer, Inc. All other trademarks are the property of their respective owners. 

DO THINGS 

THE WAY 

YOU WANT. 

NEXION 300 ICP-MS 

Don’t let your ICP-MS put limits on the way you work. Engineered to 

deliver a level of stability, flexibility and performance never before seen in atomic 

spectroscopy, the NexION ® 300 represents the first truly significant industry 

advancement in recent memory. For the first time ever, a single instrument offers 

three modes of operation (Standard, Collision and Reaction), allowing analysts 

to choose the most appropriate technique for a specific sample or application. All 

while delivering superior accuracy, beter detection limits, and faster analysis times. 

NexION 300. Designed to stand out from the crowd – www.perkinelmer.com/nexion 

See the NexION at one of our seminars – www.perkinelmer.com/ASLSeventsNA


Pair Technologies, LLC 



Pair Technologies was founded to capitalize on the unique 

capabilities of planar array infrared spectroscopy. We offer a 

group of products that provide extremely rapid spectra, unmatched 

long term stability, and no moving parts. Products 

are easily customized for specific applications. 


⦁ Planar array mid-infrared spectroscopy 


⦁ Research 

⦁ Education 

⦁ Government 


⦁ Pair 100 series spectrometer systems 

Facilities 

Offices at Delaware Technology Center in Newark, Delaware. 

Pair Technologies, LLC 

1 Innovation Way 

Newark, DE 19711 

TELEPHONE 

(302) 368-7247 

E-MAIL 

info@pairtech.com 

WEB SITE 

www.pairtech.com 


5 

YEAR FOUNDED 

2008


Photon etc. 


⦁ Space and astronomy 

⦁ Environment and agriculture 

⦁ Mining, oil, and gas operations 

⦁ Art authentification, restoration, and 

conservation 


Photon etc’s standard products include: 

⦁ Widefield hyperspectral imaging systems 

⦁ Microscopy hyperspectral imaging system 

⦁ Tunable laser sources 

⦁ Supercontinuum lasers 

⦁ Tunable bandpass filters 

⦁ Tunable notch filters 

⦁ Resonance Raman spectroscopy systems 

⦁ Custom projects and internal R&D programs 

Photon etc. 

5795 av. de Gaspé #222 

Montreal, QC, H2S 2X3 

Canada 

TELEPHONE 

(514) 385-9555 

FAX 

(514) 279-5493 

E-MAIL 

info@photonetc.com 

WEB SITE 

www.photonetc.com 


20 

YEAR FOUNDED 

2002 


As pioneers in Bragg-based hyperspectral imaging, Photon etc. 

specializes in state-of-the-art photonic and optical research instrumentation. 

Driven by scientific expertise and its spirit of innovation, 

Photon etc. aims to remain a leader in this field. 

Photon etc’s patented spectral imaging, optical filter, and sensor 

technologies provide solutions for a wide variety of scientific 

and industrial applications. From material analysis to medical 

imaging, Photon etc’s products permit its clients to explore new 

territories of measurement and analysis. 


⦁ Nanomaterial and green material analysis 

- High resolution PL imager for PV and LED analysis 

- RRS system for carbon nanotubes and nanostructure 

research 

- Widely tunable lasers source for single molecule PL 

⦁ Industrial material analysis: 

- Hyperspectral imaging of geological formation 

- Multi-band LIBS for sulfur and carbon monitoring 

⦁ Molecular spectroscopy in life science: 

- PL and Raman imaging of biosensors 

- Hyperspectral imaging of the retina for AMD diagnostic 

- Hyperspectral imaging of the whole body for dermatology 

clinical studies 

- Tunable filter and broadband source for CARS 


⦁ Scientific research 

⦁ Pharmaceuticals and petrochemicals 

Facilities 

Photon etc. is both a research and development 

company and a specialized 

manufacturer of measurement and analysis 

instruments. Photon etc’s headquarters are 

located in Montreal, Canada. 

Its distribution network includes partners in: 

⦁ France (Opton Laser International and 

Leukos) 

⦁ Japan (Tokyo Instruments) 

⦁ Germany (Soliton GmbH) 

⦁ United Kingdom (Pacer International) 

⦁ Israel (Toyoram Electronics) 

⦁ China (Hoaliang Tech Co.) 

⦁ Korea (Hanbek Co.)


PHOTONIS USA 


PHOTONIS USA 

Sturbridge Business Park 

660 Main Street 

Sturbridge, MA 01566 

TELEPHONE 

(508) 347-4000 

(800) 648-1800 

FAX 

(508) 347-3849 

E-MAIL 

sales@usa.photonis.com 

WEB SITE 

www.photonis.com 


USA: 150 


YEAR FOUNDED 

1937 


PHOTONIS is a leading developer, 

manufacturer, and 

supplier of scientific detector 

products and components 

for scientific and 

analytical instrumentation 

systems. We specialize in 

ion, electron, and photon 

detection with unrivaled 

expertise in designing and 

delivering standard and 

custom products to meet 

the most demanding applications. 

Our engineering and 

manufacturing expertise 

delivers solutions for virtually 

every detection application. 

With the PHOTONIS 

worldwide manufacturing 

capability and support network, we can both design and 

manufacture your most challenging detection needs. 


⦁ Mass spectrometry 

⦁ Time of flight MS 


⦁ Nuclear spectroscopy 

⦁ UV and X-ray spectroscopy 

⦁ Charged particle imaging 

⦁ Electron microscopy 

⦁ Residual gas analysis/leak detection 

⦁ E-beam/X-ray lithography 

⦁ Luminescence 


⦁ Atomic absorption 

⦁ Deep UV/X-ray optics 


PHOTONIS detection products are found in most of today’s 

high technology-based markets, including scientific and 

analytical instrumentation, medical diagnostics, chemistry, 

scientific research, life sciences, space and geophysical 

exploration, environmental and process monitoring, homeland 

security, control, and communications. 


