Understanding Anesthesiology - The Global Regional Anesthesia ...

spasm, intestinal spasm, increased bladder tone and pupilary
constriction. These effects are minimized by administering
an anticholinergic (atropine or glycopyrrolate)
along with the anticholinesterase.
Table 16 Dose, onset, duration, elimination of anticholinesterases
EDROPHONIUM NEOSTIGMINE PYRIDOSTIGMINE
The reader is referred to Chapter 6 for a more complete
discussion of the pharmacology of the anticholinesterase
agents as well as the anticholinergics that must accompany
their administration.
Contraindications
Anticholinesterases are contraindicated in patients with
gastrointestinal obstruction. The should be used with caution
in patients with bradycardia, asthma, seizure disorders
and Parkinson’s disease. An overdose can cause a
cholinergic crisis.
DOSE
(MG/KG)
ONSET
(MIN)
DURATION
(MIN)
RENAL
EXCRETION
0.5 - 1.0 0.025 - 0.075 0.1 - 0.3
rapid (1) intermediate (5) delayed (10)
40 - 65 55 - 75 80 - 130
70% 50% 75%
75