Clinical Approach to Acid-base Disorders - University at Buffalo

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Mixed Disturbance (contd) • Normal pH. – Low P a CO 2 indicates mixed respiratory alkalosis-metabolic acidosis. – High P aCO 2 indicates mixed respiratory acidosis-metabolic alkalosis. – Normal P aCO 2 indicates metabolic acidosis co- existing with metabolic alkalosis. Anion gap will be elevated.
Expected Compensatory Responses • Metabolic Acidosis: P a CO 2 =1.5 [HCO 3 ] - +8±2 • Metabolic alkalosis:ΔP aCO 2 =0.7× Δ[HCO[ 3 3] - • Respiratory Acidosis: – Acute: ↑[HCO - 3 ] = 1mEq/L×Δ Δ P a CO 2 /10 – Chronic: ↑[HCO 3 ] - = 3.5 mEq/L ×Δ P a CO 2 /10 • Respiratory alkalosis: – Acute: ↓[HCO 3 ] - = 2 mEq/L ×Δ P a CO 2 /10 – Chronic: c:↓[ ↓[HCO - 3 ] = 4 mEq/L ×Δ P a aCO 2 /10
Page 1 and 2: Clinical Approach to Acid-base Diso
Page 3 and 4: Acid-Base Disorders • Metabolic D
Page 5 and 6: Maintenance of Acid-Base Balance
Page 7 and 8: Rule #1: Check for Internal Consist
Page 9 and 10: Rule #2: Examine the pH • A reduc
Page 11 and 12: Rule #4:Calculate the anion gap •
Page 13 and 14: Mixed Disturbance • Acidosis •
Page 15: Mixed Disturbance (contd) • Alkal
Page 19 and 20: Metabolic Acidosis 2. High AG acido
Page 21 and 22: Metabolic Alkalosis 1. Chloride sen
Page 23: Respiratory Alkalosis 1.Problem cau

Clinical Approach to Acid-base Disorders - University at Buffalo

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