⦁ Micro pore optics 

⦁ Channeltron ® electron multipliers 

⦁ MAGNUM ® electron multipliers 

⦁ Long-Life microchannel plates 

⦁ Time-of-flight MCP detectors 

⦁ MCP detector assemblies 

⦁ FieldMaster ion guides and drift 

tubes 

⦁ Glass capillary arrays 

⦁ Resistive glass products 

⦁ Electron generator arrays 

⦁ MCP-based pmts 

⦁ Image intensifier tubes 

⦁ Intensified camera units 

⦁ Hybrid photo detectors 

⦁ Streak tubes 

⦁ High voltage power supplies 

⦁ Power tubes 

⦁ Neutron and gamma detectors 

⦁ Glass-coated wire 

⦁ Flexible fiber optics 

Facilities 

PHOTONIS in Sturbridge, Massachusetts 

manufactures Channeltron ® electron 

multipliers, microchannel plates, MCP 

detectors, ion guides, prototype detectors, 

and other custom glass products. 

The Lancaster, Pennsylvania facility 

manufactures power tubes and other 

related products. PHOTONIS in Roden, 

Netherlands manufactures image intensifier 

tubes, intensified camera units, 

and hybrid photo detectors. PHOTONIS 

in Brive, France manufactures image intensifier 

tubes and related products.


PIKE Technologies 

⦁ Automation and temperature control are 

available for many of our spectroscopy 

accessories to speed sampling and to provide 

precise thermal analysis. 


PIKE products are designed for spectrometers 

in the petrochemical, food, forensic, 

biochemical, pharmaceutical, semiconductor, 

agriculture, and material science 

industries. In addition, PIKE specializes 

in custom design of products for specific 

applications. PIKE products are designed 

and built with craftsmanship and care to 

exceed customer expectations. 

PIKE Technologies 

6125 Cottonwood Drive 

Madison, WI 53719 

TELEPHONE 

(608) 274-2721 

FAX 

(608) 274-0103 

E-MAIL 

sales@piketech.com 

WEB SITE 

www.piketech.com 


36 

YEAR FOUNDED 

1989 


PIKE Technologies was established in the summer of 1989, specializing 

in the development and manufacture of accessories and 

optical systems that enhance the performance of commercial 

spectrometers. 

PIKE concentrates on making the life of laboratory personnel 

easier. This is achieved through replacing traditional, tedious sampling 

routines with a range of innovative products and techniques. 


PIKE Products are designed to work with FTIR and UV-Vis spectrometers 

and are based upon the principles of transmission and 

reflection spectroscopy measurements. The sampling techniques 

offered can be divided into seven major groups: 

⦁ Attenuated total reflectance (ATR), for analysis of liquids, 

pastes, and soft solid materials 

⦁ Diffuse reflectance (DRIFTS), used in sampling of powders and 

solids 

⦁ Specular reflectance, useful in thin film composition and thickness 

measurements 

⦁ Microsampling products, FTIR microscope and beam 

condensers to analyze microsamples 

⦁ Integrating spheres, NIR, and Mid-IR versions for FTIR spectrometers 

⦁ Transmission supplies, including IR optics, and windows of all 

sizes and designs 


⦁ MIRacle — Patented “universal” sampling 

accessory — Diamond, ZnSe, Ge, Si, 

and AMTIR crystals 

⦁ GladiATR and GladiATR Vision— Highest 

performance diamond ATR 

⦁ VeeMax — Patented variable angle specular 

reflection and the ATR Max used for 

variable depth of penetration experiments 

and studies 

⦁ A wide range of fully automated FTIR, NIR, 

and UV-Vis products with easy to integrate 

AutoPRO software 

⦁ Valu-Line Kits combining the most often 

used sampling accessories and transmission 

kits containing sampling holders, 

cells, and optics 

⦁ Integrating spheres for IR and NIR 

Facilities 

PIKE Technologies is located in Madison, 

Wisconsin. Our products are fully compatible 

with all major brands of spectrometers 

and are sold directly, and through an 

extensive distributor network worldwide. 

Please visit our website for additional 

product and contact information.


Polymicro Technologies, 

A subsidiary of Molex Incorporated 


Polymicro Technologies, 

A subsidiary of Molex 

Incorporated 

18019 North 25th Avenue 

Phoenix, AZ 85023 

TELEPHONE 

(602) 375-4100 

FAX 

(602) 375-4110 

E-MAIL 

polymicrosales@molex.com 

WEB SITE 

www.polymicro.com 


115 

YEAR FOUNDED 

1984 


For over a quarter century, (since 1984), Polymicro Technologies 

delivers CREATIVE . . . INNOVATIVE . . . SOLUTIONS 

for the aerospace, analytical, astronomy, automotive, biodefense, 

biotechnology, communications, energy, manufacturing, 

medical, military, and pharmaceutical industries. 

Polymicro is the leader in providing specialty optical fibers 

and capillary tubing world wide. 


⦁ Spectroscopy, UV to mid-IR 

⦁ Sensors 

⦁ Analytical detectors 

⦁ Laser light delivery 

⦁ Remote illumination 

⦁ Astronomy spectral analysis 


Polymicro’s optical fiber, capillary tubing, fiber optic assemblies, 

and fiber and tubing arrays are commonly used in academic 

labs, national labs, and industry. Polymicro products 

find use in aerospace, analytical, astronomy, automotive, biodefense, 

biotechnology, communications, energy, manufacturing, 

medical, military, and pharmaceutical. Typical applications 

include spectroscopy, sensing, analytical detection and analysis, 

laser light delivery, remote illumination, process and quality 

monitoring and control, in addition to unique applications 

from astronomy and aerospace to your laboratory bench. 


Polymicro manufactures multimode, 

step-index fused silica optical fiber with 

polyimide, silicone, acrylate, and other 

buffers/coatings; hard clad optical fiber; 

dual clad optical fiber; highly stable deep 

UV optical fiber; broad spectrum optical 

fiber; fiber optic cables and assemblies; 

high-strength, high-temperature flexible 

fused-silica capillary tubing; light-guiding 

capillary; flow cells; square capillary 

tubing; windowed capillary tubes; UV 

transparent capillary; precision silica and 

quartz rods and “cleaved to length” tubing 

pieces; multilumen tubing; and microcomponents 

such as laser machined 

fiber tips, ferrules, sleeves, and laser cut 

rods or tubing. 

Facilities 

Polymicro has 50,000 sq. ft. of facility 

located in the North Phoenix area. At our 

location we have several draw towers 

that produce a large portion of capillary 

tubing and multimode step-index fibers 

used throughout the world. Polymicro 

has its own glass laboratory, assembly 

department, laser machining department, 

and sophisticated testing equipment to 

meet our customers’ needs for the highest 

quality products and service. 

