Clinical Approach to Acid-base Disorders - University at Buffalo

Expected Compensatory
Responses
• Metabolic Acidosis: P a CO 2 =1.5 [HCO 3 ] - +8±2
• Metabolic alkalosis:ΔP aCO 2 =0.7× Δ[HCO[ 3 3]
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• Respiratory Acidosis:
– Acute: ↑[HCO - 3 ] = 1mEq/L×Δ Δ P a CO 2 /10
– Chronic: ↑[HCO 3 ] - = 3.5 mEq/L ×Δ P a CO 2 /10
• Respiratory alkalosis:
– Acute: ↓[HCO 3 ] - = 2 mEq/L ×Δ P a CO 2 /10
– Chronic: c:↓[ ↓[HCO - 3 ] = 4 mEq/L ×Δ P a aCO 2 /10