Wetenschappelijk jaaroverzicht 2012 - Catharina Ziekenhuis

RESULTS: For the majority of biomarkers, we observed lower levels in the healthy control
group compared with patients with stable angina who underwent coronary catheterization.
We found no difference for any of the selected biomarkers between patients with a positive
FFR (d 0.75) and negative FFR (>0.80). We observed no relationship between the
investigated biomarkers and FSS.
CONCLUSION: The presence of local atherosclerotic lesions that result in inducible
myocardial ischemia as measured by FFR in patients with stable coronary artery disease is
not associated with increased plasma levels of IL-6, IL-8 and TNF- or increased expression of
TLR2 and TLR4, CD11b, CD62L and CD14 on circulating leukocytes.
Impactfactor: --
Sels JE
Functional measurement of coronary stenosis
Pijls NH*, Sels JW*
J Am Coll Cardiol. 2012 Mar 20;59(12):1045-57
Voor abstract zie: Cardiologie - Pijls NH
Impactfactor: 14.156
Tonino WA
Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease
De Bruyne B, Pijls NH*, Kalesan B, Barbato E, Tonino PA*, Piroth Z, Jagic N, Möbius-
Winkler S, Rioufol G, Witt N, Kala P, MacCarthy P, Engström T, Oldroyd KG, Mavromatis
K, Manoharan G, Verlee P, Frobert O, Curzen N, Johnson JB, Jüni P, Fearon WF; FAME 2
Trial Investigators
N Engl J Med. 2012 Sep 13;367(11):991-1001
Voor abstract zie: Cardiologie - Pijls NH
Impactfactor: 53.298
Tonino WA
The impact of sex differences on fractional flow reserve-guided percutaneous
coronary intervention: a FAME (Fractional Flow Reserve Versus Angiography for
Multivessel Evaluation) substudy
Kim HS, Tonino PA*, Bruyne B de, Yong AS, Tremmel JA, Pijls NH*, Fearon WF; FAME
Study Investigators
JACC Cardiovasc Interv. 2012 Oct;5(10):1037-42
OBJECTIVES: This study sought to evaluate the impact of sex differences on fractional flow
reserve (FFR)-guided percutaneous coronary intervention (PCI).
BACKGROUND: The FAME (Fractional Flow Reserve Versus Angiography for Multivessel
Evaluation) study demonstrated that FFR-guided PCI improves outcomes compared with an
angiography-guided strategy. The role of FFR-guided PCI in women versus men has not been
evaluated.
METHODS: We analyzed 2-year data from the FAME study in the 744 men and 261 women
with multivessel coronary disease, who were randomized to angiography- or FFR-guided PCI.
Statistical comparisons based on sex were stratified by treatment method.
RESULTS: Although women were older and had significantly higher rates of hypertension
than men did, there were no differences in the rates of major adverse cardiac events (20.3%
vs. 20.2%, p = 0.923) and its individual components at 2 years. FFR values were significantly
higher in women than in men (0.75 ± 0.18 vs. 0.71 ± 0.17, p = 0.001). The proportion of
51