To get your copy of our handbook or 

inquire about our products, simply e-mail 

our technical sales department at 

polymicrosales@molex.com. Or you can 

fax us at (602) 375-4110.


Specac, Inc. 


Specac delivers quality products engineered to meet your needs. Our accessories and systems are 

easy to use and built to last — from thin plastic film preparation accessories, used for routine quality 

checks, to sophisticated remote sampling systems for reaction monitoring. 

Specac is now part of Smiths Group, which acquired Specac Ltd from Graseby in 1997. Specac 

now employs around 55 people worldwide, with offices in the US and the UK, and a network of 

distributors and dealers worldwide. Smiths Group is an international company employing 16,000 

people in some 50 different businesses located in the UK, US, and Europe. 

Specac does not support chromatographic techniques. 


Specac provides accurate and reliable IR and FT-IR sample handling accessories to academic, 

industrial, and research institutions worldwide. Specific areas include oil refineries, petrochemicals, 

chemical, pharmaceutical, food, observatories, military, and universities. 

Specac Limited 

River House 

97 Cray Avenue 

Orpington 

Kent 

BR5 4HE 

United Kingdom 

TELEPHONE 

+44 01689 873134 

FAX 

+44 01689 878527 

Specac, Inc. 

50 Sharpe Drive 

Cranston, RI 02920 


Specac’s products fall into 4 areas: IR sampling accessories, sample preparation, polarizers, and 

products and process. 

We can provide everything you need, from classic hydraulic presses (up to 40 ton) to handheld 

dies for producing smaller samples, a grinding mill or a high-temperature constant thickness film 

maker system — whatever type of sample you are preparing, you can be sure of a perfect reading. 

Our range of gas cells allows us to offer sampling solutions in a wide variety of pathlengths, 

volumes, construction materials, and windows. 

Facilities 

Specac moved to its current purpose-built location in 1995, based in Orpington, Kent, UK. 

There has been a substantial manufacturing investment, and we have a team of optical and 

mechanical engineering experts using the latest in 3D CAD systems and optical design software. 

TELEPHONE 

(401) 854-5281 

FAX 

(401) 463-6206 

E-MAIL 

sales@specac.co.uk 

WEB SITE 

www.specac.com 


USA: 3 

UK: 55 

YEAR FOUNDED 

1971


Shimadzu Scientific Instruments 


⦁ Compact, high-resolution UV-1800 

⦁ Easy-to-use UVmini-1240 

⦁ Bioscience-oriented BioSpec-mini 

⦁ Micro-volume (1 μL to 2 μL samples) 

BioSpec-nano 

⦁ Single monochromator UV-2450 

⦁ Double-blazed, double monochromator 

UV-2550 

⦁ Research-grade UV-3600 UV-VIS-NIR 

⦁ SolidSpec-3700 UV-VIS-NIR 

Shimadzu Scientific 

Instruments 

7102 Riverwood Drive 

Columbia, MD 21046 

TELEPHONE 

(800) 477-1227 

(410) 381-1227 

FAX 

(410) 381-1222 

E-MAIL 

webmaster@shimadzu.com 

WEB SITE 

www.ssi.shimadzu.com 


USA: 335 

Worldwide: 9,600 

YEAR FOUNDED 

Shimadzu Scientific 

Instruments: 1975 

Shimadzu Corporation: 1875 


Shimadzu Scientific Instruments (SSI) is the North American 

subsidiary of Shimadzu Corp., headquartered in Kyoto, Japan. 

SSI was established in 1975 to provide analytical solutions to 

a wide range of laboratories in the Americas. With a vast installed 

base and preferred vendor status at many institutions, 

SSI’s instruments are used by top researchers across the globe, 

customers who can count on the stability, experience, and 

support only Shimadzu offers. 


⦁ UV–Vis 

⦁ FT-IR 


⦁ Atomic (AA/ICP) 

⦁ X-Ray (EDX/XRD/XRF) 

⦁ GC–MS 

⦁ LC–MS 


Shimadzu offers more spectroscopy instrumentation, with 

more software and accessory options, than any other company. 

This flexibility enables spectroscopists in virtually any 

laboratory, from biotechnology, pharmaceutical, and industrial 

to academic, forensic, and environmental, to select the instrument 

best suited to their application. Shimadzu provides free 

technical support for the life of the instruments and encourages 

customer alliances to further product development. 


Shimadzu meets your needs for ruggedness, ease of use, validation, 

and applications with a variety of UV–Vis spectrophotometers. 

FT-IR: Our robust, yet stable, FTIR spectrophotometers 

deliver optimum performance, 

sensitivity, and reliability at an 

exceptional price, and we offer more of the 

sampling accessories you need, including 

an automated microscope. 

FLUORESCENCE: High-performance spectrofluorophotometer 

handles a range of 

applications from routine analysis to highlevel 

R&D. 

AA/ICP: Simultaneous ICP and our series 

of high-quality AA spectrometers offer superior 

reliability, precision, sensitivity, and 

throughput to deliver maximum performance 

and value. 

X-ray: Our EDX/XRF/XRD systems are 

packed with powerful features to provide 

users with versatile, easy-to-use solutions. 

Facilities 

Shimadzu’s U.S. headquarters includes 

customer service and technical support, as 

well as a customer training and education 

center. Ten regional facilities, strategically 

located around the U.S., provide customers 

with local sales, service, and technical 

support.

www.ssi.shimadzu.com 

Explore The Full Spectrum Of Possibilities 

Count on Shimadzu Spectroscopy for a Variety of Applications 

From food, forensics and the environment to drug 

discovery, pharmaceuticals and more, Shimadzu can 

equip your laboratory with high-quality, cost-effective 

solutions for all of your analysis requirements. 

More Instruments, More Accessories, 

More Applications = More Solutions 

UV-VIS-NIR: Award-winning spectrophotometers: 

UV-Vis and UV-Vis-NIR that are rugged yet easy 

to use. Shimadzu’s proprietary UV Probe software 

provides powerful data manipulation capabilities. 

FTIR: Our robust, yet stable, FTIR spectrophotometers 

deliver optimum performance, sensitivity, and 

reliability at an exceptional price, and we offer 

more of the sampling accessories you need, 

like an automated microscope. 

Fluorescence: High-performance 

spectrofluorophotometer handles a range 

of applications from routine analysis to 

high-level R&D. 

