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Great Equalization: Is MBBS From India Equal To M.D. In U.S.A?

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AAPI Journal • March 2009<br />

SPECIAL ARTICLE<br />

Probiotic Theraphy<br />

Continued from page 27<br />

disaccharide lactose into the<br />

simple sugars glucose and<br />

galactose in the Ileum, and thus<br />

reduce the discomfort of lactose<br />

intolerance.<br />

2. Reduction of intestinal<br />

infections: Antibiotic-induced<br />

diarrhea has been successfully<br />

controlled by Probiotics.<br />

Lactobacillus and<br />

Bifidobacterium have been used<br />

in children and adults for<br />

therapy of intestinal infections.<br />

3. Reduction of coronary heart<br />

disease: The fact that Probiotic<br />

supplementation inhibits<br />

cholesterol concentrations in the<br />

blood and increases the<br />

excretion of cholesterol in the<br />

feces has been well<br />

documented. Cholesterol<br />

absorption is interfered within<br />

the gut partly due to<br />

assimilation of cholesterol by<br />

Probiotic organisms. <strong>In</strong> addition,<br />

Probiotics (Bifidobacterium<br />

longum) deconjugate bile salts<br />

with the aid of bile salt<br />

hydrolase, and thus increase the<br />

excretion of free bile salts in the<br />

feces. This has the potential to<br />

reduce serum cholesterol<br />

because the replacement of bile<br />

salts would require the<br />

utilization of some cholesterol<br />

in the body. Thus, the resultant<br />

hypocholesterolemia may<br />

reduce the incidence of<br />

coronary heart disease.<br />

4. Immunomodulation: This is a<br />

very important activity induced<br />

by Probiotics. Immunestimulating<br />

activity is attributed<br />

to their bacterial cell envelope<br />

constituents such as<br />

peptidoglycan. Results of<br />

various investigators indicate<br />

that Probiotics stimulate the<br />

28 www.aapiusa.org<br />

production of antibodies,<br />

enhance the systemic activity of<br />

macrophages, and increase<br />

interferon levels and the number<br />

of killer cells.<br />

5. Suppression of cancer: Dietary<br />

intake of lyophilized cultures of<br />

Bifidobacterium longum has<br />

significantly suppressed the<br />

development of azoxymethaneinduced<br />

aberrant crypt foci<br />

(ACF) formation in the colon.<br />

The same group of scientists<br />

elucidated the ability of the<br />

Probiotic strain to inhibit the<br />

incidence of colon tumors.<br />

6. Suppression of Helicobacter<br />

pylori: Helicobacter pylori is a<br />

gram-negative spiral-shaped<br />

bacterial pathogen that<br />

colonizes in the area between<br />

the mucous layers of the<br />

stomach and gastric epithelium.<br />

The <strong>In</strong>ternational Agency for<br />

Research on Cancer has<br />

classified H. pylori as a Group I<br />

carcinogen. This is the first<br />

pathogenic bacterium to be<br />

classified as such. Limited<br />

research data indicate that even<br />

H. pylori can be inactivated or<br />

suppressed with the use of<br />

proper Probiotics.<br />

Prophylactic Probiotic Therapy for<br />

Cancer Suppression:<br />

Some of the non-Probiotic type of<br />

gastrointestinal flora will convert<br />

procarcinogens to carcinogens. Some<br />

of the end products of digestion are<br />

procarcinogenic. For example, end<br />

products of the digestion of beef may<br />

be more procarcinogenic than those<br />

of vegetables. Procarcinogenic<br />

materials may not cause cancer;<br />

however, if they are acted upon by<br />

certain microbial enzymes (betaglycosidase;<br />

beta-glucuronidase;<br />

steroid 7 alpha-dehydroxylase;<br />

nitroreductase and nitrate reductase;<br />

azoreductase; and tryptophanase) in<br />

the G.I. tract, it will be converted to<br />

a carcinogen. Probiotics, by their<br />

innate nature, suppress the growth of<br />

these undesirable enzyme-producing<br />

non-Probiotic bacteria, and thus<br />

reduce the chance of converting<br />

procarcinogens to carcinogens.<br />

If you analyze the entire<br />

mechanism, cancer starts with one<br />

cell through mutation. If mutagens<br />

are reduced or eliminated in the<br />

body, cancer can be controlled.<br />

Mutagens can be reduced if proper<br />

Probiotics are administered and<br />

made to colonize in the<br />

gastrointestinal tract. <strong>In</strong> our opinion,<br />

a proper diet and Probiotic therapy is<br />

the wave of the future to eliminate<br />

mutagenesis, which is the starting<br />

point of cancer.<br />

<strong>In</strong> conclusion:<br />

Since the efficacy of Probiotic<br />

therapy is linked to the proper<br />

Probiotic organisms and also their<br />

physiological condition at the time of<br />

oral administration, the following<br />

selection criteria should be followed<br />

by the physician:<br />

1. They must be of human origin.<br />

2. They must have high acid and<br />

bile stability.<br />

3. They must have adhesion<br />

properties to stick and colonize<br />

on the intestinal mucosa.<br />

4. They must be safe and clinically<br />

proven.<br />

5. They must be clinically<br />

validated.<br />

6. They must be produced or<br />

manufactured by taking into<br />

account the strain stability<br />

(plasmid retention), phage<br />

resistance and freeze drying<br />

survival.

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