Clinical Approach to Acid-base Disorders - University at Buffalo
Clinical Approach to Acid-base Disorders - University at Buffalo
Clinical Approach to Acid-base Disorders - University at Buffalo
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Compensa<strong>to</strong>ry Changes<br />
• These changes tend <strong>to</strong> correct the pH but do not<br />
completely normalize it.<br />
• An alter<strong>at</strong>ion in one component of the P a CO 2 /<br />
[HCO 3 ] - ) r<strong>at</strong>io changes the other component in the<br />
same direction i <strong>to</strong> limit i changes in [H + ]<br />
concentr<strong>at</strong>ion (and thus the pH).<br />
• Ventila<strong>to</strong>ry t response of the lungs <strong>to</strong> alter P a CO 2 is<br />
prompt but the kidney may take many hours <strong>to</strong><br />
compens<strong>at</strong>e.