AA/ICP: High-quality spectrometers 

represent the ultimate in 

technology by delivering 

exceptional performance and 

maximum value. 

X-ray: Our X-ray fluorescence 

spectrometers and X-ray 

diffractometers are packed with 

powerful features to provide users with 

versatile, easy-to-use solutions. 

You have demands. Shimadzu delivers. 

Learn more about Shimadzu’s spectroscopy products. 

Call (800) 477-1227 or visit us online at 

www.ssi.shimadzu.com/UV 

Order consumables and accessories on-line at http://store.shimadzu.com 

Shimadzu Scientific Instruments Inc., 7102 Riverwood Dr., Columbia, MD 21046, U.S.A.


SPEX CertiPrep 


SPEX CertiPrep 

203 Norcross Ave. 

Metuchen, NJ 08840 

TELEPHONE 

(800) 522-7739 

FAX 

(732) 603-9647 

E-MAIL 

CRMsales@spexcsp.com 

WEB SITE 

www.spexcertiprep.com 


50 

YEAR FOUNDED 

1954 


SPEX CertiPrep is a leading manufacturer of certified reference 

materials (CRMs) and calibration standards for analytical spectroscopy 

and chromatography. We offer a full range of organic 

and inorganic CRMs for ICP, ICP-MS, AA, GC, GC–MS, and 

HPLC. We are certified by UL-DQS for ISO 9001:2008 and are 

proud to be accredited by A2LA for both organic and inorganic 

CRMs under ISO 17025:2005 and ISO Guide 34-2000. The 

scope of our accreditation is the most comprehensive in the 

industry and encompasses all our manufactured products. We 

also offer laboratories the option to create their own custom 

standards with quick turnaround time at no additional cost. 


⦁ ICP 

⦁ ICP-MS 

⦁ IC 

⦁ AA 

⦁ ISE 

⦁ XRF 

⦁ XRD 

⦁ GC 

⦁ GC–MS 

⦁ HPLC 


SPEX CertiPrep supplies certified reference materials to laboratories 

worldwide in the following markets: research and development 

laboratories, environmental laboratories, wastewater 

treatment facilities, cement facilities, state and federal government 

agencies, industrial laboratories, manufacturing facilities, 

clinical laboratories, colleges and universities, 

public utilities, oil refiners, nuclear 

plants, winery, wastewater and drinking 

water labs, and more. 


SPEX CertiPrep’s products include aqueous 

and organometallic certified reference 

materials for ICP-MS, ICP, and AA; organic 

standards for GC, GC–MS, and HPLC; ion 

chromatography and ion selective electrode 

standards; inorganic and organic 

quality control samples; and fusion fluxes 

and additives for XRF analysis. We also 

manufacture a line of contamination control 

products including sub-boiling acid 

stills, a pipette washer, and OdorEroder 

odor control products. Our newest product 

offering includes a line of pure and 

ultra-pure fusion fluxes and additives. Our 

services include shipment of stock items 

within 24–48 hours from our Metuchen, 

New Jersey facility. Technical customer 

service is available Monday through Friday 

8:00 am – 5:30 pm EST. Live chat, along 

with our complete product catalog and a 

technical knowledge base is also available 

at our newly redesigned website: 

www.spexcertiprep.com. 

Facilities 

Our US headquarters is located in 

Metuchen, New Jersey. All our products are 

manufactured and shipped from this facility. 

SPEX CertiPrep, Ltd. is the European 

subsidiary of SPEX CertiPrep, Inc. and is 

located in Middlesex, England. Distributors 

throughout Europe support this branch.

All your CRM needs, 

right where you need them. 


Our newly redesigned Web site puts 

CRM resources at your fingertips. 

For more than half a century, SPEX CertiPrep has been providing superior 

Certified Reference Materials (CRMs) for spectroscopy and chromatography, 

offering an unparalleled selection of inorganic and organic standards. 

Now, our redesigned Web site offers the information and resources you 

need on our products, all in one place: 

: : Easy ordering system : : Live chat 

: : Technical literature : : Trade show information 

: : “Ask a chemist” : : Enhanced product search 

: : Custom standard request : : E-newsletter 

And much more! Visit us at www.spexcertiprep.com. 

203 Norcross Avenue 

Metuchen, NJ 08840 


E-mail: crmsales@spexcsp.com 

Phone: 1-800-LAB-SPEX 

Fax: 732-603-9647 

© SPEX CertiPrep, Inc. 2010 

WA-10A


Spellman High Voltage Electronics 



We offer power supplies with well regulated outputs from 


Teledyne Leeman Labs 

Teledyne Leeman Labs 

6 Wentworth Drive 

Hudson, NH 03051 

TELEPHONE 

(603) 886-8400 

FAX 

(603) 886-9141 

E-MAIL 

leemanlabsinfo@teledyne.com 

WEB SITE 

www.teledyneleemanlabs.com 


60 

YEAR FOUNDED 

1981 

Company 

Description 

Since its founding 

in 1981, Teledyne 

Leeman Labs has 

been an innovator in 

atomic spectroscopy 

and introduced many 

concepts that are now 

considered industry 

standards. Among 

these were the first use of an echelle spectrometer for ICP-OES 

and the first fully automated mercury analyzers. 

Now a leading supplier of instruments for elemental analysis, we 

take great pride in the quality and value of our products and the 

depth of our commitment to customer satisfaction. 


⦁ Inductively coupled plasma (ICP) spectrometers 

⦁ DC Arc spectrometers 

⦁ Mercury analysis 


Leeman Labs’ products are used in applications essential to QA/ 

QC, environmental analysis, R&D, and process control. They are 

used in industries including: aerospace, agriculture, automotive, 

beverage, biofuels, chemicals and petrochemicals, clinical, 

electronics, environmental/contract labs, foods/food processing, 

forensics, geological, hazardous waste, metals manufacturing, 

mining, nuclear, petroleum/gas, pharmaceutical/supplements, 

power generation, soils, wastewater, and wear metals/oils. 


Inductively coupled plasma (ICP) spectrometers: 

Prodigy ICP brings together a state-of-the-art, large format, 

programmable array detector (L-PAD) with an advanced high 

dispersion Echelle spectrometer to provide exceptional analytical 

performance. Prodigy is our most powerful and versatile ICP 

spectrometer. Prism ICP is a high performance cost effective 

simultaneous array detector ICP. Designed for practicality and 

performance, Prism is a great solution for many QA/QC and 

environmental analysis applications. Profile Plus 

ICP is a great stepup 

from atomic absorption spectrometers and is a cost effective 

solution for labs with limited sample loads. 

Mercury Analyzers: Hydra II AA 

operates on the principle of cold 

vapor atomic absorption (CVAA) to provide the analyst with a 

1 ppt detection limit as well as compatibility with an extremely 

wide range of sample matrices. Hydra II AF 

operates on the principle 

of cold vapor atomic fluorescence (CVAF) and is available in 

two configurations. The first is the core Hydra II AF 

which provides 

a detection limit of 0.1 ppt and a dynamic 

range that extends to the high ppb level. For 

laboratories that require even lower limits of 

detection, the Hydra II AFGold 

includes a gold 

amalgamation system to preconcentrate 

mercury and yield a limit of detection well 

below 0.05 ppt. Hydra-C operates on the 

principle of thermal decomposition with 

atomic absorption detection to facilitate the 

direct analysis of solid or liquid samples. 

Hydra-C is designed to address the needs of 

analysts who want to use EPA method 7473 

or who simply want to determine mercury 

without having to digest their samples. 

DC Arc Spectrometer: Prodigy DC Arc is 

designed for fast, quantitative elemental 

analyses of difficult to dissolve samples. 

Prodigy DC Arc performs elemental analysis 

of samples in their native form without 

sample digestion. Few other techniques can 

challenge the ease-of-use or productivity of 

DC Arc when it comes to samples that are 

difficult or impossible to digest. 

Inorganic Standards and Reagents: 

Plasma-Pure Standards: Single and Multielement 

standards for AA, ICP, and ICP-MS 

as well as high purity reagents for mercury 

analysis. 

Facilities 

Teledyne Leeman Labs is located in Hudson, 

New Hampshire. The facility offers both 

training and demonstration areas to better 

serve our customer base. Sales offices and 

representatives are located worldwide to 

provide sales, service, and support on all our 

instrumentation.


Thermo Fisher Scientific 



Our growing portfolio of products includes 

innovative technologies for a multitude 

of markets including food safety, environmental 

testing, materials science, and 

pharmaceutical. 


Thermo Scientific spectroscopy instruments 

are ideal for investigative analysis 

or quality control applications. 

Spectroscopy systems are used to determine 

the molecular or elemental composition 

of a wide range of complex samples, 

including liquids, solids, and gases. We offer 

an expansive range of techniques, such 

as FT-IR, FT-NIR, infrared microsampling, 

Raman spectroscopy, AA, ICP, ICP-MS and 

ARL OES, XRD and XRF spectrometers. 

Thermo Fisher Scientific 

Instruments 

5225 Verona Road 

Madison, WI 53711 

TELEPHONE 

(800) 532-4752 

FAX 

(608) 273-5046 

E-MAIL 

analyze@thermofisher.com 

WEB SITE 

www.thermoscientific.com 


Thermo Fisher Scientific is the world leader in serving science, 

enabling our customers to make the world healthier, cleaner, 

and safer. Our goal is to make our customers more productive 

and to enable them to solve their analytical challenges, 

from routine testing to complex research and discovery. We 

offer a wide range of products including analytical instruments, 

equipment, reagents and consumables, software, and 

services for research, analysis, discovery, and diagnostics. Our 

manufacturing sites in the United States and Europe provide 

products for customers within pharmaceutical and biotech 

companies, hospitals and clinical diagnostic labs, universities, 

research institutions, and government and environmental 

industries. 


⦁ AA 

⦁ ICP 

⦁ ICP-MS 

⦁ Combustion analyzers 

⦁ FT-IR 

⦁ FT-NIR 

⦁ UV-Vis 

⦁ Raman 

⦁ EDS/WDS/EBSD 

⦁ OES 

⦁ XRD 

⦁ XRF

© 2009 Thermo Fisher Scientific Inc. All rights reserved. All trademarks are the property of Thermo Fisher Scientific Inc. 

and its subsidiaries. 

Surprising performance – 

200W performance from 50W power. 

Get surprised by the Thermo Scientific ARL OPTIM’X XRF Analyzer 

delivering performance beyond your expectations due to our unique 

UCCO Ultra Closely Coupled Optics technology 

• Innovative UCCO technology combined with SmartGonio and/or 

MultiChromators to achieve highest sensitivity 

• 200W equivalent analytical performance from 50W X-ray power 

• Pre-calibrated turn key packages for cement, slags or petroleum 

analysis 

• Capability of multi-matrix fluorine to uranium analysis using 

OptiQuant standard-less program 

• Lowest cost of ownership thanks to low operating cost, highest 

reliability and minimal auxiliary equipment 

Visit www.thermoscientific.com/optilab for 

more information on the new generation of 

Thermo Scientific ARL OPTIM'X XRF Analyzer. 

Join the large number of users that benefit from the extreme 

reliability and stability of our ARL OPTIM’X spectrometer. 

You’ll be surprised by the price too! 

E-mail: analyze@thermo.com 

Moving science forward 

Part of Thermo Fisher Scientific


WITec GmbH 


WITec GmbH 

Main Address: 

Lise-Meitner-Str. 6, 89081 

Ulm, Germany 

WITec Instruments Corp. 

200 East Broadway Ave. 

Suite 30, Maryville, TN 37804 

TELEPHONE 

+49 (0) 731 140 700 

USA: (865) 984-4445 

FAX 

+49 (0) 731 140 7020 

USA: (865) 984-4441 

E-MAIL 

info@witec.de 

WEB SITE 

www.witec.de 


33 

YEAR FOUNDED 

1997 


WITec is a manufacturer of high-resolution optical and scanning 

probe microscopy solutions for scientific and industrial 

applications. A modular product line allows the combination 

of different microscopy techniques such as Raman, NSOM, or 

AFM in one instrument. The company’s product line features 

a near-field scanning optical microscope, using unique cantilever 

technology, a confocal raman microscope designed for 

highest sensitivity and resolution, and an AFM for material 

research and nanotechnology. Focusing on innovations and 

constantly introducing new technologies, WITec is the leading 

expert for a vide variety of optical, structural, and chemical 

imaging tasks. 



⦁ Confocal raman imaging 

⦁ Ultrafast confocal raman imaging 

⦁ Confocal and near-field fluorescence spectroscopy 

⦁ Upgradeable with atomic force and near-field microscopy 

capabilities 


WITec products are delivered worldwide to academic and 

industrial research labs focusing on high-resolution chemical 

imaging and materials characterization. Areas of application 

for WITec’s confocal raman imaging systems include polymer 

sciences, pharmaceutics, life science, geoscience, thin films 

and coating analysis, semiconductors, and nanotechnology. 


WITec alpha300 Confocal Raman 

Microscope: The alpha300 R is a Raman 

imaging system focusing on high-resolution 

as well as high-speed spectra and image 

acquisition. The acquisition time for a single 

Raman spectrum is in the range of one millisecond 

or even below; thus, a complete Raman 

image consisting of tens of thousands 

of spectra can be obtained in one minute or 

less. Differences in chemical composition, 

although completely invisible in the optical 

image, will be apparent in the Raman image 

and can be analyzed with a resolution down 

to 200 nm. 

WITec alpha500 Automated Confocal 

Raman & Atomic Force Microscope: The 

alpha500 is an automated Confocal Raman 

and atomic force microscopy system 

incorporating a motorized sample stage 

for large samples and customized multiarea/multi-point 

measurements. It allows 

nondestructive chemical imaging with 

Confocal Raman Microscopy as well as 

high-resolution topography imaging with 

AFM using the integrated piezo scan-stage. 

Both modes can be run fully automatically, 

guaranteeing the most comprehensive 

surface inspection possibilities for systematic 

and routine research tasks or highlevel 

quality control. 

Facilities 

WITec Headquarters is located in Ulm, 

Germany, and includes the R&D department, 

production, sales & marketing, and 

administration. WITec Instruments Corp. 

in Maryville, Tennessee, is responsible for 

North American sales and service activities.


XOS 


End users such as refiners, manufacturers, and third party test 

labs in the energy and consumer products markets implement 

XOS analyzers to drive yield and throughput improvements, 

meet strict regulatory requirements, and enhance 

product quality. Regulators use XOS analyzers to enforce 

environmental and consumer safety regulations. Instrument 

designers and end users in government, universities, and industrial 

laboratories call on XOS expertise 

in X-ray optics, systems, and application 

engineering, from design to complete engine 

design. 


Application-specific analyzers for measurement 

of regulated elements including 

lead, cadmium, chlorine, and sulfur. Features 

include peak detection performance, 

low maintenance, and user-friendly operation 

in laboratory, at-line, on-line, and 

in-the-field environments. Lines include 

SINDIE (sulfur); CLORA (chlorine); SIGNAL 

(silicon); and HD XRF analyzers (e.g. for 

lead and other regulated elements in consumer 

products). 

XOS 

15 Tech Valley Drive 

East Greenbush, NY 12061 

TELEPHONE 

( 518) 880-1500 

FAX 

( 518) 880-1501 

E-MAIL 

info@xos.com 

WEB SITE 

www.xos.com 

YEAR FOUNDED 

1990 


XOS is a leading global provider of mission-critical, materialsanalysis 

equipment and components for industries and regulators 

that must control material quality and performance, 

from consumer products (e.g. toys, electronics) to energy 

(e.g., petroleum) industries. XOS provides a wide range of 

portable, bench-top, and on-line elemental composition 

analyzers for field, laboratory, and process applications. XOS 

leverages its technology leadership in X-ray optics to supply 

application-specific analyzers that measure environmental 

and product contaminants such as lead, cadmium, chlorine, 

and sulfur. As a supplier to analytical instrument companies, 

XOS also offers X-ray optics and sub-systems to enhance analytical 

performance in X-ray instruments. 


⦁ Monochromatic XRF, MWDXRF, HD XRF 

⦁ EDXRF 

⦁ WDS, EDS 

⦁ Confocal XRF 

⦁ XRD, wXRD 

X-ray optics for applications including 

material composition and thin film analysis; 

and material stress, strain, structure, 

phase, and texture. XOS is the leading 

global manufacturer of Capillary Optics 

and Doubly Curved Crystal Optics for X-ray 

analytical instrumentation, including X-ray 

fluorescence, X-ray diffraction, and electron 

beam systems. 

Facilities 

XOS, headquartered near Albany, New 

York, has an established national and 

international presence by partnering 

with well-established instrument manufacturers; 

and also through established 

distribution partners who are the most 

experienced and respected in the relevant 

markets. XOS maintains satellite offices 

including in Shenzhen, China.

86 Biological Molecular Spectroscopy 

APPLICATION NOTES – DECEMBER 2010 

Portable Transmission FTIR Analysis of Volatile Samples Using 

the DialPath Liquid Cell 

Frank Higgins, A2 Technologies 

Traditionally the analysis of volatile liquids by FTIR 

spectroscopy has always entailed a sealed fixed pathlength 

cell. This technique is widely used for quantitative 

analysis of analytes in volatile solvents with applications 

in the fuel, chemical, and pharmaceutical industries. Use 

of sealed cells requires a skilled user to add the sample to 

the cell by syringe, taking great care to avoid air bubbles 

or incomplete filling of the cell. Improper filling can also 

cause damage to sealed cells by breaking the window or 

amalgam seal with excess pressure. These cells are also 

prone to internal reflections that cause significant spectral 

artifacts called “fringing” and baseline noise features 

from improper cell fitment into the spectrometer. These 

drawbacks lead to methods developed with less precision 

and accuracy, limiting the utility of the analysis. A2 Technology’s 

patented Dialpath liquid cell systems are simple 

to both fill and clean, eliminate spectral artifacts and still 

provide precise and accurate sample measurement for volatile 

samples and solvents. 

In this application brief, we will demonstrate that the 

open cell design of the DialPath technology is effective 

with samples that contain either volatile solutes and/or 

volatile solvents. The study will illustrate that evaporation 

does not change the sample concentration, during typical 

measurement times on the ML analyzer. The experiments 

in this work were designed to determine the effect of evaporation 

on quantitative measurements using the TumblIR 

liquid cell. The results of two experiments, which test the 

effects of evaporation and diffusion on calibrated methods 

for dioctyl phthalate (DOP, non-volatile analyte) in tetrahydrofuran 

(THF, volatile solvent) and benzene (highly 

volatile analyte) in hexane (volatile solvent), are presented. 

Results 

Analytical standards of dioctylphthalate (DOP) in THF 

were prepared volumetrically in the 0–5% range, and the 

FTIR spectra collected on a ML FTIR analyzer with Dial- 

Path Technology. The spectra of the standards were measured 

in triplicate collecting 64 scans at 8 cm -1 resolution, 

Figure 1: The DOP vol% results from replicate measurements 

at increasing delays from sample introduction to DialPath cell 

and sample scan initialization. The red line is the mean measured 

DOP concentration with no time delay, and the ±2% relative error 

from mean time 0 is shown as purple lines. 

yielding an 18 s scan time. A quantitative calibration was 

developed using partial least squares (PLS) modeling of 

the DOP ester absorbance region; two loading vectors were 

used. The standard error of cross validation (SECV) for 

this method was 0.012% DOP; the actual versus predicted 

correlation coefficient (R 2 ) was 0.9999. This method is 

loaded into the A2 Technologies MicroLab PC software. 

Samples of DOP in THF at 0.5% nominal concentration 

were prepared volumetrically. The samples were 

prepared with low volumes for convenience and are only 

meant to test the repeatability of the instrument and method. 

The 0.5% sample was measured with the same method 

parameters (18 s scan time) with increasing delays from 

sample introduction to the start of scanning. Each sample 

was introduced with the cell in the closed position using 

plastic transfer pipettes (the solvent wicks into the cell very 

easily) and the cell was completely filled (~250 μL). Since 

the solvent is the volatile component, the effects due to 

evaporation would increase the DOP concentration. Figure 

1 shows the replicate measurements of samples 0, 30, 

60, 120, and 300 s delay. The mean value for the 0 s delay

APPLICATION NOTES – DECEMBER 2010 Molecular Spectroscopy Biological 87 

is plotted as the red line and the 2% error limits are plotted 

as the two purple lines. The measured DOP concentration 

didn’t exceed the 2% relative error until the 300 s delay 

time was reached. Even at a 2 min delay, little effect of the 

evaporation can be observed. Clearly, evaporation poses no 

issues to these measurements using the DialPath sample 

interface with measurement times of up to 2 min. 

The second experiment involves a volatile solvent (hexane) 

and a highly volatile solute (benzene), and represents 

the worst case scenario for evaporation effects on quantitative 

analysis. A PLS model was created using the benzene 

ring in-plane bend absorbance at 670 cm -1 . The model used 

one loading vector, had an SECV of 0.0076% benzene and 

the actual versus predicted had a correlation of 0.996. A 

nominal 0.5% benzene in hexane sample was prepared 

and used to test the repeatability at 0, 45, and 60 s delay 

between sample introduction and measurement. Figure 2 

shows the results of each measurement as well as the average 

value of the 0 s delay samples as the red line and the 

2% relative error levels as the orange line. Only a single 

measurement of the 60 s delay showed greater than 2% 

relative error. These results indicate that analysis times of 

up to 60 s have no appreciable affect on measurement accuracy, 

even for highly volatile samples. 

Due to the A2 Technologies fast scanning FTIR technology 

and the much slower rate of diffusion, there is no 

observed effect of evaporation in the normal 18–45 s scan 

time used for DialPath methods. The shape and configuration 

of the DialPath cell, Figure 3, also minimizes the effects 

of evaporation. The 100 μm pathlength active region 

between the top and bottom cell window is filled with only 

5 μL of solvent, whereas the typical total fill volume for 

the cell is 250 μL. This large difference between sampled 

and bulk cell volume, coupled with the distance that the 

diffusion gradient has to travel before reaching the inner 

sampling region, explains why there are no significant effects 

of solvent or solute diffusion or evaporation observed 

using the DialPath cell. 

Conclusions 

This application note has shown that there is no effect on 

the accuracy or precision of quantitative methods when 

measuring samples with volatile solvents or analytes on 

the TumblIR or Dialpath transmission cells. No effect was 

seen with methods up to 60 s in length; the PAL spectrometer 

can measure 140 scans in 60 s at 4 cm -1 resolution. 

The ease of use and simplicity of the TumblIR technology 

makes it ideal for many liquid applications including gasoline, 

ethanol, reaction monitoring, or solvent extraction. 

Figure 2: The benzene vol% results from replicate measurements 

at increasing delays from sample introduction to the Dial- 

Path cell and sample scan initialization (18 s). The red line is the 

mean measured benzene % concentration with no time delay, 

and the ±2% relative error from mean time 0 is shown as purple 

lines. 

Figure 3: The iPAL FTIR spectrometer equipped with the TumblIR 

cell (left) and the expanded sample interface region of the 

cell (right). The relatively small “active region” (5 μL fill area) in 

proportion to the total filled cell volume minimizes the effects of 

evaporation and diffusion in the 18-45 s time scale. 

The precision of the TumblIR along with the lack of interference 

fringing and baseline effects provides methods 

with better accuracy than previously obtainable using infrared 

spectroscopy. 


14 Commerce Drive, Danbury, CT 06810 

tel. (203) 312-1100; Fax (203) 312-1058 

Website: www.a2technologies.com

88 Chiral Molecular Spectroscopy APPLICATION NOTES – DECEMBER 2010 

Long-Wavelength Dispersive 1064nm Raman: 

Non-Invasive Cancer Tissue Diagnostics 

BaySpec, Inc. 

Overcoming fluorescence background noise in cancerous 

biological tissue samples achieved by using 

Dispersive 1064nm Raman excitation instruments. 

It has been documented that Raman spectroscopy is an effective 

technique for detecting molecular changes associated 

with cancer; however, it is well-known that fluorescence found 

in biological samples generates significant noise complicating 

specificity in distinguishing between normal and cancerous 

tissue (1). 

Raman scattering is a spectroscopic technique capable of 

providing highly detailed chemical information about a tissue 

sample. In contrast to other optical spectroscopic techniques, 

there are a large number of Raman-active molecules in tissue 

and their spectral signatures are sharp and well delineated. 

The earliest Raman spectroscopy techniques utilized Fourier 

transform (FT)–Raman spectroscopy, a method that measures 

Raman spectra with high signal-to-noise ratio (S/N) and 

minimal fluorescence interference and has been used for many 

in vitro applications. However, long integration times and 

bulky instrumentation negate this technique for in vivo use. 

Early attempts at measuring Raman spectra of tissue were 

difficult because of the fluorescent nature of tissue and limitations 

of sources and detectors. Today, because of the telecom 

boom and bust, there has been a Manhattan Project effect on 

the development of lasers and optical components. Ten years 

ago, optics, lasers, and detectors were limited to laboratories 

on bulky optical benches with sophisticated liquid nitrogen 

cooling and complicated alignment/operations requiring a 

PhD to operate. 

Current chemometric methods rely on mathematical techniques 

such as the use of second derivatives, Fourier filtering, 

and polynomial fitting to remove the fluorescence background. 

Classification algorithms are developed using a variety 

of multivariate statistical methods such as linear and nonlinear 

discrimination analysis, neural networks, genetic algorithms, 

and cluster analysis. The resulting end goal is to obtain high 

sensitivity and specificity in the recognition of a target condition 

amidst a variety of tissue categories depending upon the 

tissue type. 

Today, without sacrificing performance in many cases, 

lasers are the size of your little finger; Newton’s prism has been 

replaced by a high-throughput holographic volume phase 

Figure 1: Raman spectra of normal human kidney tissue and 

cancerous tissue. 

grating; and detectors can be thermoelectrically air-cooled, 

doing away with liquid nitrogen. Using low-profile, surfacemount 

electronics completes the picture, enabling spectrometers 

the size of your Blackberry or iPhone. 

Therefore, for the first time, a ruggedized no moving parts 

dispersive long-wavelength 1064 nm Raman spectroscopy in 

conjunction with multivariate statistical technique has the potential 

for rapid in vivo diagnosis of benign and malignant 

tissues based on the optical evaluation of spectral features of 

biomolecules. 

For more information contact us at info@bayspec.com. 

References 

(1) A. Mahadevan-Jansen, Biomedical Photonics Handbook, 

T. Vo-Dinh, Ed. (CRC Press, Washington, D.C., 2003), pp. 30:1– 

30:27. 

(2) Charge-Transfer Devices in Spectroscopy, J.V. Sweedler 

(Editor), Kenneth L. Ratzlaff (Editor), B.M. Denton 

(Editor), published by John Wiley & Sons, Inc., March 1994. 

BaySpec, Inc. 

1101 McKay Drive, San Jose, CA 95131 

tel. (408) 512-5928 

Website: www.bayspec.com 

Email: info@bayspec.com

APPLICATION NOTES – DECEMBER 2010 

Molecular Spectroscopy 89 

Determination of Low Concentration Methanol in Alcohol 

by an Affordable High Sensitivity Raman Instrument 

Duyen Nguyen and Eric Wu, Enwave Optronics, Inc. 

Low concentration natural methanol exists in most alcoholic 

beverages and usually causes no immediate health 

threat. Nevertheless, it is possible to have natural occurring 

methanol in beverages with concentration as high as 18 grams 

per liter of ethanol; or equivalent to 0.72% methanol in 40% 

ethanol, in alcohol (1). Current EU regulation limits naturally 

occurring methanol to below 10 grams per liter of ethanol; 

or equivalent to 0.4% methanol in 40% ethanol. 

Raman spectroscopy has been shown to be an effective tool 

in compositions analysis as well as adulteration identifications in 

foods (2). In the alcoholic beverage industry, the standard composition 

analysis method were more expensive and time-consuming 

gas chromatography (3). Here, we present a Raman spectroscopy 

method for a quick and lower cost alternative to verify the 

existence of low concentration methanol in alcohol. 

Experiment 

40% ethanol/water solution was prepared using 200-proof 

ethanol and distilled water. HPLC grade methanol 

was added into the 40% ethanol solution to make 

samples with methanol concentration ranging from 

50 ppm to 2.5%. An Enwave Optronics’ ProRaman instrument 

with laser excitation at 785 nm was used for the measurements. 

The sample solutions were measured in quartz cuvette 

in a sample holder. Figure 1 depicts the results of the measured 

spectra in the fingerprint region of the Raman spectra. 

Partial least square (PLS) regression method was used for 

calibration and prediction model for methanol. The spectral 

region from 950–1200 cm -1 was chosen for developing the 

calibration model. The actual vs. predicted concentration 

value of methanol is shown in Figure 2. It is shown that the 

measured data and PLS prediction match very well with correlation 

coefficient R 2 @ 0.997. 

Conclusion 

An affordable, high sensitivity ProRaman instrument was used 

with PLS method to successfully analyze low concentration methanol 

in 40% alcohol. Based on our findings, the detection limit for 

methanol in 40% of ethanol is much better than 50 ppm and reliable 

quantitative determination using PLS prediction could reach 

50 ppm of methanol in 40% alcohol. 

References 

(1) Bindler F., Voges E., Laugel P. “The problem of methanol concentration 

admissible in distilled fruit spirits.” Food Addit Contam 1988: 5: 343–351. 

Figure 1: The fingerprint range spectra of the various solutions. 

Figure 2: Actual and predicted methanol concentrations using 

PLS regression model. 

(2) Mackenzie, W.M. and Aylott, R.I. “Analytical strategies to confirm 

Scotch whisky authenticity.” The Analyst (2004), 129 : 607–612. 

(3) Reid, L.M., O’Donnell, C.P., Downey, G. “Recent technological 

advances for the determination of food authenticity.” Trends in Food 

Science & Technology (2006), 17: 344–353. 


18200 McDurmott St., Suite B, Irvine, CA 92614 

tel. (949) 955-0258; fax (949) 955-0259 

Website: www.enwaveopt.com

90 Molecular Spectroscopy APPLICATION NOTES – DECEMBER 2010 

High-Resolution NIR Analysis 

R. Morris, Ocean Optics, Inc. 

New detector and optical bench options make it possible 

to configure near-infrared spectrometer setups 

for high-resolution applications such as laser and optical 

fiber characterization. Our NIRQuest-series spectrometers 

cover various segments of the 900–2500 nm 

region and serve a variety of application needs. 

Near-infrared spectroscopy is a common analytical technique 

for chemistry and process control, where typical applications 

include identiffcation of species and determination 

of water and fat content. In applications like those, absorbance 

peaks are often broad and optical resolution requirements of 

lesser concern than performance parameters such as low noise 

and high sensitivity. 

Yet there also are number of NIR applications where optical 

resolution of

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